ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE

Product Name: ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE
CAS No.: 87121-89-9
Chemical Name: ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE
Synonyms: Ethyl 3-oxetanecarboxylate;Ethyl oxetane-3-carboxylate;Ethyl 3-Oxocyclobutylcarboxylate;Ethyl 3-oxocyclobuantecarboxylate;ethyl 3-oxocyclobutanecarboxylate;ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE;ethyl 3-oxocyclobutane-1-carboxylate;Ethyl 3-oxocyclobutanecarboxylate, 95%;Methyl 3,3,3-trifluoro-2-iminopropanoate;3-Oxo-cyclobutanecarboxylic acid ethyl ester
CBNumber: CB02451008
Molecular Formula: C7H10O3
Formula Weight: 142.15
MOL File: 87121-89-9.mol

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ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE Property

Boiling point:: 90 °C(Press: 2 Torr)
Density: 1.169g/ml
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: liquid
color: light brown
InChI: InChI=1S/C7H10O3/c1-2-10-7(9)5-3-6(8)4-5/h5H,2-4H2,1H3
InChIKey: BXBRFSMPBOTZHJ-UHFFFAOYSA-N
SMILES: C1(C(OCC)=O)CC(=O)C1
CAS DataBase Reference: 87121-89-9

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Safety

HS Code: 2916200090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

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N-Bromosuccinimide Price

TRC

Product number: E925368
Product name: Ethyl3-oxocyclobutanecarboxylate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: E925368
Product name: Ethyl3-oxocyclobutanecarboxylate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Usbiological

Product number: 449135
Product name: Ethyl 3-oxocyclobutanecarboxylate
Packaging: 100mg
Price: $305
Updated: 2021/12/16

AK Scientific

Product number: W8940
Product name: Ethyl3-oxocyclobutanecarboxylate
Packaging: 10g
Price: $94
Updated: 2021/12/16

AK Scientific

Product number: J97640
Product name: Ethyl3-oxocyclobutanecarboxylate
Packaging: 10g
Price: $70
Updated: 2021/12/16

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ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE Chemical Properties,Usage,Production

Uses

Ethyl 3-oxocyclobutanecarboxylate is used as pharmaceutical intermediate.

Synthesis

17205-02-6

87121-89-9

The general procedure for the synthesis of ethyl 3-oxocyclobutanecarboxylate from ethyl 3-hydroxycyclobutanecarboxylate was as follows: oxalyl chloride (1.79 mL, 21.2 mmol) was slowly added to dichloromethane (100 mL) at -78 °C, followed by dimethyl sulfoxide (2.51 mL, 35.3 mmol). After 30 minutes of reaction, a solution of cis- and trans-3-hydroxycyclobutanecarboxylic acid ethyl ester (2.68 g, 17.6 mmol) in dichloromethane (46 mL) was added dropwise. The reaction mixture was kept stirred at -78 °C for 30 min. After that, triethylamine (9.84 mL, 70.6 mmol) was added. The reaction mixture was slowly warmed up to room temperature over 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of water and the organic and aqueous layers were separated. The organic layer was washed sequentially with 1N HCl, water, saturated sodium bicarbonate solution and brine, dried over anhydrous sodium sulfate, filtered and concentrated. The resulting crude product, ethyl 3-oxocyclobutanecarboxylate (2.36 g, 94% yield), could be used in the subsequent reaction without further purification. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 4.21 (q, 2H), 3.45-3.37 (m, 2H), 3.33-3.17 (m, 3H), 1.29 (t, 3H).

References

[1] Patent: US2009/233903, 2009, A1. Location in patent: Page/Page column 43
[2] Chemische Berichte, 1957, vol. 90, p. 1424,1427
[3] Journal of Organic Chemistry, 1968, vol. 33, # 5, p. 1959 - 1962

ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE Suppliers

China 129 India 5 United Kingdom 1 United States 11 Global 146

Alchem Pharmtech,Inc.

Tel: 8485655694
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SynQuest Laboratories, Inc.

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Matrix Scientific

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Focus Synthesis LLC

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Synthonix

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Parkway Scientific

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View Lastest Price from ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE manufacturers

PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD

Product: 3-Oxocyclobutanecarboxylic acid ethyl ester 87121-89-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2 MTs
Release date: 2024-08-06

Career Henan Chemical Co

Product: ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE 87121-89-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-24

Career Henan Chemical Co

Product: ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE 87121-89-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 1000kg
Release date: 2018-12-24

87121-89-9, ETHYL 3-OXO CYCLOBUATNE CARBOXYLATERelated Search:

3-Oxocyclobutanecarboxylic acid METHYL 3-OXOCYCLOBUTANECARBOXYLATE Cyclobutanecarboxylic acid, 3-methylene-, methyl ester (6CI,8CI,9CI) Carbamic acid, (3-oxocyclobutyl)-, 1,1-dimethylethyl ester (9CI) ETHYL 3-OXOCYCLOHEXANE-1-CARBOXYLATE ethyl 3-oxocyclopentane-1-carboxylate 1-N-Ethoxycarbonyl-3-pyrrolidone Methyl 3-hydroxycyclobuta... BENZYL 3-OXOCYCLOBUTYLCARBAMATE T-butyl-3-oxocyclobutanecarboxylate 3-Hydroxy-cyclobutanecarboxylic acid ethyl ester 3-HYDROXYCYCLOBUTANECARBOXYLIC ACID tert-butyl 3-hydroxycyclobutanecarboxylate Ethyl cyclobutanecarboxylate Cyclobutanone 3-(HYDROXYMETHYL)CYCLOBUTAN-1-ONE ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE

ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE

ethyl 3-oxocyclobutanecarboxylate

3-Oxo-cyclobutanecarboxylic acid ethyl ester

Cyclobutanecarboxylic acid, 3-oxo-, ethyl ester

Ethyl oxetane-3-carboxylate

Methyl 3,3,3-trifluoro-2-iminopropanoate

Ethyl 3-oxocyclobuantecarboxylate

ethyl 3-oxocyclobutane-1-carboxylate

3-oxo-1-cyclobutanecarboxylic acid ethyl ester

Ethyl 3-Oxocyclobutylcarboxylate

Ethyl 3-oxetanecarboxylate

Ethyl 3-oxocyclobutanecarboxylate, 95%

87121-89-9