6-Hydroxycoumarin Chemical Properties

Melting point:

249-253 °C (lit.)

Boiling point:

248.82°C (rough estimate)

Density 

1.2500

refractive index 

1.5380 (estimate)

storage temp. 

Sealed in dry,Room Temperature

pka

8.92±0.20(Predicted)

λmax

349nm(EtOH)(lit.)

LogP

0.650 (est)

CAS DataBase Reference

6093-68-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29322010

MSDS

• Language:English Provider:SigmaAldrich

6-Hydroxycoumarin Usage And Synthesis

Description

6-Hydroxycoumarin is a coumarin which has anti-inflammatory, anti-pyretic, anti-oxidant, vasodilator, anti-amoebic, anti-bacterial, anti-fungal, bacteriostatic and antitumor activity.

Occurrence

6-Hydroxycoumarin is a natural product found in Grevillea robusta and Amburana cearensis with data available.

Uses

6-Hydroxycoumarin (cas# 6093-68-1) is a compound useful in organic synthesis.

Preparation

(1) synthesis of 6-aminocoumarins：In polar solvent, using 6- nitroscumarin as raw material, using hydrazine hydrate as hydrogen Source, is reducing catalyst using ferric chloride (FeCl36H2O), at ambient pressure reduces 6-nitroscumarin, prepare 6- aminocoumarins；
(2) synthesis of 6-Hydroxycoumarins：In sulfuric acid solution, one-step method is by 6-aminocoumarins after diazo-reaction Direct hydrolysis, prepares 6-Hydroxycoumarins in high yield.
The preparation method of 6 Hydroxycoumarins

6-Hydroxycoumarin(6093-68-1)Related Product Information

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