PIPERAZINE DIHYDROCHLORIDE

ChemicalBook > CAS DataBase List > PIPERAZINE DIHYDROCHLORIDE

PIPERAZINE DIHYDROCHLORIDE

Product Name: PIPERAZINE DIHYDROCHLORIDE
CAS No.: 142-64-3
Chemical Name: PIPERAZINE DIHYDROCHLORIDE
Synonyms: dowzenedhc;Piperazine 2HCl;dihydropipwormer;PIPERAZINE DI HCL;piperazinewormerpremix;Piperazine hydrate CRS;piperazinehydrochloride;Piperazinium Dichloride;PIPERAZINE DIHYDROCHLORIDE;Olaparib Impurity 10 DiHCl
CBNumber: CB0264741
Molecular Formula: C4H12Cl2N2
Formula Weight: 159.06
MOL File: 142-64-3.mol

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PIPERAZINE DIHYDROCHLORIDE Property

Melting point:: 320°C(dec.)(lit.)
Boiling point:: 262.01°C (rough estimate)
Density: 1.3011 (rough estimate)
refractive index: 1.6300 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: Water
form: White crystalline solid
color: White to Off-White
InChI: InChI=1S/C4H10N2.2ClH/c1-2-6-4-3-5-1;;/h5-6H,1-4H2;2*1H
InChIKey: CVVIJWRCGSYCMB-UHFFFAOYSA-N
SMILES: C1NCCNC1.Cl.Cl
LogP: -1.171 (est)
CAS DataBase Reference: 142-64-3(CAS DataBase Reference)
EPA Substance Registry System: Piperazine dihydrochloride (142-64-3)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-42/43
Safety Statements: 22-26-36/37
OEB: B
OEL: TWA: 5 mg/m3
RTECS: TL4025000
F: 3-10
HS Code: 2933599550
Hazardous Substances Data: 142-64-3(Hazardous Substances Data)
Toxicity: mouse,LD50,intraperitoneal,1970mg/kg (1970mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION,Japanese Journal of Pharmacology. Vol. 17, Pg. 475, 1967.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P0450
Product name: Piperazine Dihydrochloride Monohydrate
Purity: >98.0%(N)
Packaging: 25g
Price: $33
Updated: 2024/03/01

TCI Chemical

Product number: P0450
Product name: Piperazine Dihydrochloride Monohydrate
Purity: >98.0%(N)
Packaging: 500g
Price: $162
Updated: 2024/03/01

TCI Chemical

Product number: P2491
Product name: Piperazine Dihydrochloride
Purity: >98.0%(N)(T)
Packaging: 1g
Price: $41
Updated: 2024/03/01

TCI Chemical

Product number: P2491
Product name: Piperazine Dihydrochloride
Purity: >98.0%(N)(T)
Packaging: 5g
Price: $107
Updated: 2024/03/01

TRC

Product number: P480100
Product name: Piperazine dihydrochloride
Packaging: 1g
Price: $120
Updated: 2021/12/16

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PIPERAZINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

It is used as a one day wormer, either in water or feed, for the control of Round worms in poultry, swine, and horses. It also controls nodular worms in swine, and small strongyles in horses.

Uses

In the manufacture of fibers, pharmarceuticals, and insecticides.

Uses

Piperazine Dihydrochloride is an anthelmintic agent used in the treatment of parasitic worms in animals.

General Description

White to cream-colored needles or powder. Mp: 318-20°C (with decomposition).

Reactivity Profile

PIPERAZINE DIHYDROCHLORIDE is incompatible with the following: Water, HEAT, flames, oxidizers. PIPERAZINE DIHYDROCHLORIDE absorbs moisture from air. PIPERAZINE DIHYDROCHLORIDE may create flammable condition upon contact with HEAT, FLAMES and OXIDIZERS.

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used in making fiber, pharmaceuticals, and insecticides. See also PIPERAZINE.

Potential Exposure

Agricultural chemical, Suspected reprotoxic hazard. Piperazine is used to manufacture anthelmintics, antifilarials, antihistamines, and tranquilizers; the dihydrochloride is used in the manufacture of fibers, pharmaceuticals and insecticides. They are used as an intermediate in the manufacture of, pesticides, rubber chemicals and fibers. Also, piperazine is widely available, effective, and safe when used on an occasional basis against ascaride infections. It is also considerably cheaper than other anthelminthic drugs. In some countries where ascariasis is not endemic and where piperazine was used predominantly for the treatment of pinworn, it has been withdrawn from use on the grounds that other effective drugs are now available. Clinical dosages occasionally induce transient neurological signs and, in some circumstances, the drug may generate small amounts of nitrosamine in the stomach, which at considerably greater dosage in experimental animals has been demonstrated to have a carcinogenic potential.

Carcinogenicity

Piperazine dihydrochloride is an irritant and sensitizer. Little information exists on the toxicology of piperazine dihydrochloride in humans or in animals. Acute human exposures to the dust have reportedly resulted in irritation to the eyes, mild to moderate skin burns, and sensitization. Exposure levels and duration were not available.

Purification Methods

Crystallise the salt from aqueous EtOH and dry it at 110o. [Beilstein 23 III/IV 17, 23/1 V 30.]

Incompatibilities

Aqueous solution is a strong base. Violent reaction with strong oxidizers and dicyanofurazan. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrogen compounds, carbon tetrachloride. Attacks aluminum, copper, nickel, magnesium and zinc.

PIPERAZINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

1-Methylpiperazine 1-(2-PYRIDIN-2-YL-ETHYL)-PIPERAZINE 2-(4-BENZYLPIPERAZINO)BENZALDEHYDE Piperazine 1-Hydroxyethylethoxypiperazine

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PIPERAZINE DIHYDROCHLORIDE Suppliers

Americas 1 Belgium 3 Canada 4 China 97 Czech Republic 2 Europe 3 France 1 Germany 6 India 31 Italy 1 Japan 4 Switzerland 1 The Netherlands 1 United Kingdom 7 United States 27 Global 189

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View Lastest Price from PIPERAZINE DIHYDROCHLORIDE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Piperazine (dihydrochloride) 142-64-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10000kg
Release date: 2024-11-09

Nanjing Deda New Material Technology Ltd.

Product: PIPERAZINE DIHYDROCHLORIDE 142-64-3
Price: US $10.00-30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100ton/ month
Release date: 2024-03-29

Henan Fengda Chemical Co., Ltd

Product: PIPERAZINE DIHYDROCHLORIDE 142-64-3
Price: US $50.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-22

142-64-3, PIPERAZINE DIHYDROCHLORIDERelated Search:

Diethyl azodicarboxylate 4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one 3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid 1,1,3,3-Tetramethylurea 1-Hydroxybenzotriazole Olaparib Impurity 14 5-Bromo-2-fluorobenzonitrile Cyclopropanecarbonyl Chloride 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile 2-Propanone, 1-[4,5-dihydro-2-(4-methyl-1-piperazinyl)-4-thioxo-3H-1,5-benzodiazepin-3-ylidene]- Olaparib Impurity 31 Olaparib Impurity 30 tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoyl)piperazine-1-carboxylate 2,2'-Oxybis(nitrobenzene) Olaparib Impurity 25 2,2'-OXYDIANILINE Olaparib Impurity 15 tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate

diethylenediaminedihydrochloride

dihydrochloridesaltofdiethylenediamine

dihydropipwormer

dowzenedhc

piperazinehydrochloride

piperazinewormerpremix

PIPERAZINE DIHYDROCHLORIDE

PIPERAZINE HYDROCHLORIDE HYDRATE

PIPERAZINE DI HCL

PiperidineHydrochloride>98%

Piperazine dihydrochloride (non-medicinal)

PIPERAZINEDIHYDROCHLORIDE,ULTRAPURE

Piperazine Dihydrochloride (200 mg)

Piperazine Dihydrochloride&nbsp

Piperazine, hydrochloride (1:2)

Piperazine-1,4-diium chloride

Olaparib Impurity 10 DiHCl

PiperazineDihydrochlorideMonohydrate&gt

Piperazine hydrate CRS

Piperazine dihydrochloride salt

Piperazinium Dichloride

PIPERAZINE DIHYDROCHLORIDE ISO 9001：2015 REACH

Piperazine Dihydrochloride (1541907)

Piperazine 2HCl

Trimetazidine EP Impurity G DiHCl

142-64-3

C4H10N22HClH2O

Building Blocks

Piperazines

Heterocyclic Building Blocks