2'-Fluoroacetanilide Chemical Properties

Melting point:

77-79 °C(lit.)

Boiling point:

140-142 °C14 mm Hg(lit.)

Density 

1.1655 (estimate)

Flash point:

140-142°C/14mm

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

pka

14.04±0.70(Predicted)

form 

Fine Crystalline Powder

color 

White

BRN 

2717443

CAS DataBase Reference

399-31-5(CAS DataBase Reference)

NIST Chemistry Reference

Acetamide, N-(2-fluorophenyl)-(399-31-5)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29242998

MSDS

• Language:English Provider:2'-Fluoroacetanilide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2'-Fluoroacetanilide Usage And Synthesis

Chemical Properties

white fine crystalline powder

Uses

2''-Fluoroacetanilide

Synthesis

Step 1: Synthesis of N-(2-fluorophenyl)acetamide To a solution of 2-fluoroaniline (5.0 g, 45.05 mmol) in dichloromethane (DCM, 225 mL) was sequentially added acetic anhydride (4.09 mL, 45.05 mmol) and triethylamine (7.55 mL, 54.05 mmol). The reaction mixture was stirred at room temperature for 6 hours. After completion of the reaction, the mixture was concentrated, diluted with ethyl acetate and washed with 1N hydrochloric acid (2 x 50 mL). The organic phase was dried with anhydrous sodium sulfate (Na2SO4) and concentrated to give N-(2-fluorophenyl)acetamide (6.20 g, 90% yield) as a white solid.LCMS analysis showed the molecular ion peak of the target product to be 153.99 (M + H)+.

References

[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 11, p. 2187 - 2196
[2] Patent: US2008/139558, 2008, A1. Location in patent: Page/Page column 80
[3] Journal of the Chemical Society - Perkin Transactions 1, 1996, # 7, p. 669 - 673
[4] Patent: US2012/238543, 2012, A1. Location in patent: Page/Page column 13
[5] Patent: US2012/270854, 2012, A1. Location in patent: Page/Page column 20

2'-Fluoroacetanilide(399-31-5)Related Product Information

• N-ACETYL-L-TYROSINE ETHYL ESTER
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• 2-BENZOYLACETANILIDE
• p-Acetotoluidide
• 3-Fluoroaniline
• 4-(Trifluoromethoxy)aniline
• 2-Fluoroaniline
• Acetamide
• 4'-Aminoacetanilide
• 4'-Nitroacetanilide
• Acetylacetone
• 4-Fluoroaniline
• Acetylferrocene
• 2-Fluorobenzophenone
• 2-Bromofluorobenzene
• alpha-Chloro-o-fluorotoluene
• 2-Fluorobenzoic acid
• 2-Fluorobenzenesulfonyl chloride