2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide

Product Name: 2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
CAS No.: 755002-90-5
Chemical Name: 2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
Synonyms: VU0134992;VU0134992, 10 mM in DMSO;2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide;2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide;Acetamide, 2-[2-bromo-4-(1-methylethyl)phenoxy]-N-(2,2,6,6-tetramethyl-4-piperidinyl)-;natriuresis,hypertension,electrophysiology,whole-cell,selective,VU0134992,diuresis,Potassium Channel,oral,VU-0134992,patch-clamp,KcsA,Inhibitor,inhibit,Kir4.1,kaliuresis
CBNumber: CB93784942
Molecular Formula: C20H31BrN2O2
Formula Weight: 411.38
MOL File: 755002-90-5.mol

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2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide Property

solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 6877
Product name: VU0134992
Purity: ≥98%(HPLC)
Packaging: 10
Price: $175
Updated: 2021/12/16

DC Chemicals

Product number: DC23646
Product name: VU0134992
Purity: >98%
Packaging: 250mg
Price: $1200
Updated: 2021/12/16

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2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide Chemical Properties,Usage,Production

Uses

VU0134992 is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 μM. VU0134992 is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 μM) at -120 mV[1].

in vivo

VU0134992 (50-100 mg/kg; oral gavage) statistically significantly increased urinary Na⁺ as well as K⁺ excretion^[1].

Animal Model:	Male Sprague-Dawley rats (250-300 g)^[1]
Dosage:	50 and 100 mg/kg
Administration:	Oral gavage
Result:	Statistically significantly increased urinary Na+ as well as K⁺ excretion

storage

Store at -20°C

References

[1] Kharade SV, et al. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol. 2018 Aug;94(2):926-937. DOI:10.1124/mol.118.112359

2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide Suppliers

China 29 Russia 1 United States 4 Global 34

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755002-90-5, 2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamideRelated Search:

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2-[2-bromo-4-(propan-2-yl)phenoxy]-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide

VU0134992

Acetamide, 2-[2-bromo-4-(1-methylethyl)phenoxy]-N-(2,2,6,6-tetramethyl-4-piperidinyl)-

natriuresis,hypertension,electrophysiology,whole-cell,selective,VU0134992,diuresis,Potassium Channel,oral,VU-0134992,patch-clamp,KcsA,Inhibitor,inhibit,Kir4.1,kaliuresis

2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide

VU0134992, 10 mM in DMSO

755002-90-5

C20H31BrN2O2