Azadibenzocyclooctyne-Biotin conjugate CAS#: 1418217-95-4

Azadibenzocyclooctyne-Biotin conjugate Basic information

Product Name:

Azadibenzocyclooctyne-Biotin conjugate

Synonyms:

DBCO-Biotin
DBCO-Biotin,Azadibenzocyclooctyne-Biotin conjugate
Azadibenzocyclooctyne-Biotin conjugate
DBCO-(CH2)2-NH2-BIOTIN
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]hexahydro-2-oxo-, (3aS,4S,6aR)-
(3AS,4S,6aR)-N-[3-(11,12-Didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide

CAS:

1418217-95-4

MF:

C28H30N4O3S

MW:

502.63

Mol File:

1418217-95-4.mol

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Azadibenzocyclooctyne-Biotin conjugate Chemical Properties

Boiling point:: 905.9±65.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: -20°C, protect from light, stored under nitrogen
form: Solid
pka: 13.90±0.40(Predicted)
color: White to off-white

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Azadibenzocyclooctyne-Biotin conjugate Usage And Synthesis

Uses

DBCO-Biotin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

Alkyl-Chain

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azadibenzocyclooctyne-Biotin conjugateSupplier

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