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7,8-DIHYDROXY-6-METHOXYCOUMARIN

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7,8-DIHYDROXY-6-METHOXYCOUMARIN Basic information

Product Name:
7,8-DIHYDROXY-6-METHOXYCOUMARIN
Synonyms:
  • Fraxetin (6-OMe, 7,8-OH)
  • 7,8-Dihydroxy-6-MethoxycouMarin 98%
  • 2H-1-Benzopyran-2-one, 7,8-dihydroxy-6-methoxy-
  • 7,8-Dihydroxy-6-methoxy-2H-chromen-2-one
  • 7,8-DIHYDROXY-6-METHOXYCOUMARIN
  • Fratexin
  • FRAXETIN
  • 7,8-dihydroxy-6-methoxy-2-benzopyrone
CAS:
574-84-5
MF:
C10H8O5
MW:
208.17
EINECS:
209-376-2
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Inhibitors
  • Coumarins
Mol File:
574-84-5.mol
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7,8-DIHYDROXY-6-METHOXYCOUMARIN Chemical Properties

Melting point:
230-231 °C (lit.)
Boiling point:
307.35°C (rough estimate)
Density 
1.3844 (rough estimate)
refractive index 
1.4717 (estimate)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO : 250 mg/mL (1200.94 mM; Need ultrasonic)
pka
7.22±0.20(Predicted)
form 
Solid
color 
White
Merck 
13,4288
Stability:
Hygroscopic
InChIKey
HAVWRBANWNTOJX-UHFFFAOYSA-N
LogP
0.590 (est)
CAS DataBase Reference
574-84-5(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29322090
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7,8-DIHYDROXY-6-METHOXYCOUMARIN Usage And Synthesis

Uses

Fraxetin is a coumarin compound with anti-oxidant and anti-inflammatory activity. Also acts as a protective agent against hyperuricemia and renal dysfunction.

Definition

ChEBI: Fraxetin is a hydroxycoumarin that is 6-methoxycoumarin in which the hydrogens at positions 7 and 8 have been replaced by hydroxy groups. It has a role as an Arabidopsis thaliana metabolite, an antimicrobial agent, an apoptosis inhibitor, an apoptosis inducer, an antioxidant, an anti-inflammatory agent, a hepatoprotective agent, an antibacterial agent and a hypoglycemic agent. It is a hydroxycoumarin and an aromatic ether.

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