Propargyl-PEG6-azide Chemical Properties

form 

Liquid

color 

Colorless to light yellow

Propargyl-PEG6-azide Usage And Synthesis

Biological Activity

Propargyl-PEG6-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Propargyl-PEG6-azide(1198080-03-3)Related Product Information

• Propargyl-PEG6-NHS ester
• Propargyl-PEG6-t-butyl ester