2-Bromo-5-fluoroaniline

ChemicalBook > CAS DataBase List > 2-Bromo-5-fluoroaniline

2-Bromo-5-fluoroaniline

Product Name: 2-Bromo-5-fluoroaniline
CAS No.: 1003-99-2
Chemical Name: 2-Bromo-5-fluoroaniline
Synonyms: 2-Bromo-5-fluoro-phenylamine;2-Bromo-5-fluoroanil;Vandetanib Impurity 3;2-BROMO-5-FLUOROANILINE;13-Cyanophenyl&isocyanate;2-Bromo-5-fluoroaniline98%;2-Bromo-5-fluoroaniline >2-Bromo-5-fluoroaniline 98%;2-BROMO-5-FLUOROBENZENAMINE;2-Bromo-5-fluoroaniline,99%
CBNumber: CB0184425
Molecular Formula: C6H5BrFN
Formula Weight: 190.01
MOL File: 1003-99-2.mol

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2-Bromo-5-fluoroaniline Property

Melting point:: 43-47 °C (lit.)
Boiling point:: 154 °C / 23mmHg
Density: 1.694±0.06 g/cm3(Predicted)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 1.52±0.10(Predicted)
color: White to Light yellow to Dark green
InChI: InChI=1S/C6H5BrFN/c7-5-2-1-4(8)3-6(5)9/h1-3H,9H2
InChIKey: FWTXFEKVHSFTDQ-UHFFFAOYSA-N
SMILES: C1(N)=CC(F)=CC=C1Br
CAS DataBase Reference: 1003-99-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: UN2811
WGK Germany: 3
Hazard Note: Toxic
HazardClass: 6.1
PackingGroup: III
HS Code: 29214200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 528900
Product name: 2-Bromo-5-fluoroaniline
Purity: 97%
Packaging: 25g
Price: $50.4
Updated: 2023/01/07

TCI Chemical

Product number: B2163
Product name: 2-Bromo-5-fluoroaniline
Purity: >98.0%(GC)
Packaging: 5g
Price: $56
Updated: 2024/03/01

TCI Chemical

Product number: B2163
Product name: 2-Bromo-5-fluoroaniline
Purity: >98.0%(GC)
Packaging: 25g
Price: $166
Updated: 2024/03/01

Alfa Aesar

Product number: B24901
Product name: 2-Bromo-5-fluoroaniline, 98%
Packaging: 5g
Price: $51.65
Updated: 2024/03/01

Alfa Aesar

Product number: B24901
Product name: 2-Bromo-5-fluoroaniline, 98%
Packaging: 25g
Price: $190.65
Updated: 2024/03/01

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2-Bromo-5-fluoroaniline Chemical Properties,Usage,Production

Description

2-bromo-5-fluoroaniline: a intermediate of antitumor drug.
2-bromo-5-fluoroaniline is the intermediate of antitumor drug Phortress, phortress is the benzothiazoles CYP1A1 antitumor drugs targeting by Univ Nottingham UK invention, solution becomes lipophilic compound 5F2O3(10 in the sensitive cells but Phortress enters), the latter is as potential aromatic hydrocarbon receptor (AhR) agonist, induce CYP1A1 to express, CYP1A1 metabolism through expressing produces and has high electrophilic active substance again, finally causes DNA damage and apoptosis. The method that, at present, synthetic 2-bromo-5-fluoronitrobenzene prepares 2-bromo-5-fluoroaniline is divided into two large classes:
The one: adopt a chemical reduction method, utilizing the chemical reducing agent reductase 2-bromo-5-fluoronitrobenzenes such as protochloride glass putty, iron powder, vat powder, hydrazine, and sodium borohydride (potassium), which is 2-bromo-5-fluoroaniline.
The 2nd: adopt hydro-reduction. What we do more often both at home and abroad at present is chloride or the catalytic hydrogenation of fluorine-containing arylamine, and the brominated less report of arylamine hydrogenation mainly is easily by hydrogenolysis because of bromine.

Chemical Properties

Yellow to brown crystalline powder

Uses

2-Bromo-5-fluoroaniline may be used to synthesize:

orthobromothiobenzanilide of 5-fluoronitrobenzothiazole
2-bromo-5-fluorobenzo[¹⁴C]nitrile
[3-¹⁴C]-5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
2-bromo-5-fluoro-phenyl)-(2-methoxy-6-pentadecyl-benzyl)amine

Synthesis

A preparation method of 2-Bromo-5-fluoroaniline is as follows: methanol, 2-bromo-5-fluoronitrobenzene, W-4 type Raney nickel and bromine inhibitor are put into a hydrogenation kettle to carry out hydrogenation reaction. After the reaction is completed, the reaction solution is filtered under nitrogen protection. The filtered filtrate is then distilled under reduced pressure to remove methanol, and n-hexane is added. Then, the product is washed with process water, and after washing, the product is allowed to stand and separate. Then, the organic phase is cooled and crystallized, an off-white to brownish-yellow solid is precipitated, and a wet product is obtained by suction filtration. The wet product is dried to obtain the finished product 2-Bromo-5-fluoroaniline.

2-Bromo-5-fluoroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Bromo-5-fluoroaniline manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: 2-Bromo-5-fluoroaniline 1003-99-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-18

Suzhou Nordica Biopharma CO.,LTD

Product: 2-bromo-5-fluoroaniline 1003-99-2
Price: US $0.00-0.00/kg
Min. Order: 0.005kg
Purity: 0.98
Supply Ability: 2 tons
Release date: 2024-11-15

Hebei Weibang Biotechnology Co., Ltd

Product: 2-Bromo-5-fluoroaniline 1003-99-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-11

1003-99-2, 2-Bromo-5-fluoroanilineRelated Search:

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2-BROMO-5-FLUOROBENZENAMINE

2-BROMO-5-FLUOROANILINE

2-Bromo-5-fluoro-phenylamine

2-Bromo-5-fluoroaniline 98%

2-Bromo-5-fluoroaniline98%

2-Bromo-5-fluoroaniline,99%

2-Bromo-5-fluoroanil

BenzenaMine, 2-broMo-5-fluoro-

2-BroMo-5-fluoroaniline, 99% 25GR

2-broMo-5-fluoroaniline, 2-broMo-5-fluoro-phenylaMine, 2-broMo-5-fluorobenzeneaMine, 2-broMo-5-fluorobenzenaMine, 2-broMo-5-fluoro aniline, 2-broMo-5-fluoro-aniline, 2-BroM-5-fluor-anilin

2-Bromo-5-fluoroaniline &gt

2-Bromo-5-fluoroaniline ISO 9001：2015 REACH

13-Cyanophenyl&isocyanate

Vandetanib Impurity 3

Nitazoxanide Impurity 4（SU 3327）

1003-99-2

Nitrogen Compounds

Organic Building Blocks

C2 to C6

Amines

Building Blocks

amine| alkyl bromide| alkyl Fluorine

Aryl Fluorinated Building Blocks

Building Blocks

Chemical Synthesis

Fluorinated Building Blocks

Nitrogen Compounds

Organic Building Blocks

Organic Fluorinated Building Blocks

Other Fluorinated Organic Building Blocks

Amines

C2 to C6

Nitrogen Compounds

Aniline

Anilines, Amides & Amines

Bromine Compounds

Fluorine Compounds

Pharmaceutical intermediate

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