2,4-Dihydroxy-3-nitropyridine Chemical Properties

Melting point:

265°C (dec.)

Boiling point:

305.6±42.0 °C(Predicted)

Density 

1.65±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

pka

4.50±1.00(Predicted)

color 

Light yellow to Yellow to Green

BRN 

149558

InChI

InChI=1S/C5H4N2O4/c8-3-1-2-6-5(9)4(3)7(10)11/h1-2H,(H2,6,8,9)

InChIKey

BKYGVGWYPFVKTK-UHFFFAOYSA-N

SMILES

C1(=O)NC=CC(O)=C1[N+]([O-])=O

CAS DataBase Reference

89282-12-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37

RIDADR 

3335

HS Code 

29333990

MSDS

• Language:English Provider:4-Hydroxy-3-nitro-2-pyridone
• Language:English Provider:ALFA

2,4-Dihydroxy-3-nitropyridine Usage And Synthesis

Uses

2,4-Dihydroxy-3-nitropyridine can be used as a material additive, pharmaceutical chemical, and organic synthesis intermediate. During synthetic transformation, the hydroxyl groups in the structure can be easily converted into halogen atoms due to the influence of the pyridine ring and nitro group. It should be noted that by changing the reaction conditions, one of the two hydroxyl groups can be selectively halogenated, or both can be converted simultaneously. Furthermore, under acidic conditions, a bromine atom can be introduced at the 5-position of the pyridine using liquid bromine.

Chemical Properties

Yellow powder

Reactions

2,4-Dihydroxy-3-nitropyridine could be quickly transformed into 5-bromo-2,4-dihydroxy-3-nitropyridine by the action of a solution of bromine. 3.5 g of 2,4-Dihydroxy-3-nitropyridine were heated with a mixture of 1.15 ml of bromine and 30 ml of acetic acid at 70℃ for 15 minutes. When the reaction mixture was cooled with ice, 3.7 g of 5-bromo-2,4-dihydroxy-3-nitropyridine separated out[1]. Yield: 70 %

Synthesis

Step 59a. Synthesis of 2,4-dihydroxy-3-nitropyridine (compound 0108): fuming nitric acid (90 mL) was slowly added to a stirring solution of 2,4-dihydroxypyridine (0601) (100 g, 0.9 mol) dissolved in ethyl acetate (300 mL) at 0 °C. After 45 minutes of reaction, the reaction solution was carefully poured into crushed ice and the mixture was cooled in a refrigerator. The resulting precipitate was collected by filtration, washed with cold water and dried to give 4-hydroxy-3-nitropyridin-2(1H)-one (0108) (135 g, 96% yield) as a light yellow solid.LCMS: 157 [M + 1]+; 1H NMR (DMSO-d6) δ 6.05 (d, 1H, J = 7.2 Hz), 7.47 (d, 1H, J = 7.2 Hz), 11.91 (s, 1H), 12.47 (s, 1H).

References

[1] Kolder, C. R. , and H. J. D. Hertog . Migration of halogen atoms in halogeno-derivatives of 2,4-dihydroxypyridine (II). Recueil des Travaux Chimiques des Pays-Bas 72.10(2010):853-858.

2,4-Dihydroxy-3-nitropyridine(89282-12-2)Related Product Information

• 3-Nitropyridine
• DINITROTOLUENE
• 2-Hydroxypyridine
• 1,3-Dihydroxyacetone
• Triclosan
• 3-Nitro-2-pyridinol
• Solvent Red 43
• 4-Hydroxy-3-nitropyridine
• 3,4-Difluoronitrobenzene
• CHLOROPHOSPHONAZO III
• 2,6-Lutidine
• 2,4-Dihydroxypyridine
• Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
• 2,4-Dinitrofluorobenzene
• 1,3-Dinitrobenzene
• 2,4-DIHYDROXY-5-NITROPYRIDINE
• 4-Hydroxy-3-nitropyridine
• NITROGEN DIOXIDE