ASIALOGANGLIOSIDE-GM2
ASIALOGANGLIOSIDE-GM2 Basic information
- Product Name:
- ASIALOGANGLIOSIDE-GM2
- Synonyms:
-
- ganglio-n-triaosylceramide
- ASIALOGANGLIOSIDE GM2, FROM BOVINE BRAIN
- GA2 Ganglioside, Gangliotriosyl ceramide
- gangliosides (Gls)
- CERAMIDE TRIHEXOSIDE
- GG3
- GANGLIOTRIOSYL CERAMIDE
- GA2 GANGLIOSIDE
- CAS:
- 35960-33-9
- MF:
- C56H104N2O18
- MW:
- 1093.42756
- Mol File:
- 35960-33-9.mol
ASIALOGANGLIOSIDE-GM2 Chemical Properties
- storage temp.
- −20°C
- solubility
- Chloroform:Methanol:Water (2:1:0.1): Soluble
- form
- lyophilized powder
MSDS
- Language:English Provider:SigmaAldrich
ASIALOGANGLIOSIDE-GM2 Usage And Synthesis
Description
Ganglioside GM2 asialo (asialo- GM2) is a glycosphingolipid containing three monosaccharide residues and a fatty acid of variable chain length but lacking the sialic acid residue present on ganglioside M2. Asialo-GM2 levels are low-to-undetectable in normal human brain, but it accumulates in the brain of patients with Tay-Sachs and Sandhoff disease, which are neurodegenerative disorders characterized by deficiency of lysosomal β-hexosaminidase A and B, respectively. It also binds to various bacteria, including Pseudomonas isolates derived from cystic fibrosis patients. Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable lengths. [Matreya, LLC. Catalog No. 1512]
Uses
Ganglioside GM2, Asialo is a semisynthetic ganglioside.
General Description
Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.
Biochem/physiol Actions
Degraded form of Asialoganglioside-GM1 ganglioside.
ASIALOGANGLIOSIDE-GM2 Preparation Products And Raw materials
Raw materials
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