ChemicalBook > CAS DataBase List > 2,4-DICHLORO-5-NITROPYRIDINE

2,4-DICHLORO-5-NITROPYRIDINE

Product Name
2,4-DICHLORO-5-NITROPYRIDINE
CAS No.
4487-56-3
Chemical Name
2,4-DICHLORO-5-NITROPYRIDINE
Synonyms
oro-5-nitropyridine;4-DICHLORO-5-NITROPYRIDINE;2,4-DICHLORO-5-NITROPYRIDINE;5-nitro-2,4-dichloro pyridine;2,4-DIHYDROXY-5-NITROPYRIDINE;Pyridine, 2,4-dichloro-5-nitro-;2,4-Dichloro-5-nitropyridine >2,4-Dichloro-5-nitropyridine ,95%;2,4-Dichloro-5-Nitropyridine(WXC02234);4-chloro-5-methyl-3-nitropyridin-2-amine
CBNumber
CB0231226
Molecular Formula
C5H2Cl2N2O2
Formula Weight
192.99
MOL File
4487-56-3.mol
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2,4-DICHLORO-5-NITROPYRIDINE Property

Melting point:
42.0 to 46.0 °C
Boiling point:
282.3±35.0 °C(Predicted)
Density 
1.629±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
-2.49±0.10(Predicted)
color 
Light orange to Yellow to Green
InChI
InChI=1S/C5H2Cl2N2O2/c6-3-1-5(7)8-2-4(3)9(10)11/h1-2H
InChIKey
RZVJQUMDJUUBBF-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C([N+]([O-])=O)C(Cl)=C1
CAS DataBase Reference
4487-56-3
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Safety

Hazard Codes 
Xi,T
Risk Statements 
25
Safety Statements 
45
RIDADR 
2811
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D4752
Product name
2,4-Dichloro-5-nitropyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$48
Updated
2025/07/31
TRC
Product number
D436130
Product name
2,4-Dichloro-5-nitropyridine
Packaging
1g
Price
$195
Updated
2021/12/16
TRC
Product number
D436130
Product name
2,4-Dichloro-5-nitropyridine
Packaging
5g
Price
$605
Updated
2021/12/16
TRC
Product number
D436130
Product name
2,4-Dichloro-5-nitropyridine
Packaging
10g
Price
$1075
Updated
2021/12/16
SynQuest Laboratories
Product number
4H54-5-W1
Product name
2,4-Dichloro-5-nitropyridine
Purity
97%
Packaging
1g
Price
$31
Updated
2021/12/16
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2,4-DICHLORO-5-NITROPYRIDINE Chemical Properties,Usage,Production

Chemical Properties

Light yellow needles

Uses

2,4-Dichloro-5-nitropyridine is used in the synthesis of potent and selective stearoyl-CoA desaturase (SCD) inhibitors. Also used in preparation of Rho-Kinase inhibitors displaying antihypertensive activity.

Synthesis

850663-54-6

4487-56-3

Step 3. Synthesis of 2,4-dichloro-5-nitropyridine: The product of step 2, 2-hydroxy-4-chloro-5-nitropyridine (40.0 g, 229 mmol), was suspended in toluene (300 mL), and phosphorus oxychloride (POCl3, 65 mL, 697 mmol) was added dropwise over a period of 10 min. Subsequently, the reaction mixture was heated to reflux and maintained for 6 hours. Upon completion of the reaction, the mixture was cooled to 60 °C and stirred continuously at this temperature overnight. The non-homogeneous reaction mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The residue was carefully adjusted to an alkaline pH with saturated aqueous potassium carbonate (K2CO3). extraction was carried out with ethyl acetate (EtOAc), the organic phases were combined and washed sequentially with water and saturated brine. The organic layer was dried over anhydrous sodium sulfate (Na2SO4), filtered and the filtrate was concentrated to give the crude product as an oil. Purification by silica gel column chromatography (eluent: hexane solution of 50% ethyl acetate) afforded the title compound 2,4-dichloro-5-nitropyridine (32.5 g, 74% yield) as an orange oil, which solidified to a solid on standing. Mass spectrometry (electrospray positive ion mode, ES+) showed the molecular ion peak m/e 194 [M+H]+.

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 1, p. 2 - 5
[2] Patent: WO2005/37197, 2005, A2. Location in patent: Page/Page column 84
[3] Patent: WO2005/37197, 2005, A2. Location in patent: Page/Page column 84
[4] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 2, p. 404 - 410
[5] Patent: EP2818472, 2014, A1. Location in patent: Paragraph 0126; 0128

2,4-DICHLORO-5-NITROPYRIDINE Preparation Products And Raw materials

Raw materials

Potassium tert-butoxide tert-Butyl hydroperoxide Phosphorus oxitrichloride 4-Hydroxypyridine Tetrahydrofuran Nitric acid Sulfuric acid

Preparation Products

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2,4-DICHLORO-5-NITROPYRIDINE Suppliers

Americas 1 Canada 1 China 246 Europe 2 France 3 Germany 4 India 22 Japan 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 10 United States 37 Global 330
P&S Chemicals
Tel
--
Fax
--
Email
info@pschemicals.com
Country
The Netherlands
ProdList
2724
Advantage
58
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View Lastest Price from 2,4-DICHLORO-5-NITROPYRIDINE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2,4-DICHLORO-5-NITROPYRIDINE 4487-56-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27
Henan Fengda Chemical Co., Ltd
Product
2,4-Dichloro-5-nitropyridine 4487-56-3
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30
Dideu Industries Group Limited
Product
2,4-DICHLORO-5-NITROPYRIDINE 4487-56-3
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-07

4487-56-3, 2,4-DICHLORO-5-NITROPYRIDINERelated Search:

2,4-Dichloro-6-methylpyrimidine 2,4-Dichloro-6-picoline 2,4-Dichloro-5-nitropyrimidine 3,5-DICHLORO-4-NITROPYRIDINE N-OXIDE 2,6-Dichloro-3-nitropyridine 4,6-dichloro-5-nitropyridine 2,3-DICHLORO-5-NITROPYRIDINE 3,5-DICHLORO-4-NITROPYRIDINE 3-Amino-4-chloropyridine 4,6-DICHLORO-PYRIDIN-3-YLAMINE 2,4-DICHLORO-5-NITROPYRIDINE 2 6-DICHLORO-4-NITROPYRIDINE 97 (3alpha)-3-chloro-Cholest-4-ene 2,5-DICHLORO-3-NITROPYRIDINE 4-Chloro-3-nitropyridine hydrochloride 4-Chloro-3-nitropyridine 4-Chloro-2,6-dimethyl-3-nitropyridine 4-AMINO-2,6-DICHLORO-3-NITROPYRIDINE

  • 2,4-DICHLORO-5-NITROPYRIDINE
  • 4-chloro-5-methyl-3-nitropyridin-2-amine
  • 2,4-DIHYDROXY-5-NITROPYRIDINE
  • Pyridine, 2,4-dichloro-5-nitro-
  • 2,4-Dichloro-5-nitropyridine ,95%
  • 5-nitro-2,4-dichloro pyridine
  • 2,4-Dichloro-5-Nitropyridine(WXC02234)
  • 2,4-Dichloro-5-nitropyridine &gt
  • oro-5-nitropyridine
  • 2,4-DICHLORO-5-NITROPYRIDINE ISO 9001：2015 REACH
  • 4-DICHLORO-5-NITROPYRIDINE
  • 4487-56-3