7,8-DIHYDROXY-6-METHOXYCOUMARIN Chemical Properties

Melting point:

230-231 °C (lit.)

Boiling point:

307.35°C (rough estimate)

Density 

1.3844 (rough estimate)

refractive index 

1.4717 (estimate)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

DMSO : 250 mg/mL (1200.94 mM; Need ultrasonic)

pka

7.22±0.20(Predicted)

color 

White

Merck 

13,4288

Stability:

Hygroscopic

InChIKey

HAVWRBANWNTOJX-UHFFFAOYSA-N

LogP

0.590 (est)

CAS DataBase Reference

574-84-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29322090

7,8-DIHYDROXY-6-METHOXYCOUMARIN Usage And Synthesis

Uses

Fraxetin is a coumarin compound with anti-oxidant and anti-inflammatory activity. Also acts as a protective agent against hyperuricemia and renal dysfunction.

Definition

ChEBI: Fraxetin is a hydroxycoumarin that is 6-methoxycoumarin in which the hydrogens at positions 7 and 8 have been replaced by hydroxy groups. It has a role as an Arabidopsis thaliana metabolite, an antimicrobial agent, an apoptosis inhibitor, an apoptosis inducer, an antioxidant, an anti-inflammatory agent, a hepatoprotective agent, an antibacterial agent and a hypoglycemic agent. It is a hydroxycoumarin and an aromatic ether.

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