6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER Chemical Properties

Melting point:

158-165°C

storage temp. 

2-8°C

solubility 

DMSO (Slightly, Sonicated)

form 

Solid

color 

White to Pale Yellow

Stability:

Moisture Sensitive

Safety Information

HS Code 

2928.00.5000

6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER Usage And Synthesis

Chemical Properties

White Solid

Uses

A water soluble sulfhydryl and amio reactive heterobifunctional crosslinking reagent. Spacer Arm: 9.4 Angstroms

Uses

A water soluble sulfhydryl and amio reactive heterobifunctional crosslinking reagent.Spacer Arm: 9.4 Angstroms

General Description

EMCS and its water-soluble analog Sulfo-EMCS are heterobifunctional cross-linkers that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7-9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. In aqueous solutions, hydrolytic degradation of the NHS ester is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and also lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugation experiments involving these cross-linkers are usually performed at pH 7.2-7.5, with the NHS-ester (amine-targeted) reaction being accomplished before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.

6-MALEIMIDOCAPROIC ACID SULFO-N-SUCCINIMIDYL ESTER(215312-86-0)Related Product Information

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• N-Succinimidyl 3-maleimidopropionate
• 4-MALEIMIDOBUTYRIC ACID
• 2-Maleimido acetic acid
• GMBS
• 11-Maleimidoundecanoic acid
• 3-Maleimidopropionic acid
• N-Succinimidyl maleimidoacetate
• 3-Maleimidobenzoic acid N-hydroxysuccinimide ester
• 6-Maleimidocaproic acid