N-Methoxy-N-methylacetamide Chemical Properties

Boiling point:

152 °C (lit.)

Density 

0.97 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.426(lit.)

Flash point:

121 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Liquid

color 

Colorless

Water Solubility 

Soluble

CAS DataBase Reference

78191-00-1(CAS DataBase Reference)

Safety Information

Risk Statements 

10

Safety Statements 

16-24/25

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

HazardClass 

3

PackingGroup 

III

HS Code 

29280000

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

N-Methoxy-N-methylacetamide Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

N-Methoxy-N-methylacetamide, is a Weinreb amide used in the synthesis of marine natural products myriaporone and usneoidone as a ketone synthon.

Preparation

N-Methoxy-N-methylacetamide can be prepared by reaction of Acetyl Chloride with commercially available N,O-Dimethylhydroxylamine hydrochloride in pyridine, followed by distillation at reduced pressure (65%).

General Description

Simple Weinreb amide used in the synthesis of marine natural products myriaporone and usneoidone as a ketone synthon.

storage

N-Methoxy-N-methylacetamide is stable but should be protected from moisture; use in a fume hood.

N-Methoxy-N-methylacetamide(78191-00-1)Related Product Information

• N-Methylacetamide
• Thioacetamide
• 2-Methoxyethanol
• Acetamide
• (Trifluoromethoxy)benzene
• Anisole
• N-Chlorosuccinimide
• N,N-Dimethylacetamide
• N,N'-Disuccinimidyl carbonate
• GMBS
• SPDP
• N-(Benzyloxycarbonyloxy)succinimide
• BOC-TRP-OSU
• N-(9-Fluorenylmethoxycarbonyloxy)succinimide
• BOLTON-HUNTER REAGENT
• N-Succinimidyl S-Acetylthioglycolate
• N-(2-Chlorobenzyloxycarbonyloxy)succinimide
• SMCC crosslinker