ChemicalBook > CAS DataBase List > 4-Fluoro-2-methoxybenzonitrile

4-Fluoro-2-methoxybenzonitrile

Product Name: 4-Fluoro-2-methoxybenzonitrile
CAS No.: 191014-55-8
Chemical Name: 4-Fluoro-2-methoxybenzonitrile
Synonyms: BUTTPARK 80\07-22;4-Fluoro-o-anisonitrile;4-Fluoro-2-methoxybenzonitril;4-FLUORO-2-METHOXYBENZONITRILE;Benzonitrile, 4-fluoro-2-methoxy-;Benzonitrile, 4-fluoro-2-methoxy- (9CI);4-Fluoro-o-anisonitrile, 2-Cyano-5-fluoroanisole
CBNumber: CB0298137
Molecular Formula: C8H6FNO
Formula Weight: 151.14
MOL File: 191014-55-8.mol

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4-Fluoro-2-methoxybenzonitrile Property

Melting point:: 75 °C
Boiling point:: 239.2±20.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: crystalline solid
color: White to off-white
CAS DataBase Reference: 191014-55-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 23-36/37/39
RIDADR: 3276
Hazard Note: Irritant
HazardClass: 6.1
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: F599358
Product name: 4-Fluoro-2-methoxybenzonitrile
Packaging: 500mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3637-3-X1
Product name: 4-Fluoro-2-methoxybenzonitrile
Packaging: 25g
Price: $232
Updated: 2021/12/16

AK Scientific

Product number: X2776
Product name: 4-Fluoro-2-methoxybenzonitrile
Packaging: 25g
Price: $237
Updated: 2021/12/16

Matrix Scientific

Product number: 131684
Product name: 4-Fluoro-2-methoxybenzonitrile
Purity: 97%
Packaging: 25g
Price: $468
Updated: 2021/12/16

AK Scientific

Product number: X2776
Product name: 4-Fluoro-2-methoxybenzonitrile
Packaging: 100g
Price: $571
Updated: 2021/12/16

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4-Fluoro-2-methoxybenzonitrile Chemical Properties,Usage,Production

Chemical Properties

off-white crytalline

Synthesis

450-88-4

544-92-3

191014-55-8

General procedure for the synthesis of 2-methoxy-4-fluorobenzonitrile from 2-bromo-5-fluoroanisole and cuprous cyanide: to a solution of N-methylpyrrolidone (100 mL, Sure Seal; Aldrich) containing 1-bromo-4-fluoro-2-methoxybenzene (9.0 g) was added cuprous cyanide (6.6 g, 73.7 mmol, 1.8 equiv. Aldrich). The reaction mixture was stirred at 180 °C for 5.5 h in an anhydrous nitrogen atmosphere. After completion of the reaction, it was cooled to room temperature, a 14% aqueous ammonia solution (330 mL) was added, and stirring was continued at room temperature for 45 min. The reaction mixture was extracted with ether (100 mL x 3), and the organic phases were combined, washed sequentially with dilute ammonia, dilute hydrochloric acid and brine, and then dried with anhydrous magnesium sulfate, and concentrated to give 2-methoxy-4-fluorobenzonitrile (5.2 g, 85% yield in two steps). The product was a white solid with the following 1H NMR (CDCl3,500MHz) data: δ 3.91 (3H, s, OMe), 6.69 (1H, dd, J = 2.3Hz, J = 10.5Hz, Ar-H), 6.72 (1H, dt, J = 2.5Hz, J = 8.0Hz, Ar-H), 7.55 (1H, dd, J = 6.5 Hz, J = 8.5 Hz, Ar-H); 13C NMR (CDCl3,125.8 Hz) data as follows: δ 56.49, 98.16, 100.06, 100.27, 108.31, 108.50, 115.83, 135.37, 135.46, 163.25, 163.34, 165.47, 167.50. 167.50. analytical samples were obtained by ether milling. Calculated values for elemental analysis (C8H6FNO): C, 63.57; H, 4.00; N, 9.26; measured values: C, 63.36; H, 3.91; N, 9.16.

References

[1] Patent: US2005/267105, 2005, A1. Location in patent: Page/Page column 67
[2] Patent: EP1510516, 2005, A1. Location in patent: Page/Page column 88
[3] Patent: US2007/111984, 2007, A1. Location in patent: Page/Page column 32-33
[4] Patent: US2007/129379, 2007, A1. Location in patent: Page/Page column 26
[5] Patent: WO2007/64316, 2007, A1. Location in patent: Page/Page column 152

4-Fluoro-2-methoxybenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Fluoro-2-methoxybenzonitrile manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Fluoro-2-methoxybenzonitrile 191014-55-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-06

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Fluoro-2-methoxybenzonitrile 191014-55-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2025-03-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Fluoro-2-methoxybenzonitrile 191014-55-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

191014-55-8, 4-Fluoro-2-methoxybenzonitrileRelated Search:

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4-FLUORO-2-METHOXYBENZONITRILE

BUTTPARK 80\07-22

4-Fluoro-2-methoxybenzonitril

Benzonitrile, 4-fluoro-2-methoxy- (9CI)

4-Fluoro-o-anisonitrile, 2-Cyano-5-fluoroanisole

Benzonitrile, 4-fluoro-2-methoxy-

4-Fluoro-o-anisonitrile

191014-55-8

Fluorine series

Anisoles, Alkyloxy Compounds & Phenylacetates

Fluorine Compounds

Nitriles

HALIDE

Aromatic Nitriles