ChemicalBook > CAS DataBase List > N6022

N6022

Product Name: N6022
CAS No.: 1208315-24-5
Chemical Name: N6022
Synonyms: N6022;CS-1460;N6022, >=98%;N6022 ，S7589;N 6022; N-6022;N6022, 10 mM in DMSO;N6022,Inhibitor,inhibit,N 6022,S-nitrosoglutathione reductase,N-6022,GSNOR;3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-imidazol-1-ylphenyl)pyrrol-2-yl]propanoic acid;3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid;1-[4-(Aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid
CBNumber: CB92628180
Molecular Formula: C24H22N4O3
Formula Weight: 414.46
MOL File: 1208315-24-5.mol

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N6022 Property

Boiling point:: 662.7±55.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: -20° C
solubility: Soluble in DMSO (up to at least 25 mg/ml).
form: solid
pka: 4.63±0.10(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21269
Product name: N6022
Purity: ≥98%
Packaging: 1mg
Price: $30
Updated: 2024/03/01

Cayman Chemical

Product number: 21269
Product name: N6022
Purity: ≥98%
Packaging: 5mg
Price: $67
Updated: 2024/03/01

Cayman Chemical

Product number: 21269
Product name: N6022
Purity: ≥98%
Packaging: 10mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 21269
Product name: N6022
Purity: ≥98%
Packaging: 25mg
Price: $220
Updated: 2024/03/01

TRC

Product number: N926020
Product name: N6022
Packaging: 1mg
Price: $50
Updated: 2021/12/16

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N6022 Chemical Properties,Usage,Production

Description

N6022 (1208315-24-5) is a potent and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) – IC50?= 20 nM1, 8 nM2. It demonstrated significant efficacy in mouse models of ovalbumin-induced asthma, chronic obstructive pulmonary disease, and irritable bowel syndrome. N6022 was able to attenuate experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis)?via?selective inhibition of pro-inflammatory CD4+?cells (TH1/TH17) while upregulating anti-inflammatory subsets of CD4+?cells (TH2/Treg) without causing lymphopenia.3

Uses

N6022 is a tight-binding, specific, and fully reversible inhibitor of S-nitrosoglutathione reductase.

in vivo

N6022 (50 mg/kg) treated rats showed a slight increase in the incidence of granulomas. N6022 concentrations in solution were as high as 5 mg/mL in serum^[1].

References

[1] XICHENG SUN*. Discovery of S-Nitrosoglutathione Reductase Inhibitors: Potential Agents for the Treatment of Asthma and Other Inflammatory Diseases[J]. ACS Medicinal Chemistry Letters, 2011, 2 5: 402-406. DOI:10.1021/ml200045s
[2] LOUIS S. GREEN. Mechanism of Inhibition for N6022, a First-in-Class Drug Targeting S-Nitrosoglutathione Reductase[J]. Biochemistry Biochemistry, 2012, 51 10: 2157-2168. DOI:10.1021/bi201785u
[3] NISHANT SAXENA . S-nitrosoglutathione reductase (GSNOR) inhibitor as an immune modulator in experimental autoimmune encephalomyelitis[J]. Free Radical Biology and Medicine, 2018, 121: Pages 57-68. DOI:10.1016/j.freeradbiomed.2018.04.558

N6022 Preparation Products And Raw materials

Raw materials

Preparation Products

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N6022 Suppliers

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N6022

1-[4-(Aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid

1-[4-(Aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid N 6022

N6022, >=98%

3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-imidazol-1-ylphenyl)pyrrol-2-yl]propanoic acid

N 6022; N-6022

CS-1460

1H-Pyrrole-2-propanoic acid, 1-[4-(aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-

3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid

N6022,Inhibitor,inhibit,N 6022,S-nitrosoglutathione reductase,N-6022,GSNOR

N6022, 10 mM in DMSO

N6022 ，S7589

1208315-24-5

Inhibitors