2-Fluorobenzylamine Chemical Properties

Melting point:

245-246 °C(Solv: N,N-dimethylformamide (68-12-2))

Boiling point:

73-75 °C13 mm Hg(lit.)

Density 

1.095 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.517(lit.)

Flash point:

153 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

8?+-.0.10(Predicted)

form 

Liquid

Specific Gravity

1.095

color 

Clear colorless to yellow

Sensitive 

Air Sensitive

BRN 

508109

CAS DataBase Reference

89-99-6(CAS DataBase Reference)

NIST Chemistry Reference

Benzenemethanamine, 2-fluoro-(89-99-6)

EPA Substance Registry System

Benzenemethanamine, 2-fluoro- (89-99-6)

Safety Information

Hazard Codes 

C,Xi,T

Risk Statements 

34-20/21/22

Safety Statements 

26-27-36/37/39-45

RIDADR 

UN 2735 8/PG 2

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29214990

MSDS

• Language:English Provider:2-Fluorobenzylamine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Fluorobenzylamine Usage And Synthesis

Chemical Properties

clear colorless to yellow liquid

Uses

2-Fluorobenzylamine was used in synthesis of 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine, having anticonvulsant activity. It was also used in synthesis and study of structure-activity relationship of a series of substituted spirohydantoins.

Synthesis

General procedure for the synthesis of 2-fluorobenzylamine from 2-fluorobenzonitrile: the standard method for the reduction of nitrile by KBH4 and CuCl2 was used. The procedure was as follows: 2-fluorobenzonitrile (0.15 g, 1 mmol), KBH4 (0.17 g, 3 mmol), CuCl2 (0.03 g, 0.25 mmol), and 80% isopropanol solution (1.6 mL of isopropanol and 0.4 mL of water) were added to a 10 mL round-bottom flask. The reaction was carried out at 60 °C and the progress of the reaction was monitored by TLC (unfolding agent ratio of DCM:MeOH 10:1) to confirm that the reaction was completed within 8 hours. Upon completion of the reaction, the mixture was cooled to 25 °C and the solvent was subsequently removed under reduced pressure. Ethyl acetate (5 mL) was added to the residue and washed sequentially with water (1 mL) and saturated saline (1 mL). The organic layer was dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give the crude product 2-fluorobenzylamine.

References

[1] Journal of the American Chemical Society, 2015, vol. 137, # 28, p. 8888 - 8891
[2] Synlett, 2001, # 10, p. 1623 - 1625
[3] Small, 2018, vol. 14, # 37,
[4] ChemCatChem, 2017, vol. 9, # 4, p. 559 - 563
[5] Asian Journal of Chemistry, 2015, vol. 27, # 10, p. 3564 - 3566

2-Fluorobenzylamine(89-99-6)Related Product Information

• 2-Fluorobenzophenone
• 2-Bromofluorobenzene
• alpha-Chloro-o-fluorotoluene
• 2-Fluorobenzoic acid
• 2-Fluorobenzenesulfonyl chloride
• 2-Fluoroaniline
• 2'-Fluoroacetanilide
• 2-(Trifluoromethoxy)fluorobenzene
• 2-Fluorobenzyl cyanide
• 2-Fluorotoluene
• DL-ALPHA-METHYLBENZYLAMINE
• Benzylamine
• Trimethoprim
• 4-(Aminomethyl)benzoic acid
• Phenoxybenzamine hydrochloride
• 4-FLUOROBENZYLAMINE 98+%,4-Fluorobenzylamine 98%,4-Fluorobenzylamine ,99%
• 2-Chloro-6-fluorobenzylamine 98%,2-Chloro-6-fluorobenzylamine98%
• 2-Fluorobenzamide