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HYOSCINE HYDROCHLORIDE

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HYOSCINE HYDROCHLORIDE Basic information

Product Name:
HYOSCINE HYDROCHLORIDE
Synonyms:
  • SCOPINE TROPATE HYDROCHLORIDE
  • SCOPINE TROPATE
  • (-)-SCOPOLAMINE HYDROCHLORIDE
  • SCOPOLAMINE HYDROCHLORIDE
  • HYOSCINE HYDROCHLORIDE
  • 0(sup2,4))non-7-ylester,hydrochloride,(7(s)-(1-alpha,2-beta,4-beta,5-alpha
  • 5-alpha-h-tropan-3-alpha-ol,6-beta,7-beta-epoxy-1-alpha-(-)-tropate(est
  • chlorhydratedescopolamine
CAS:
55-16-3
MF:
C17H22ClNO4
MW:
339.81
EINECS:
200-225-6
Product Categories:
  • Pyrrolidines ,Pyrroles
Mol File:
55-16-3.mol
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HYOSCINE HYDROCHLORIDE Chemical Properties

Melting point:
200°
Flash point:
77 °C
storage temp. 
-20°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
white
optical activity
[α]25/D ~ 27°, c = 1 in H2O(lit.)
Water Solubility 
H2O: 50mg/mL
BRN 
4168778
CAS DataBase Reference
55-16-3(CAS DataBase Reference)
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Safety Information

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
25-45-36/37-28
RIDADR 
UN 1544 6.1/PG 3
WGK Germany 
3
RTECS 
CY1634501
F 
3-8

MSDS

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HYOSCINE HYDROCHLORIDE Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

Uses

Antiemetic;Non-selective muscarinic antagonist

Biochem/physiol Actions

Competitive nonselective muscarinic acetylcholine antagonist. Scopolamine-induced amnesia in laboratory animals is a commonly-used model of memory deficit.

in vivo

Scopolamine induces memory impairment associated with attenuation of cholinergic neurotransmission, as well as an increases of processes connected with oxidative stress in the brain[3].

Animal Model:Naive male Swiss mice weighing 20-25[3]
Dosage:1 mg/kg
Administration:Administered intraperitoneally (i.p.); to measure the memory acquisition processes, Scopolamine was administered 20 min before the pretest; to measure the memory consolidation processes, Scopolamine was administered immediately after the pretest
Result:In scopolamine-treated group, there was a significant decrease in the index of latency (IL) value as compared with the saline-treated mice, indicating that scopolamine at the used dose impaired acquisition of memory and learning.

IC 50

5-HT3 Receptor: 2.09 μM (IC50)

HYOSCINE HYDROCHLORIDESupplier

Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Email
marketing_china@spectrumchemical.com
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Email
800078821@qq.com
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Email
tauto@tautobiotech.com
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Email
info@tsbiochem.com
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