ML402 Chemical Properties

Boiling point:

508.4±45.0 °C(Predicted)

Density 

1.272±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 150 mg/mL (507.13 mM)

pka

13.84±0.46(Predicted)

form 

Solid

color 

White to off-white

ML402 Usage And Synthesis

Description

ML402 is a selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator.

Uses

ML402, a thiophene-carboxamide, is a selective K2P2.1(TREK-1) and K2P10.1(TREK-2) activator. ML402 is inactive against K2P4.1(TRAAK)[1].

storage

Store at +4°C

References

[1] Lolicato M, et al. K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature. 2017 Jul 20;547(7663):364-368. DOI:10.1038/nature22988

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