3-Amino-6-morpholinopyridine Chemical Properties

Melting point:

126-128°C

Boiling point:

414.4±45.0 °C(Predicted)

Density 

1.208±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

6.48±0.10(Predicted)

Appearance

Brown to black Solid

CAS DataBase Reference

52023-68-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-22

Safety Statements 

22-36/37/39-36/37

RIDADR 

2811

HazardClass 

IRRITANT

HS Code 

2934999090

MSDS

• Language:English Provider:ALFA

3-Amino-6-morpholinopyridine Usage And Synthesis

Uses

5-Amino-2-(4-morpholinyl)pyridine is used as pharmaceutical intermediate.

Synthesis

General procedure for the synthesis of 3-amino-6-morpholinopyridine from 4-(5-nitropyridin-2-yl)morpholine: a mixture of 1.65 g (7.8 mmol) of 4-(5-nitro-2-pyridinyl)morpholine, 160 mg of 5% Pt/C catalyst, and 20 mL of ethanol was placed in a reactor. The reaction was carried out under 50 psi hydrogen atmosphere for 5 hours. Upon completion of the reaction, the mixture was filtered through a pad of diatomaceous earth to remove the catalyst, followed by evaporation of the solvent under reduced pressure to afford 1.4 g (100% yield) of 6-(4-morpholino)-3-pyridinamine, the product being a purple solid. Its 1H NMR (400 MHz, DMSO-d6) data were as follows: δ 7.60 (d, J=2.9 Hz, 1H), 6.92 (dd, J=8.8 and 2.9 Hz, 1H), 6.62 (d, J=8.8 Hz, 1H), 4.59 (brs, 2H), 3.65-3.72 (m, 4H), 3.17 (dt, J= 4.9 and 2.4 Hz, 4H).

References

[1] Patent: WO2009/32667, 2009, A1. Location in patent: Page/Page column 148
[2] Patent: WO2009/76140, 2009, A1. Location in patent: Page/Page column 237
[3] Patent: WO2010/104899, 2010, A1. Location in patent: Page/Page column 106
[4] Patent: WO2009/154769, 2009, A1. Location in patent: Page/Page column 35
[5] Patent: WO2014/12360, 2014, A1. Location in patent: Paragraph 00355

3-Amino-6-morpholinopyridine(52023-68-4)Related Product Information

• Bis(2-ethylhexyl)amine
• 2-Aminopyridine
• Moroxydine
• ALTRENOGEST
• 3-Aminophenol
• Dibenzylamine
• Triallylamine
• Glycine
• 4-Dimethylaminopyridine
• 3-Aminopyridine
• 6-Aminocaproic acid
• Tris(hydroxymethyl)aminomethane
• 6-MORPHOLINO-3-PYRIDINYL ISOTHIOCYANATE
• 4-(5-Nitropyridin-2-yl)morpholine
• 4-{5-nitro-4-methyl-2-pyridinyl}morpholine
• 2-AMINO-4-MORPHOLINOPYRIDINE
• AMINO ACIDS
• 3-Amino-6-morpholinopyridine