CASPASE INHIBITOR3 Chemical Properties

Boiling point:

383.5±37.0 °C(Predicted)

Density 

1.150±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

-20°C

solubility 

Soluble in dry DMSO or DMF at approximately 20mM. Store stock solutions at -20°C.

form 

Powder

pka

10.12±0.46(Predicted)

color 

Off-white

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

CASPASE INHIBITOR3 Usage And Synthesis

Uses

N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone is used as a novel Boc-D(OMe)-FMK inhibitor synthesized using proprietary technology and irreversibly binds to activated caspases to block apoptosis. It is useful for in vitro and in vivo applications.

Uses

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites .

Biochem/physiol Actions

Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10.

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