ChemicalBook > CAS DataBase List > Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride

Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride

Product Name
Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride
CAS No.
1021298-67-8
Chemical Name
Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride
Synonyms
1-(Cyclopropylcarbonyl)piperazine HCl;methanone hydrochloride;1-(cyclopropylcarbonyl)-, Monohydrochloride;(Cyclopropyl)(piperazin-1-yl)methanone hydrochloride;OlaparibIntermediate;1-(cyclopropylcarbonyl)-;Cyclopropyl(piperazin-1-yl);1-(CYCLOPROPANECARBONYL)PIPERAZINE HCl;Cyclopropionylpiperazine hydrochloride;CYCLOPROPYL(PIPERAZIN-1-YL)METHANONE HCL
CBNumber
CB02640147
Molecular Formula
C8H15ClN2O
Formula Weight
190.67
MOL File
1021298-67-8.mol
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Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride Property

Melting point:
175-179℃
storage temp. 
Inert atmosphere,Room Temperature
Water Solubility 
Soluble in water
form 
powder to crystal
color 
White to Orange to Green
InChI
InChI=1S/C8H14N2O.ClH/c11-8(7-1-2-7)10-5-3-9-4-6-10;/h7,9H,1-6H2;1H
InChIKey
WIHDAPMHNYYTOA-UHFFFAOYSA-N
SMILES
C(N1CCNCC1)(C1CC1)=O.Cl
CAS DataBase Reference
1021298-67-8
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3112
Product name
1-(Cyclopropylcarbonyl)piperazine Hydrochloride
Purity
>98.0%(T)
Packaging
1g
Price
$58
Updated
2025/07/31
TCI Chemical
Product number
C3112
Product name
1-(Cyclopropylcarbonyl)piperazine Hydrochloride
Purity
>98.0%(T)
Packaging
5g
Price
$233
Updated
2025/07/31
TRC
Product number
C986652
Product name
1-(Cyclopropylcarbonyl)piperazine Hydrochloride
Packaging
100mg
Price
$45
Updated
2021/12/16
Chem-Impex
Product number
43372
Product name
1-(Cyclopropylcarbonyl)piperazinehydrochloride,≥98%(Assaybytitration)
Purity
≥98%(Assaybytitration)
Packaging
1G
Price
$65.86
Updated
2021/12/16
Matrix Scientific
Product number
048745
Product name
1-(Cyclopropylcarbonyl)piperazine hydrochloride
Packaging
1g
Price
$95
Updated
2021/12/16
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Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride Chemical Properties,Usage,Production

Uses

1-(Cyclopropylcarbonyl)piperazine Hydrochloride is a reagent used in the synthesis of Esaprazole analogs showing σ1 binding and neuroprotective properties in vitro.

Synthesis

414910-15-9

1021298-67-8

The general procedure for the synthesis of cyclopropyl (piperazin-1-yl)methanone hydrochloride from tert-butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate was as follows: to a stirring solution of tert-butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate (3.7 g, 14.5 mmol) in methanol (15 mL) was added slowly at 0 °C a hydrochloric acid/methanol solution (15 mL, 3M). After addition, the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to afford cyclopropyl (piperazin-1-yl)methanone hydrochloride (2.74 g, 100% yield) as an off-white solid. The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ 0.71-0.76 (m, 4H), 1.96-2.03 (m, 1H), 3.04-3.16 (m, 4H), 3.69-4.08 (m, 4H), 9.58 (s, 2H); LC-MS (ESI) m/z: 155 (M + 1)+.

References

[1] Patent: US2010/35883, 2010, A1. Location in patent: Page/Page column 56
[2] Patent: WO2011/130661, 2011, A1. Location in patent: Page/Page column 102-103

Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride Suppliers

Americas 1 China 236 Europe 1 India 3 Japan 1 United Kingdom 2 United States 10 Global 254
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
1-(Cyclopropylcarbonyl)piperazine Hydrochloride 1021298-67-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-28
Henan Aochuang Chemical Co.,Ltd.
Product
Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride 1021298-67-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29
Shaanxi Dideu New Materials Co. Ltd
Product
Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride 1021298-67-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2024-11-13

1021298-67-8, Piperazine, 1-(cyclopropylcarbonyl)-, MonohydrochlorideRelated Search:

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