ATRACTYLINE(DISCONTINUED)(SH) CAS#: 6989-21-5

ATRACTYLINE(DISCONTINUED)(SH) Basic information

Product Name:

ATRACTYLINE(DISCONTINUED)(SH)

Synonyms:

Atractyline
ATRACTYLINE(DISCONTINUED)(SH)
(4aS)-4,4aα,5,6,7,8,8a,9-Octahydro-3,8aβ-dimethyl-5-methylenenaphtho[2,3-b]furan
(4aS,8aR)-3,8a-diMethyl-5-Methylene-4,4a,5,6,7,8,8a,9-octahydronaphtho[2,3-b]furan
Naphtho[2,3-b]furan, 4,4a,5,6,7,8,8a,9-octahydro-3,8a-diMethyl-5-Methylene-, (4aS,8aR)-
(4aS,8aR)-4,4a,5,6,7,8,8a,9-Octahydro-3,8a-dimethyl-5-methylene-naphtho[2,3-b]furan

CAS:

6989-21-5

MF:

C15H20O

MW:

216.32

Product Categories:

Heterocycles

Mol File:

6989-21-5.mol

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ATRACTYLINE(DISCONTINUED)(SH) Chemical Properties

Melting point:: 61-63℃
Boiling point:: 287.1±19.0℃ (760 Torr)
Density: 1.02±0.1 g/cm3 (20 ºC 760 Torr)
Flash point:: 121.7±8.3℃
storage temp.: 2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Soild
color: Faint red to very dark red
InChI: InChI=1S/C15H20O/c1-10-5-4-6-15(3)8-14-12(7-13(10)15)11(2)9-16-14/h9,13H,1,4-8H2,2-3H3/t13-,15+/m0/s1
InChIKey: TYPSVDGIQAOBAD-DZGCQCFKSA-N
SMILES: O1C=C(C)C2C[C@]3([H])[C@@](C)(CC1=2)CCCC3=C
LogP: 5.570

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ATRACTYLINE(DISCONTINUED)(SH) Usage And Synthesis

Chemical Properties

Yellow liquid, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Atractylodes macrocephala and Atractylodes lancea.

Uses

Atractylone (Atractylon) is a sesquiterpenoid extracted from Atractylodis Rhizoma. Atractylone (Atractylon) alleviates influenza A virus (IAV)-induced lung injury via regulating the TLR7 signaling pathway, and acts as a promising agent for IAV treatment. Atractylone (Atractylon) inhibits the degranulation of mast cell and exhibits potential for the treatment of mast cell-mediated allergic reactions[1][2].

Definition

ChEBI: Atractylone is a sesquiterpenoid.

Biological Activity

Atractylon is a main active component of Atractylodis Rhizoma th at exhibits antibacterial, antiviral, anti-inflammatory, anti-allergic, anticancer, gastroprotective and neuroprotective activities. Atractylon inhibits proliferation, induces apoptosis and blocks invasion in varies hepatic cancer cell lines. It inhibits the expression of Bcl-2 and promotes the expression of Bax.

target

IL Receptor | VEGFR | Histamine Receptor

References

[1] Cheng Y, et al. Antiviral activities of atractylon from Atractylodis Rhizoma. Mol Med Rep. 2016 Oct;14(4):3704-10. DOI:10.3892/mmr.2016.5713
[2] Han NR, et al. Inhibitory effects of atractylone on mast cell-mediated allergic reactions. Chem Biol Interact. 2016 Oct 25;258:59-68. DOI:10.1016/j.cbi.2016.08.015

ATRACTYLINE(DISCONTINUED)(SH)Supplier

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