ChemicalBook > CAS DataBase List > N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea

N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea

Product Name: N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea
CAS No.: 1057249-41-8
Chemical Name: N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea
Synonyms: CS-901;SNS-314;SNS314;SNS 314;SNS-314 free base;1-(3-chlorophenyl)-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea;1-(3-chlorophenyl)-3-(4-(2-(thieno[3,2-d]pyriMidin-4-ylaMino)ethyl)thiazol-2-yl)urea;N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea;Urea, N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]-
CBNumber: CB02484770
Molecular Formula: C18H15ClN6OS2
Formula Weight: 430.93
MOL File: 1057249-41-8.mol

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N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea Property

Density: 1.588
storage temp.: Store at -20°C
solubility: DMSO: 100 mg/mL (232.06 mM);Ethanol: Insoluble
pka: 6.12±0.70(Predicted)
Water Solubility: Water: Insoluble
InChI: InChI=1S/C18H15ClN6OS2/c19-11-2-1-3-12(8-11)24-17(26)25-18-21-9-13(28-18)4-6-20-16-15-14(5-7-27-15)22-10-23-16/h1-3,5,7-10H,4,6H2,(H,20,22,23)(H2,21,24,25,26)
InChIKey: FAYAUAZLLLJJGH-UHFFFAOYSA-N
SMILES: N(C1=CC=CC(Cl)=C1)C(NC1=NC=C(CCNC2N=CN=C3C=CSC3=2)S1)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: S590110
Product name: SNS-314
Packaging: 100mg
Price: $1155
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0000485
Product name: SNS-314
Purity: 95.00%
Packaging: 1MG
Price: $203.7
Updated: 2021/12/16

Adipogen Life Sciences

Product number: SYN-1081-M010
Product name: SNS-314
Purity: ≥95%
Packaging: 10mg
Price: $216
Updated: 2021/12/16

AK Scientific

Product number: SYN1081
Product name: SNS-314
Packaging: 50mg
Price: $670
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 61740
Product name: SNS-314
Packaging: 10mg
Price: $700
Updated: 2021/12/16

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N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea Chemical Properties,Usage,Production

Uses

SNS-314 is used in the synthesis of AuroraA kinase inhibitors used in cancer treatment.

Definition

ChEBI: 1-(3-chlorophenyl)-3-[5-[2-(4-thieno[3,2-d]pyrimidinylamino)ethyl]-2-thiazolyl]urea is a member of ureas.

in vivo

In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 leads to dose-dependent inhibition of histone H3 phosphorylation for at least 10 h. SNS-314 shows significant tumor growth inhibition in a dose dependent manner under a variety of dosing schedules including weekly, bi-weekly, and 5 days on/9 days off^[2].

IC 50

Aurora A: 9 nM (IC₅₀); Aurora B: 31 nM (IC₅₀); Aurora C: 6 nM (IC₅₀)

N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea manufacturers

Career Henan Chemical Co

Product: N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea 1057249-41-8
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-21

1057249-41-8, N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]ureaRelated Search:

FORMANILIDE 4-Aminodiphenylamine SNDX-5613 SNS-032 N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide hydrochloride TDZD-8 4SC-202 CEP-32496 N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine PURVALANOL A Testolactone GDC-0077 AGI6780 CC0651 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine IDO-IN-7 UNC 0631

N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea

SNS-314

1-(3-chlorophenyl)-3-(4-(2-(thieno[3,2-d]pyriMidin-4-ylaMino)ethyl)thiazol-2-yl)urea

SNS314;SNS 314

CS-901

Urea, N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]-

1-(3-chlorophenyl)-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea

SNS-314 free base

1057249-41-8

C18H15ClN6OS2

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