Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine
Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine Basic information
- Product Name:
- Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine
- Synonyms:
-
- N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-BETA-(1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL)-L-2,3-DIAMINOPROPIONIC ACID
- N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-BETA-[1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL]-L-2,3-DIAMINOPROPIONIC ACID
- N-ALPHA-FMOC-N-BETA-1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL-L-DIAMINOPROPIONIC ACID
- 3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine
- FMOC-N-BETA-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL-L-2,3-DIAMINOPROPIONIC ACID
- FMOC-DPR(IVDDE)-OH
- FMOC-DAP(IVDDE)-OH
- FMOC-L-DAP(IVDDE)-OH
- CAS:
- 607366-20-1
- MF:
- C31H36N2O6
- MW:
- 532.63
- Product Categories:
-
- amino acid
- amino acids
- Mol File:
- 607366-20-1.mol
Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine Chemical Properties
- Boiling point:
- 733.7±60.0 °C(Predicted)
- Density
- 1.221
- storage temp.
- Store at -15°C to -25°C.
- pka
- 3.47±0.10(Predicted)
Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine Usage And Synthesis
Uses
N-alpha-Fmoc-N-beta-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-2,3-diaminopropionic Acid is used in the synthesis of phenylpyrazolo[3,4-d]pyrimidine-peptide conjugates as Src kinase inhibitors. It is also used to prepare peptidomimetic ligands for α4β1 integrin on Jurkat T-leukemia cells.
General Description
This orthogonally-protected diaminopropionic acid derivative is based on the hindered Dde variant ivDde. The side-chain ivDde group is considerably more stable to piperidine than Dde and is less prone to migrate from protected to unprotected side-chains [1]. However, migration from side-chain to the unprotected α-amino group of Dpr is unavoidable [2]. This side-reaction can, however, be minimized by the appropriate choice of coupling method for the subsequent residue, see [3].
When removing ivDde in the presence of allyl-based protecting groups, allyl alcohol should be included in the deprotection solution to prevent reduction of the allyl group [4].
The product number for this product was previously 04-12-1195.
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Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanineSupplier
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Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine(607366-20-1)Related Product Information
- Fmoc-O-trityl-L-serine
- Dimethyl sulfide
- Dimethyl ether
- D-Alanine
- p-Anisaldehyde
- p-Anisidine
- 3-(METHOXYMETHOXY)BENZALDEHYDE
- Dacthal
- Phenprobamate
- (Trifluoromethoxy)benzene
- ETHANE
- EC 2.6.1.2
- 4-Methoxyphenylacetic acid
- N,N-Dimethylformamide
- Dimethyl carbonate
- Fmoc-8-amino-3,6-dioxaoctanoic acid
- Dimethyl sulfate
- Dimethyl sulfoxide