PF-06700841 tosylate Chemical Properties

Boiling point:

637.1±65.0 °C(Predicted)

Density 

1.63±0.1 g/cm3(Predicted)

storage temp. 

room temp

solubility 

DMSO: 78 mg/mL (200.31 mM);Ethanol: 78 mg/mL (200.31 mM)

form 

powder

pka

7.28±0.10(Predicted)

color 

white to beige

Water Solubility 

Water: Insoluble

PF-06700841 tosylate Usage And Synthesis

Uses

PF-06700841 tosylate salt has been used as an inhibitor of Janus kinase1 (JAK1) to study its therapeutic effect on the adjuvant induced arthritis (AIA) rat model. It has also been used as an inhibitor of interferon-α/β receptor alpha chain (IFNAR1) signaling adaptor tyrosine kinase (2TYK2) in mice.

Biochem/physiol Actions

PF-06700841 prevents IL-23 (interleukin 23) signaling through TYK2 (Tyrosine-protein kinase 2)/JAK1 (Janus kinase 1) inhibition.

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