Propargyl-PEG6-azide Chemical Properties

storage temp. 

Storage temp. 2-8°C

form 

Liquid

color 

Colorless to light yellow

Propargyl-PEG6-azide Usage And Synthesis

Uses

Propargyl-PEG6-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG6-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Biological Activity

Propargyl-PEG6-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Propargyl-PEG6-azide(1198080-03-3)Related Product Information

• Propargyl-PEG6-NHS ester
• Propargyl-PEG6-t-butyl ester