ChemicalBook > CAS DataBase List > Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride

Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride

Product Name: Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride
CAS No.: 1021298-67-8
Chemical Name: Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride
Synonyms: 1-(Cyclopropylcarbonyl)piperazine HCl;methanone hydrochloride;1-(cyclopropylcarbonyl)-, Monohydrochloride;(Cyclopropyl)(piperazin-1-yl)methanone hydrochloride;OlaparibIntermediate;1-(cyclopropylcarbonyl)-;Cyclopropyl(piperazin-1-yl);1-(CYCLOPROPANECARBONYL)PIPERAZINE HCl;Cyclopropionylpiperazine hydrochloride;CYCLOPROPYL(PIPERAZIN-1-YL)METHANONE HCL
CBNumber: CB02640147
Molecular Formula: C8H15ClN2O
Formula Weight: 190.67
MOL File: 1021298-67-8.mol

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Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride Property

Melting point:: 175-179℃
storage temp.: Inert atmosphere,Room Temperature
Water Solubility: Soluble in water
form: powder to crystal
color: White to Orange to Green
InChI: InChI=1S/C8H14N2O.ClH/c11-8(7-1-2-7)10-5-3-9-4-6-10;/h7,9H,1-6H2;1H
InChIKey: WIHDAPMHNYYTOA-UHFFFAOYSA-N
SMILES: C(N1CCNCC1)(C1CC1)=O.Cl
CAS DataBase Reference: 1021298-67-8

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3112
Product name: 1-(Cyclopropylcarbonyl)piperazine Hydrochloride
Purity: >98.0%(T)
Packaging: 1g
Price: $58
Updated: 2025/07/31

TCI Chemical

Product number: C3112
Product name: 1-(Cyclopropylcarbonyl)piperazine Hydrochloride
Purity: >98.0%(T)
Packaging: 5g
Price: $233
Updated: 2025/07/31

TRC

Product number: C986652
Product name: 1-(Cyclopropylcarbonyl)piperazine Hydrochloride
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 048745
Product name: 1-(Cyclopropylcarbonyl)piperazine hydrochloride
Packaging: 1g
Price: $95
Updated: 2021/12/16

Chem-Impex

Product number: 43372
Product name: 1-(Cyclopropylcarbonyl)piperazinehydrochloride,≥98%(Assaybytitration)
Purity: ≥98%(Assaybytitration)
Packaging: 1G
Price: $65.86
Updated: 2021/12/16

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Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride Chemical Properties,Usage,Production

Uses

1-(Cyclopropylcarbonyl)piperazine Hydrochloride is a reagent used in the synthesis of Esaprazole analogs showing σ1 binding and neuroprotective properties in vitro.

Synthesis

414910-15-9

1021298-67-8

The general procedure for the synthesis of cyclopropyl (piperazin-1-yl)methanone hydrochloride from tert-butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate was as follows: to a stirring solution of tert-butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate (3.7 g, 14.5 mmol) in methanol (15 mL) was added slowly at 0 °C a hydrochloric acid/methanol solution (15 mL, 3M). After addition, the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to afford cyclopropyl (piperazin-1-yl)methanone hydrochloride (2.74 g, 100% yield) as an off-white solid. The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ 0.71-0.76 (m, 4H), 1.96-2.03 (m, 1H), 3.04-3.16 (m, 4H), 3.69-4.08 (m, 4H), 9.58 (s, 2H); LC-MS (ESI) m/z: 155 (M + 1)+.

References

[1] Patent: US2010/35883, 2010, A1. Location in patent: Page/Page column 56
[2] Patent: WO2011/130661, 2011, A1. Location in patent: Page/Page column 102-103

Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 1-(Cyclopropylcarbonyl)piperazine Hydrochloride 1021298-67-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

Henan Aochuang Chemical Co.,Ltd.

Product: Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride 1021298-67-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
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Release date: 2022-09-29

Shaanxi Dideu New Materials Co. Ltd

Product: Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride 1021298-67-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-13

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