VUN65671

Product Name: VUN65671
CAS No.: 2479465-67-1
Chemical Name: VUN65671
Synonyms: VUN65671;EBOV/MARV-IN-1;Ebola and Marburg Entry Inhibitor;MARV,EBOV,virus,Filovirus,inhibit,Inhibitor,VUN-65671,VUN65671,Ebola,Marburg;N-(4-(4-Methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-4-(morpholinomethyl)benzamide;Benzamide, N-[4-(4-methyl-1-piperidinyl)-3-(trifluoromethyl)phenyl]-4-(4-morpholinylmethyl)-
CBNumber: CB38078361
Molecular Formula: C25H30F3N3O2
Formula Weight: 461.52
MOL File: 2479465-67-1.mol

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VUN65671 Property

Boiling point:: 505.0±50.0 °C(Predicted)
Density: 1.242±0.06 g/cm3(Predicted)
form: Solid
pka: 12.89±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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VUN65671 Chemical Properties,Usage,Production

Uses

EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV), with broad-spectrum activity (EC50=0.31, and 0.82 μM, respectively) and low cytotoxicity (SI>100) in HeLa cells[1].

IC 50

EBOV; MARV

References

[1] Gaisina IN, et, al. Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections. J Med Chem. 2020 Jul 9;63(13):7211-7225. DOI:10.1021/acs.jmedchem.0c00463

VUN65671 Preparation Products And Raw materials

Raw materials

Preparation Products

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VUN65671 Suppliers

China 19 United States 4 Global 23

Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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TargetMol Chemicals Inc.

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Shanghai Dongyang Biotechnology Co., Ltd.

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Bide Pharmatech Ltd.

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InvivoChem

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Beijing Biocreative Technology Co., Ltd.

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Shanghai Jieshikai Biotechnology Co. , Ltd.

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2479465-67-1, VUN65671Related Search:

VU0134992(hydrochloride) VU6012962 VU0810464 VU6015929 VU0238441 N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin VU 0357121 VU6010608 VU 0364439 VU-29 VU 0357017 hydrochloride 2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide VUF 10460 VUF 10166 N6022 VU 0364770 1-(4-BROMOBENZYL)INDOLE-2,3-DIONE

VUN65671

EBOV/MARV-IN-1

Ebola and Marburg Entry Inhibitor

MARV,EBOV,virus,Filovirus,inhibit,Inhibitor,VUN-65671,VUN65671,Ebola,Marburg

N-(4-(4-Methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl)-4-(morpholinomethyl)benzamide

Benzamide, N-[4-(4-methyl-1-piperidinyl)-3-(trifluoromethyl)phenyl]-4-(4-morpholinylmethyl)-

2479465-67-1