BIOTIN HPDP
BIOTIN HPDP Basic information
- Product Name:
- BIOTIN HPDP
- Synonyms:
-
- (3aS,4S,6aR)-Hexahydro-2-oxo-N-[6-[[1-oxo-3-(2-pyridinyldithio)propyl]amino]hexyl]-1H-thieno[3,4-d]imidazole-4-pentanamide
- N-[6-(Biotinamido)hexyl]-3'-(2'-pyridyldithio)propionamide
- N-[6-(BiotinaMido)hexyl]-3`-(2`-pyridyldithio)propionaMide(Biotin-HPDP)
- 1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-2-oxo-N-[6-[[1-oxo-3-(2-pyridinyldithio)propyl]amino]hexyl]-, (3aS,4S,6aR)-
- Biotin Impurity 31
- 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(6-(3-(pyridin-2-yldisulfanyl)propanamido)hexyl)pentanamide
- Pyridyldisulfide-biotin
- Pyridyldithiol-biotin
- CAS:
- 129179-83-5
- MF:
- C24H37N5O3S3
- MW:
- 539.78
- Product Categories:
-
- Biotin Derivatives
- MTS & Sulfhydryl Active Reagents
- BiotinylationReagents
- Mol File:
- 129179-83-5.mol
BIOTIN HPDP Chemical Properties
- Melting point:
- 160-163°C
- Boiling point:
- 876.0±65.0 °C(Predicted)
- Density
- 1.28
- storage temp.
- -20°C Freezer
- solubility
- insoluble in H2O; ≥101.4 mg/mL in DMSO; ≥8.29 mg/mL in EtOH with ultrasonic
- pka
- 13.90±0.40(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
BIOTIN HPDP Usage And Synthesis
Description
Biotin-HPDP is a sulfhydryl-reactive biotinylation reagent that forms a reversible disulfide linkage. It is used to label protein cysteines and other substrates that contain sulfhydryl groups. Biotin-HPDP is also used in the biotin switch technique to tag S-nitrosylated (SNO) proteins, following reduction of SNO groups to thiols. Compounds that are tagged with biotin interact avidly with streptavidin-coupled beads, fluorophores, enzymes, etc. The interaction of biotin-HPDP with substrates containing sulfhydryl groups is easily performed at pH 6.5 to 7.5 in buffers such as PBS. The disulfide linkage that is formed between avidin and substrate can later by cleaved by a reducing agent, like dithiothreitol.
Chemical Properties
Pale Yellow Solid
Uses
This compounds reacts specifically with thiol groups.
BIOTIN HPDPSupplier
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BIOTIN HPDP(129179-83-5)Related Product Information
- 3-[2-N-(BIOTINYL)AMINOETHYLDITHIO]PROPANOIC ACID
- BIOTINAMIDOCAPROYL HYDRAZIDE
- 1-BiotinaMido-4-[4`-(MaleiMidoMethyl)cyclohexanecarboxaMido]butane(Biotin-BMCC)
- Azide-PEG3-Desthiobiotin
- Desthiobiotin-PEG4-Alkyne
- Biotin-PEG3-Mal
- N-Biotinyl-N'-(3-maleimidopropionyl)-3,6-dioxaoctane-1,8-diamine
- DESTHIOBIOTIN N-HYDROXYSUCCINIMIDYL ESTER
- biotinylamidoethylacetamide
- SULPHOSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE
- (+)-BIOTIN-EPSILON-AMINOCAPROIC ACID
- Succinimidyl 6-(biotinamido)hexanoate
- D-DESTHIOBIOTIN
- BIOTIN-4-FLUORESCEIN
- UV-Tracer Biotin NHS Ester
- N-(3-Azidopropyl)biotinaMide
- 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-N-[2-(4-hydroxyphenyl)ethyl]-2-oxo-, (3aS,4S,6aR)-
- 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-2-oxo-N-2-propynyl-, (3aS,4S,6aR)-