N6022

Product Name: N6022
CAS No.: 1208315-24-5
Chemical Name: N6022
Synonyms: N6022;CS-1460;N6022, >=98%;N 6022; N-6022;N6022,Inhibitor,inhibit,N 6022,S-nitrosoglutathione reductase,N-6022,GSNOR;3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-imidazol-1-ylphenyl)pyrrol-2-yl]propanoic acid;3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid;1-[4-(Aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid;1H-Pyrrole-2-propanoic acid, 1-[4-(aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-;1-[4-(Aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid N 6022
CBNumber: CB92628180
Molecular Formula: C24H22N4O3
Formula Weight: 414.46
MOL File: 1208315-24-5.mol

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N6022 Property

Boiling point:: 662.7±55.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: -20° C
solubility: Soluble in DMSO (up to at least 25 mg/ml).
form: solid
pka: 4.63±0.10(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21269
Product name: N6022
Purity: ≥98%
Packaging: 1mg
Price: $30
Updated: 2024/03/01

Cayman Chemical

Product number: 21269
Product name: N6022
Purity: ≥98%
Packaging: 5mg
Price: $67
Updated: 2024/03/01

Cayman Chemical

Product number: 21269
Product name: N6022
Purity: ≥98%
Packaging: 10mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 21269
Product name: N6022
Purity: ≥98%
Packaging: 25mg
Price: $220
Updated: 2024/03/01

TRC

Product number: N926020
Product name: N6022
Packaging: 1mg
Price: $50
Updated: 2021/12/16

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N6022 Chemical Properties,Usage,Production

Description

N6022 (1208315-24-5) is a potent and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) – IC50?= 20 nM1, 8 nM2. It demonstrated significant efficacy in mouse models of ovalbumin-induced asthma, chronic obstructive pulmonary disease, and irritable bowel syndrome. N6022 was able to attenuate experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis)?via?selective inhibition of pro-inflammatory CD4+?cells (TH1/TH17) while upregulating anti-inflammatory subsets of CD4+?cells (TH2/Treg) without causing lymphopenia.3

Uses

N6022 is a tight-binding, specific, and fully reversible inhibitor of S-nitrosoglutathione reductase.

References

1) Sun?et al.?(2011),?Discovery of s-nitrosoglutathione reductase inhibitors: potential agents for the treatment of asthma and other inflammatory diseases; ACS Med. Chem. Lett.?2?402 2) Green?et al.?(2012),?Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase; Biochemistry?51?2157 3) Saxena?et al.?(20198),?S-Nitrosoglutathione reductase (GSNOR) inhibitor as an immune modulator in experimental autoimmune encephalomyelitis; Free Radic. Biol. Med.?121?57

N6022 Preparation Products And Raw materials

Raw materials

Preparation Products

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N6022 Suppliers

China 75 India 1 United States 12 Global 88

Shanghai Boyle Chemical Co., Ltd.

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MedChemexpress LLC

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Shanghai Taifu Pharmaceutical Technology Co. LTD

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N6022

1-[4-(Aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid

1-[4-(Aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid N 6022

N6022, >=98%

3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-imidazol-1-ylphenyl)pyrrol-2-yl]propanoic acid

N 6022; N-6022

CS-1460

1H-Pyrrole-2-propanoic acid, 1-[4-(aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-

3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid

N6022,Inhibitor,inhibit,N 6022,S-nitrosoglutathione reductase,N-6022,GSNOR

1208315-24-5

Inhibitors