2-Amino-5-chloro-3-nitropyridine Chemical Properties

Melting point:

193-197 °C (lit.)

Boiling point:

305.8±37.0 °C(Predicted)

Density 

1.596

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

soluble in Dimethylformamide

form 

powder to crystal

pka

0.17±0.49(Predicted)

color 

Light yellow to Brown to Dark green

BRN 

383850

CAS DataBase Reference

5409-39-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29333999

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Amino-5-chloro-3-nitropyridine Usage And Synthesis

Chemical Properties

yellow crystalline powder

Uses

2-Amino-5-chloro-3-nitropyridine, a versatile building block, is widely used in food, health care products, cosmetics and other fields.

Synthesis

General procedure for the synthesis of 2-amino-3-nitro-5-chloropyridine from 2-amino-5-chloropyridine: 2-amino-5-chloropyridine (2.57 g, 20.0 mmol) was mixed with sulphuric acid (6.30 ml) at 25 °C, and nitric acid (0.860 ml, 21.1 mmol) was added slowly and dropwise over a period of 15 min. The reaction system was then warmed to 55°C with continuous stirring. After completion of the reaction, it was cooled to room temperature and the reaction mixture was slowly poured into ice water (60 g) and neutralized by adjusting the pH to 11 with aqueous sodium hydroxide solution. The precipitated solid product was collected by filtration, washed with deionized water and finally dried under reduced pressure at 50 °C to give 5-chloro-3-nitropyridin-2-amine (2.31 g, 67% yield, yellow solid).

References

[1] Synthetic Communications, 2012, vol. 42, # 19, p. 2791 - 2796
[2] Patent: WO2008/8398, 2008, A2. Location in patent: Page/Page column 369
[3] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 8, p. 2061 - 2071
[4] New Journal of Chemistry, 2015, vol. 39, # 5, p. 3936 - 3947
[5] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 6, p. 669 - 674

2-Amino-5-chloro-3-nitropyridine(5409-39-2)Related Product Information

• 3-Aminophenol
• 2-Amino-5-chloropyridine
• Clopidol
• 4-Dimethylaminopyridine
• 4-Chloro-3-nitropyridine
• ALTRENOGEST
• 6-Aminocaproic acid
• 3-Aminopyridine
• 1-Chloro-3-nitrobenzene
• 2-Amino-5-nitropyridine
• 2-Amino-3-nitropyridine
• Glycine
• 3-Nitropyridine
• 2-Chloro-3-nitropyridine
• 2-Aminopyridine
• Tris(hydroxymethyl)aminomethane
• Difluorochloromethane
• NITROGEN DIOXIDE