N6022
- Product Name
- N6022
- CAS No.
- 1208315-24-5
- Chemical Name
- N6022
- Synonyms
- N6022;CS-1460;N6022, >=98%;N6022 ，S7589;N 6022; N-6022;N6022, 10 mM in DMSO;N6022,Inhibitor,inhibit,N 6022,S-nitrosoglutathione reductase,N-6022,GSNOR;3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-imidazol-1-ylphenyl)pyrrol-2-yl]propanoic acid;3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid;1-[4-(Aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid
- CBNumber
- CB92628180
- Molecular Formula
- C24H22N4O3
- Formula Weight
- 414.46
- MOL File
- 1208315-24-5.mol
N6022 Property
- Boiling point:
- 662.7±55.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- -20° C
- solubility
- Soluble in DMSO (up to at least 25 mg/ml).
- form
- solid
- pka
- 4.63±0.10(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 21269
- Product name
- N6022
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $30
- Updated
- 2024/03/01
- Product number
- 21269
- Product name
- N6022
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $67
- Updated
- 2024/03/01
- Product number
- 21269
- Product name
- N6022
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 21269
- Product name
- N6022
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $220
- Updated
- 2024/03/01
- Product number
- N926020
- Product name
- N6022
- Packaging
- 1mg
- Price
- $50
- Updated
- 2021/12/16
N6022 Chemical Properties,Usage,Production
Description
N6022 (1208315-24-5) is a potent and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) – IC50?= 20 nM1, 8 nM2. It demonstrated significant efficacy in mouse models of ovalbumin-induced asthma, chronic obstructive pulmonary disease, and irritable bowel syndrome. N6022 was able to attenuate experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis)?via?selective inhibition of pro-inflammatory CD4+?cells (TH1/TH17) while upregulating anti-inflammatory subsets of CD4+?cells (TH2/Treg) without causing lymphopenia.3
Uses
N6022 is a tight-binding, specific, and fully reversible inhibitor of S-nitrosoglutathione reductase.
in vivo
N6022 (50 mg/kg) treated rats showed a slight increase in the incidence of granulomas. N6022 concentrations in solution were as high as 5 mg/mL in serum[1].
References
[1] XICHENG SUN*. Discovery of S-Nitrosoglutathione Reductase Inhibitors: Potential Agents for the Treatment of Asthma and Other Inflammatory Diseases[J]. ACS Medicinal Chemistry Letters, 2011, 2 5: 402-406. DOI:10.1021/ml200045s
[2] LOUIS S. GREEN. Mechanism of Inhibition for N6022, a First-in-Class Drug Targeting S-Nitrosoglutathione Reductase[J]. Biochemistry Biochemistry, 2012, 51 10: 2157-2168. DOI:10.1021/bi201785u
[3] NISHANT SAXENA . S-nitrosoglutathione reductase (GSNOR) inhibitor as an immune modulator in experimental autoimmune encephalomyelitis[J]. Free Radical Biology and Medicine, 2018, 121: Pages 57-68. DOI:10.1016/j.freeradbiomed.2018.04.558
N6022 Preparation Products And Raw materials
Raw materials
Preparation Products
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