N6022
N6022 Basic information
- Product Name:
- N6022
- Synonyms:
-
- N6022
- 1-[4-(Aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid
- 1-[4-(Aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid N 6022
- N6022, >=98%
- 3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-imidazol-1-ylphenyl)pyrrol-2-yl]propanoic acid
- N 6022; N-6022
- CS-1460
- 1H-Pyrrole-2-propanoic acid, 1-[4-(aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-
- CAS:
- 1208315-24-5
- MF:
- C24H22N4O3
- MW:
- 414.46
- Product Categories:
-
- Inhibitors
- Mol File:
- 1208315-24-5.mol
N6022 Chemical Properties
- Boiling point:
- 662.7±55.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- -20° C
- solubility
- Soluble in DMSO (up to at least 25 mg/ml).
- form
- solid
- pka
- 4.63±0.10(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
N6022 Usage And Synthesis
Description
N6022 (1208315-24-5) is a potent and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) – IC50?= 20 nM1, 8 nM2. It demonstrated significant efficacy in mouse models of ovalbumin-induced asthma, chronic obstructive pulmonary disease, and irritable bowel syndrome. N6022 was able to attenuate experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis)?via?selective inhibition of pro-inflammatory CD4+?cells (TH1/TH17) while upregulating anti-inflammatory subsets of CD4+?cells (TH2/Treg) without causing lymphopenia.3
Uses
N6022 is a tight-binding, specific, and fully reversible inhibitor of S-nitrosoglutathione reductase.
in vivo
N6022 (50 mg/kg) treated rats showed a slight increase in the incidence of granulomas. N6022 concentrations in solution were as high as 5 mg/mL in serum[1].
References
[1] XICHENG SUN*. Discovery of S-Nitrosoglutathione Reductase Inhibitors: Potential Agents for the Treatment of Asthma and Other Inflammatory Diseases[J]. ACS Medicinal Chemistry Letters, 2011, 2 5: 402-406. DOI:10.1021/ml200045s
[2] LOUIS S. GREEN. Mechanism of Inhibition for N6022, a First-in-Class Drug Targeting S-Nitrosoglutathione Reductase[J]. Biochemistry Biochemistry, 2012, 51 10: 2157-2168. DOI:10.1021/bi201785u
[3] NISHANT SAXENA . S-nitrosoglutathione reductase (GSNOR) inhibitor as an immune modulator in experimental autoimmune encephalomyelitis[J]. Free Radical Biology and Medicine, 2018, 121: Pages 57-68. DOI:10.1016/j.freeradbiomed.2018.04.558
N6022Supplier
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