4-BROMO-TETRAHYDROPYRAN

Product Name: 4-BROMO-TETRAHYDROPYRAN
CAS No.: 25637-16-5
Chemical Name: 4-BROMO-TETRAHYDROPYRAN
Synonyms: 4-Bromotetrahydro-2H-pyran;4-broMooxane;?CB0257673;4-Bromooxacyclohexane;4-Bromotetrahyropyran;4-BROMO-TETRAHYDROPYRAN;4-Bromo-tetrahydropyran ,98%;2H-Pyran, 4-bromotetrahydro-;4-BroMotetrahydro-2H-pyra...;4-BROMO-TETRAHYDROPYRAN ISO 9001：2015 REACH
CBNumber: CB0257673
Molecular Formula: C5H9BrO
Formula Weight: 165.03
MOL File: 25637-16-5.mol

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4-BROMO-TETRAHYDROPYRAN Property

Boiling point:: 178℃
Density: 1.467 g/cm3 at 25 °C
refractive index: n20/D1.497
Flash point:: 69℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: clear liquid
color: Colorless to Yellow to Orange
InChI: InChI=1S/C5H9BrO/c6-5-1-3-7-4-2-5/h5H,1-4H2
InChIKey: IVBVKTPDEWDNRW-UHFFFAOYSA-N
SMILES: C1OCCC(Br)C1
CAS DataBase Reference: 25637-16-5

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 2
HS Code: 29321900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 722456
Product name: 4-Bromotetrahydropyran
Packaging: 500mg
Price: $90
Updated: 2025/07/31

TCI Chemical

Product number: B5600
Product name: 4-Bromotetrahydro-2H-pyran
Purity: >98.0%(GC)
Packaging: 1g
Price: $68
Updated: 2025/07/31

TCI Chemical

Product number: B5600
Product name: 4-Bromotetrahydro-2H-pyran
Purity: >98.0%(GC)
Packaging: 5g
Price: $200
Updated: 2025/07/31

TRC

Product number: B688308
Product name: 4-Bromo-tetrahydropyran
Packaging: 1g
Price: $45
Updated: 2021/12/16

Oakwood

Product number: 077342
Product name: 4-Bromotetrahydropyran
Purity: 98%
Packaging: 1g
Price: $12
Updated: 2021/12/16

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4-BROMO-TETRAHYDROPYRAN Chemical Properties,Usage,Production

Chemical Properties

Light yellow liquid

Uses

Reactant for:

Nickel-catalyzed alkyl-alkyl Suzuki coupling reactions with boron reagents
Preparation of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans
Preparation of aliphatic hydrocarbons via nickel-catalyzed Suzuki cross-coupling with alkylboranes
Preparation of anthranilic acids as antibacterial agents with human serum albumin binding affinity
Preparation of antiatherogenic antioxidant di-tert-butyldihydrobenzofuranols via Grignard reactions with di-tert-butyl(hydroxy)benzaldehyde derivatives
Synthesis of gephyrotoxin via the Schmidt reaction

Uses

4-Bromo-tetrahydropyran is a useful reactant in organic synthesis.

Synthesis

2081-44-9

25637-16-5

General procedure for the synthesis of 4-bromotetrahydropyran from tetrahydropyran-4-ol: A. Preparation of 4-bromotetrahydropyran. Tetrahydropyran-4-ol (1.0 g, 10 mmol), carbon tetrabromide (3.6 g, 11 mmol) and triphenylphosphine (3.1 g, 12 mmol) were dissolved in dichloromethane (25 mL) and the reaction was stirred at room temperature overnight. Upon completion of the reaction, the crude reaction mixture was concentrated and subsequently purified by rapid chromatography on silica gel (eluent ratio ethyl acetate:hexane = 1:20) to afford the target product 4-bromotetrahydropyran as a colorless oil (1.4 g, 87% yield).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 7, p. 2780 - 2789
[2] Patent: WO2005/9973, 2005, A1. Location in patent: Page/Page column 85; 86
[3] Angewandte Chemie - International Edition, 2007, vol. 46, # 19, p. 3556 - 3558
[4] Justus Liebigs Annalen der Chemie, 1937, vol. 532, p. 80
[5] Chem.Abstr., 1940, p. 4396

4-BROMO-TETRAHYDROPYRAN Preparation Products And Raw materials

Raw materials

Tetrahydro-4-pyranol Phosphorus tribromide Pyridine

Preparation Products

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4-BROMO-TETRAHYDROPYRAN Suppliers

Americas 1 Austria 1 China 170 Europe 1 India 5 Japan 1 United Kingdom 2 United States 18 Global 199

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

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View Lastest Price from 4-BROMO-TETRAHYDROPYRAN manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Bromo-tetrahydropyran 25637-16-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-22

Dideu Industries Group Limited

Product: 4-BROMO-TETRAHYDROPYRAN 25637-16-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-29

Career Henan Chemical Co

Product: 4-Bromo-tetrahydropyran 25637-16-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 500kg
Release date: 2018-08-16

25637-16-5, 4-BROMO-TETRAHYDROPYRANRelated Search:

TETRAHYDRO-2H-PYRAN-3-OL 4-IODOTETRAHYDRO-2H-PYRAN (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL 3,4-Dihydro-2H-pyran TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE Tetrahydro-2H-pyran-4-carboxylic acid 4-Aminotetrahydropyran Tetrahydro-4H-pyran-4-one 3,6-dihydro-2H-pyran Methyl tetrahydropyran-4-carboxylate 2-methyloxan-4-one Tetrahydro-4-pyranol 4-BROMOMETHYLTETRAHYDROPYRAN Tetrahydropyran 4-BROMO-TETRAHYDROPYRAN

4-BROMO-TETRAHYDROPYRAN

4-Bromotetrahyropyran

4-broMooxane

4-Bromooxacyclohexane

4-Bromotetrahydro-2H-pyran

4-BroMotetrahydro-2H-pyra...

2H-Pyran, 4-bromotetrahydro-

4-Bromo-tetrahydropyran ,98%

?CB0257673

4-BROMO-TETRAHYDROPYRAN ISO 9001：2015 REACH

25637-16-5

75637-16-5

Organohalides

Pyran

Halides

Heterocycles