N6022
- Product Name
- N6022
- CAS No.
- 1208315-24-5
- Chemical Name
- N6022
- Synonyms
- N6022;CS-1460;N6022, >=98%;N 6022; N-6022;N6022,Inhibitor,inhibit,N 6022,S-nitrosoglutathione reductase,N-6022,GSNOR;3-[1-(4-carbamoyl-2-methylphenyl)-5-(4-imidazol-1-ylphenyl)pyrrol-2-yl]propanoic acid;3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid;1-[4-(Aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid;1H-Pyrrole-2-propanoic acid, 1-[4-(aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-;1-[4-(Aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid N 6022
- CBNumber
- CB92628180
- Molecular Formula
- C24H22N4O3
- Formula Weight
- 414.46
- MOL File
- 1208315-24-5.mol
N6022 Property
- Boiling point:
- 662.7±55.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- -20° C
- solubility
- Soluble in DMSO (up to at least 25 mg/ml).
- form
- solid
- pka
- 4.63±0.10(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
N-Bromosuccinimide Price
- Product number
- 21269
- Product name
- N6022
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $30
- Updated
- 2024/03/01
- Product number
- 21269
- Product name
- N6022
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $67
- Updated
- 2024/03/01
- Product number
- 21269
- Product name
- N6022
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 21269
- Product name
- N6022
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $220
- Updated
- 2024/03/01
- Product number
- N926020
- Product name
- N6022
- Packaging
- 1mg
- Price
- $50
- Updated
- 2021/12/16
N6022 Chemical Properties,Usage,Production
Description
N6022 (1208315-24-5) is a potent and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) – IC50?= 20 nM1, 8 nM2. It demonstrated significant efficacy in mouse models of ovalbumin-induced asthma, chronic obstructive pulmonary disease, and irritable bowel syndrome. N6022 was able to attenuate experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis)?via?selective inhibition of pro-inflammatory CD4+?cells (TH1/TH17) while upregulating anti-inflammatory subsets of CD4+?cells (TH2/Treg) without causing lymphopenia.3
Uses
N6022 is a tight-binding, specific, and fully reversible inhibitor of S-nitrosoglutathione reductase.
References
1) Sun?et al.?(2011),?Discovery of s-nitrosoglutathione reductase inhibitors: potential agents for the treatment of asthma and other inflammatory diseases; ACS Med. Chem. Lett.?2?402 2) Green?et al.?(2012),?Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase; Biochemistry?51?2157 3) Saxena?et al.?(20198),?S-Nitrosoglutathione reductase (GSNOR) inhibitor as an immune modulator in experimental autoimmune encephalomyelitis; Free Radic. Biol. Med.?121?57
N6022 Preparation Products And Raw materials
Raw materials
Preparation Products
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