ChemicalBook > CAS DataBase List > 4-BROMO-TETRAHYDROPYRAN

4-BROMO-TETRAHYDROPYRAN

Product Name
4-BROMO-TETRAHYDROPYRAN
CAS No.
25637-16-5
Chemical Name
4-BROMO-TETRAHYDROPYRAN
Synonyms
4-Bromotetrahydro-2H-pyran;4-broMooxane;?CB0257673;4-Bromooxacyclohexane;4-Bromotetrahyropyran;4-BROMO-TETRAHYDROPYRAN;4-Bromo-tetrahydropyran ,98%;2H-Pyran, 4-bromotetrahydro-;4-BroMotetrahydro-2H-pyra...;4-BROMO-TETRAHYDROPYRAN ISO 9001：2015 REACH
CBNumber
CB0257673
Molecular Formula
C5H9BrO
Formula Weight
165.03
MOL File
25637-16-5.mol
More
Less

4-BROMO-TETRAHYDROPYRAN Property

Boiling point:
178℃
Density 
1.467 g/cm3 at 25 °C
refractive index 
n20/D1.497
Flash point:
69℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
clear liquid
color 
Colorless to Yellow to Orange
InChI
InChI=1S/C5H9BrO/c6-5-1-3-7-4-2-5/h5H,1-4H2
InChIKey
IVBVKTPDEWDNRW-UHFFFAOYSA-N
SMILES
C1OCCC(Br)C1
CAS DataBase Reference
25637-16-5
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
2
HS Code 
29321900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
722456
Product name
4-Bromotetrahydropyran
Packaging
500mg
Price
$90
Updated
2025/07/31
TCI Chemical
Product number
B5600
Product name
4-Bromotetrahydro-2H-pyran
Purity
>98.0%(GC)
Packaging
1g
Price
$68
Updated
2025/07/31
TCI Chemical
Product number
B5600
Product name
4-Bromotetrahydro-2H-pyran
Purity
>98.0%(GC)
Packaging
5g
Price
$200
Updated
2025/07/31
TRC
Product number
B688308
Product name
4-Bromo-tetrahydropyran
Packaging
1g
Price
$45
Updated
2021/12/16
Oakwood
Product number
077342
Product name
4-Bromotetrahydropyran
Purity
98%
Packaging
1g
Price
$12
Updated
2021/12/16
More
Less

4-BROMO-TETRAHYDROPYRAN Chemical Properties,Usage,Production

Chemical Properties

Light yellow liquid

Uses

Reactant for:

  • Nickel-catalyzed alkyl-alkyl Suzuki coupling reactions with boron reagents
  • Preparation of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans
  • Preparation of aliphatic hydrocarbons via nickel-catalyzed Suzuki cross-coupling with alkylboranes
  • Preparation of anthranilic acids as antibacterial agents with human serum albumin binding affinity
  • Preparation of antiatherogenic antioxidant di-tert-butyldihydrobenzofuranols via Grignard reactions with di-tert-butyl(hydroxy)benzaldehyde derivatives
  • Synthesis of gephyrotoxin via the Schmidt reaction

Uses

4-Bromo-tetrahydropyran is a useful reactant in organic synthesis.

Synthesis

2081-44-9

25637-16-5

General procedure for the synthesis of 4-bromotetrahydropyran from tetrahydropyran-4-ol: A. Preparation of 4-bromotetrahydropyran. Tetrahydropyran-4-ol (1.0 g, 10 mmol), carbon tetrabromide (3.6 g, 11 mmol) and triphenylphosphine (3.1 g, 12 mmol) were dissolved in dichloromethane (25 mL) and the reaction was stirred at room temperature overnight. Upon completion of the reaction, the crude reaction mixture was concentrated and subsequently purified by rapid chromatography on silica gel (eluent ratio ethyl acetate:hexane = 1:20) to afford the target product 4-bromotetrahydropyran as a colorless oil (1.4 g, 87% yield).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 7, p. 2780 - 2789
[2] Patent: WO2005/9973, 2005, A1. Location in patent: Page/Page column 85; 86
[3] Angewandte Chemie - International Edition, 2007, vol. 46, # 19, p. 3556 - 3558
[4] Justus Liebigs Annalen der Chemie, 1937, vol. 532, p. 80
[5] Chem.Abstr., 1940, p. 4396

4-BROMO-TETRAHYDROPYRAN Preparation Products And Raw materials

Raw materials

Tetrahydro-4-pyranol Phosphorus tribromide Pyridine

Preparation Products

More
Less

4-BROMO-TETRAHYDROPYRAN Suppliers

Americas 1 Austria 1 China 170 Europe 1 India 5 Japan 1 United Kingdom 2 United States 18 Global 199
ITIC MEDCHEM(SUZHOU) CO.,LTD.
Tel
0512-68323967 18015559028
Fax
+86-512-69200360
Email
sales@iticmedchem.com
Country
China
ProdList
506
Advantage
61
BTC Pharmaceutical CO. Ltd
Tel
15716293042 18862996710
Fax
0513-68015394
Email
15050603958@163.com
Country
China
ProdList
694
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
SpringPharma Tech Co.,Ltd
Tel
+86-25-68710855, +86-25-68710897
Fax
025-68710856
Email
sales@springpharma.net
Country
China
ProdList
1261
Advantage
62
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Shanghai ZaiQi Bio-Tech Co., Ltd.
Tel
021-54824098, 021-37212705 021-37212706, 13391256916
Fax
021-54824069
Email
sales@chemzq.com
Country
China
ProdList
570
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Suzhou Lakestar Pharmatech Co., Ltd.
Tel
0512-63970158-603 18018108880
Fax
0512-63971078
Email
info@lakestarpharma.com
Country
China
ProdList
421
Advantage
59
Chemfun Medical Technology(Shanghai) Co., Ltd.
Tel
021-67220633 021-54824098
Fax
+86-21-54824069
Email
chemfun@chemfun.net
Country
China
ProdList
491
Advantage
58
Mashilabs (Shanghai) Co.,Ltd.
Tel
19916721580
Fax
QQ：3154870176
Email
mafarm@126.com
Country
China
ProdList
4542
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Shanghai Jovan Biochemical Technology Co. Ltd.
Tel
+86-021-61654350
Fax
+86-021-61654350
Email
1245958370@qq.com
Country
China
ProdList
2982
Advantage
50
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Giant chemicals
Tel
028-85434334 18108076537
Fax
QQ：245797092
Email
market@gianthx.com
Country
China
ProdList
4505
Advantage
56
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Chengdu Research Accelerators Technology Co., Ltd.
Tel
028-64353063
Fax
028-64353063 QQ:784253935
Email
reacchemical@163.com
Country
China
ProdList
5253
Advantage
58
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
028-88469284 18000562381
Email
rzbtsj@163.com
Country
China
ProdList
9951
Advantage
56
CHMA Chemical Technology (Shanghai) Co., Ltd
Tel
021-61556450 15800904410
Fax
021-61556450
Country
China
ProdList
2832
Advantage
58
Wuhan Chemwish Technology Co.， Ltd
Tel
027-67849912
Fax
027-87531808
Email
sales@chemwish.com
Country
China
ProdList
9148
Advantage
60
Shanghai Brain Biotechnology Co., Ltd.
Tel
13564638271
Fax
021-68948280
Email
shhjiang1977@163.com
Country
China
ProdList
2987
Advantage
55
Chongqing AoShe Biological Chemical Co., Ltd.
Tel
023-63225655 13320248848
Fax
023-63225655QQ2366581735
Email
2366581735@qq.com
Country
China
ProdList
511
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Chengdu Xiaojia Technology Co., Ltd.
Tel
15902830537
Email
zhanghao@happysyn.com
Country
China
ProdList
3180
Advantage
55
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Guangdong wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2886750 13927877953
Fax
0751-2886750
Email
3005811397@qq.com
Country
China
ProdList
13305
Advantage
58
Zhengzhou Huiju Chemical Co., Ltd.
Tel
0371-55900031 18137872243
Fax
QQ：2853979815
Email
2853979815@qq.com
Country
China
ProdList
9975
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Combiphos (Shanghai) Biological Technology Co., Ltd.
Tel
021-65232103 17602124823
Email
combiphos@vip.qq.com
Country
China
ProdList
30000
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Shanghai WangFa Chemical Technology Co., Ltd.
Tel
13918479294
Fax
-
Email
xiebenfa@163.com
Country
China
ProdList
4087
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10295
Advantage
58
More
Less

View Lastest Price from 4-BROMO-TETRAHYDROPYRAN manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Bromo-tetrahydropyran 25637-16-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
Dideu Industries Group Limited
Product
4-BROMO-TETRAHYDROPYRAN 25637-16-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-29
Career Henan Chemical Co
Product
4-Bromo-tetrahydropyran 25637-16-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
500kg
Release date
2018-08-16

25637-16-5, 4-BROMO-TETRAHYDROPYRANRelated Search:

TETRAHYDRO-2H-PYRAN-3-OL 4-IODOTETRAHYDRO-2H-PYRAN (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL 3,4-Dihydro-2H-pyran TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE Tetrahydro-2H-pyran-4-carboxylic acid 4-Aminotetrahydropyran Tetrahydro-4H-pyran-4-one 3,6-dihydro-2H-pyran Methyl tetrahydropyran-4-carboxylate 2-methyloxan-4-one Tetrahydro-4-pyranol 4-BROMOMETHYLTETRAHYDROPYRAN Tetrahydropyran 4-BROMO-TETRAHYDROPYRAN

  • 4-BROMO-TETRAHYDROPYRAN
  • 4-Bromotetrahyropyran
  • 4-broMooxane
  • 4-Bromooxacyclohexane
  • 4-Bromotetrahydro-2H-pyran
  • 4-BroMotetrahydro-2H-pyra...
  • 2H-Pyran, 4-bromotetrahydro-
  • 4-Bromo-tetrahydropyran ,98%
  • ?CB0257673
  • 4-BROMO-TETRAHYDROPYRAN ISO 9001：2015 REACH
  • 25637-16-5
  • 75637-16-5
  • Organohalides
  • Pyran
  • Halides
  • Heterocycles