3-Oxocyclobutanecarboxylic acid

Product Name: 3-Oxocyclobutanecarboxylic acid
CAS No.: 23761-23-1
Chemical Name: 3-Oxocyclobutanecarboxylic acid
Synonyms: 3-oxocyclobutane-1-carboxylic acid;3-OXO-CYCLOBUTANECARBOXYLIC ACID;3-oxocyclobutane-1,1-dicarboxylic acid;3-OxocycL;IFLAB-BB F2124-0041;1-Carboxy-3-oxocyclobutane;3-Oxocyclobutanecarboxylic;3-Oxocyclobutanecarboxyli...;Oxocyclobutanecarboxylic acid;3-Oxycyclobutanecarboxylic acid
CBNumber: CB0111483
Molecular Formula: C5H6O3
Formula Weight: 114.1
MOL File: 23761-23-1.mol

More

Less

3-Oxocyclobutanecarboxylic acid Property

Melting point:: 69-70℃
Boiling point:: 296°C
Density: 1.431
Flash point:: 147°C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Solid
pka: 4.35±0.20(Predicted)
color: Off-white
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C5H6O3/c6-4-1-3(2-4)5(7)8/h3H,1-2H2,(H,7,8)
InChIKey: IENOFRJPUPTEMI-UHFFFAOYSA-N
SMILES: C1(C(O)=O)CC(=O)C1
CAS DataBase Reference: 23761-23-1(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 26-37-60
TSCA: No
HS Code: 29189900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS004694
Product name: 3-Oxocyclobutanecarboxylic acid
Purity: AldrichCPR
Packaging: 100mg
Price: $70.9
Updated: 2024/03/01

TCI Chemical

Product number: O0392
Product name: 3-Oxocyclobutanecarboxylic Acid
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $16
Updated: 2024/03/01

TCI Chemical

Product number: O0392
Product name: 3-Oxocyclobutanecarboxylic Acid
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $52
Updated: 2024/03/01

Alfa Aesar

Product number: H64774
Product name: 3-Oxocyclobutanecarboxylic acid, 98%
Packaging: 5g
Price: $51.65
Updated: 2024/03/01

Alfa Aesar

Product number: H64774
Product name: 3-Oxocyclobutanecarboxylic acid, 98%
Packaging: 25g
Price: $207.65
Updated: 2024/03/01

More

Less

3-Oxocyclobutanecarboxylic acid Chemical Properties,Usage,Production

Description

3-Oxocyclobutanecarboxylic acid is an organic common intermediate compound used in pharmaceuticals, organic synthesis and organic light-emitting diode (OLED) intermediates. Abrocitinib, prepared from 3-Oxocyclobutanecarboxylic acid, is approved for the treatment of adult patients with atopic dermatitis (AD), as well as patients with refractory moderate to severe AD who have had limited or minimal response to other systemic medications.

Chemical Properties

White solid

Uses

3-Oxocyclobutanecarboxylic Acid (cas# 23761-23-1) is a compound useful in organic synthesis.

Application

3-Oxocyclobutanecarboxylic acid is a very important medicine intermediate, it is widely applied in the synthetic of tens kinds of bulk drugs, such as ACK1 antibody, the MDM2 antagonist, the JAK inhibitor, CETP inhibitor, kinase inhibitor, the PDE10 inhibitor, thrombin inhibitors and in autoimmunization chronic inflammatory diseases and antitumor drug, all being used to.

Preparation

The target product 3-oxocyclobutanecarboxylic acid is obtained by adopting acetone, bromine, and malononitrile as raw materials, adopting ethanol, DMF (dimethyl formamide), and water as solvents, adopting sodium iodide as an activating agent and tetrabutylammonium bromide (TBAB) as a phase transfer catalyst through three-step reaction.

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 3841, 1988 DOI: 10.1021/jo00251a033

3-Oxocyclobutanecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-Oxocyclobutanecarboxylic acid Suppliers

Americas 1 Canada 3 China 429 Europe 1 Germany 2 India 35 Japan 1 Switzerland 2 Ukraine 2 United Kingdom 6 United States 36 Global 518

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

Accela ChemBio Inc.

Tel: +1(858) 699-3322
Fax: +1(858) 876-1948
Email: marketing@accelachem.com
Country: United States
ProdList: 6024
Advantage: 65

AbaChemScene

Tel: 732-484-9848
Fax: 888-484-5008
Email: sales@chemscene.com
Country: United States
ProdList: 3982
Advantage: 60

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 17453
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Protheragen-ING

Tel: +16313385890
Email: info@protheragen-ing.com
Country: United States
ProdList: 3868
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Accela ChemBio Inc.

Tel: --
Fax: --
Email: info@accelachem.com
Country: United States
ProdList: 1054
Advantage: 50

AstaTech, Inc.

Tel: --
Fax: --
Email: sales@astatechinc.com
Country: United States
ProdList: 904
Advantage: 58

ARC Scientific

Tel: --
Fax: --
Email: sales@arc-scientific.com
Country: United States
ProdList: 22
Advantage: 58

Combi-Blocks, Inc.

Tel: --
Fax: --
Email: les@combi-blocks.com
Country: United States
ProdList: 2555
Advantage: 58

Redox Scientific

Tel: --
Fax: --
Email: info@redoxsci.com
Country: United States
ProdList: 2380
Advantage: 58

Exim-Indis, Inc. (part of Exim Corporation and Indis N.V.)

Tel: --
Fax: --
Email: info@exim-indis.com
Country: United States
ProdList: 440
Advantage: 58

Chemphtec Corporation

Tel: --
Fax: --
Email: fo@chemphtec.com
Country: United States
ProdList: 2181
Advantage: 58

Oakwood Products, Inc.

Tel: --
Fax: --
Email: sales@oakwoodchemical.com
Country: United States
ProdList: 6193
Advantage: 74

OChem Incorporation

Tel: --
Fax: --
Email: sales@ocheminc.com
Country: United States
ProdList: 6501
Advantage: 60

RIA International LLC

Tel: --
Fax: --
Email: marketing@riausa.net
Country: United States
ProdList: 1324
Advantage: 50

BroadPharm. Inc.

Tel: --
Fax: --
Email: sales@broadpharm.com
Country: United States
ProdList: 891
Advantage: 50

Ontario Chemicals, Inc

Tel: --
Fax: --
Email: info@ontariochem.com
Country: United States
ProdList: 723
Advantage: 50

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Synthonix

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 1423
Advantage: 68

Angene International Limited

Tel: --
Fax: --
Email: sales@angenechemical.com
Country: United States
ProdList: 100
Advantage: 50

Wilshire Chemical Company Inc.

Tel: --
Fax: --
Email: WilshrChem@AOL.COM
Country: United States
ProdList: 3498
Advantage: 58

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Ryan Scientific, Inc.

Tel: --
Fax: --
Email: ryan.reichlyn@ryansci.com
Country: United States
ProdList: 6439
Advantage: 60

AstaTech, Inc

Tel: --
Fax: --
Email: sales@astatechinc.com
Country: United States
ProdList: 6371
Advantage: 58

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

Parkway Scientific

Tel: --
Fax: --
Email: sales@parkwayscientific.com
Country: United States
ProdList: 377
Advantage: 46

Focus Synthesis LLC

Tel: --
Fax: --
Email: acd@focussynthesis.com
Country: United States
ProdList: 2487
Advantage: 61

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

More

Less

View Lastest Price from 3-Oxocyclobutanecarboxylic acid manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 3-Oxocyclobutanecarboxylic acid 23761-23-1
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-15

Hebei Weibang Biotechnology Co., Ltd

Product: 3-Oxocyclobutanecarboxylic acid 23761-23-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-14

Hebei Dangtong Import and export Co LTD

Product: 3-Oxocyclobutanecarboxylic acid 23761-23-1
Price: US $874.00-862.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 100Tons
Release date: 2023-03-02

23761-23-1, 3-Oxocyclobutanecarboxylic acidRelated Search:

1-DODECANESULFONIC ACID SODIUM SALT TRIMETHYLENE OXIDE 1-Bromobutane Sodium dodecyl sulfate Cyclopropane 1-Hexadecylpyridinium bromide 2-Bromo-2-methylpropane 1-Chloro-2-methylpropane Folic acid Oxygen-fluorine acid Stearic acid Ethyl 2-(Chlorosulfonyl)acetate Levofloxacin carboxylic acid 2-Chloro-2-methylpropane Citric acid Ascoric Acid Cyclobutanecarboxylic acid Cyclobutanemethanol

3-OXO-CYCLOBUTANECARBOXYLIC ACID

(3-oxocyclobutyl)carboxylic acid

3-Oxycyclobutanecarboxylic acid

3-Oxo-cyclobutanecarboxylic acid ,95%

3-Oxocyclobutanecarboxyli...

3-oxocyclobutanecarboxylic acid(SALTDATA: FREE)

3-Oxocyclobutane-1-carboxylic acid 98%

IFLAB-BB F2124-0041

CYCLOBUTANECARBOXYLIC ACID, 3-OXO-

3-Oxocyclobutanecarboxylic

1-Carboxy-3-oxocyclobutane

3-oxocyclobutane-1-carboxylic acid

3-Oxocyclobutanecarboxylic acid 98%

3-oxocyclobutane-1,1-dicarboxylic acid

3-Oxo-1-cyclobutanecarboxylic Acid

3-Oxocyclobutanecarboxylic Acid, 97+%

cyclobutanone-3-carboxylic acid

3-OxocyclobutanecarboxylicAcid&gt

3-OxocycL

3-oxo-cyclobutylkylcarboxylic acid

CAS 23761-23-1 3-Oxocyclobutanecarboxylic acid

Oxocyclobutanecarboxylic acid

3-Oxocyclobutanyl carboxylic acid

3-0xocyclobutanecarboxylic acid

23761-23-1

Building Blocks/Intermediates

API intermediates

Pharmaceutical intermediate

Miscellaneous Reagents