VU 0364770 Chemical Properties

Melting point:

81-83 °C

Boiling point:

293.6±20.0 °C(Predicted)

Density 

1.341±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 5 mg/ml

form 

Powder

pka

11.24±0.70(Predicted)

color 

Light yellow to yellow

VU 0364770 Usage And Synthesis

Uses

N-(3-Chlorophenyl)-2-pyridinecarboxamide shows positive allosteric modulation at the mGlu4 receptors in combination with other antagonists resulting in treatment for the neurodegenerative Parkinson’s disease (1).

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