4-Fluoro-2-methoxybenzonitrile
- Product Name
- 4-Fluoro-2-methoxybenzonitrile
- CAS No.
- 191014-55-8
- Chemical Name
- 4-Fluoro-2-methoxybenzonitrile
- Synonyms
- BUTTPARK 80\07-22;4-Fluoro-o-anisonitrile;4-Fluoro-2-methoxybenzonitril;4-FLUORO-2-METHOXYBENZONITRILE;Benzonitrile, 4-fluoro-2-methoxy-;Benzonitrile, 4-fluoro-2-methoxy- (9CI);4-Fluoro-o-anisonitrile, 2-Cyano-5-fluoroanisole
- CBNumber
- CB0298137
- Molecular Formula
- C8H6FNO
- Formula Weight
- 151.14
- MOL File
- 191014-55-8.mol
4-Fluoro-2-methoxybenzonitrile Property
- Melting point:
- 75 °C
- Boiling point:
- 239.2±20.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- crystalline solid
- color
- White to off-white
- CAS DataBase Reference
- 191014-55-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 23-36/37/39
- RIDADR
- 3276
- Hazard Note
- Irritant
- HazardClass
- 6.1
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F599358
- Product name
- 4-Fluoro-2-methoxybenzonitrile
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 3637-3-X1
- Product name
- 4-Fluoro-2-methoxybenzonitrile
- Packaging
- 25g
- Price
- $232
- Updated
- 2021/12/16
- Product number
- X2776
- Product name
- 4-Fluoro-2-methoxybenzonitrile
- Packaging
- 25g
- Price
- $237
- Updated
- 2021/12/16
- Product number
- 131684
- Product name
- 4-Fluoro-2-methoxybenzonitrile
- Purity
- 97%
- Packaging
- 25g
- Price
- $468
- Updated
- 2021/12/16
- Product number
- X2776
- Product name
- 4-Fluoro-2-methoxybenzonitrile
- Packaging
- 100g
- Price
- $571
- Updated
- 2021/12/16
4-Fluoro-2-methoxybenzonitrile Chemical Properties,Usage,Production
Chemical Properties
off-white crytalline
Synthesis
450-88-4
544-92-3
191014-55-8
General procedure for the synthesis of 2-methoxy-4-fluorobenzonitrile from 2-bromo-5-fluoroanisole and cuprous cyanide: to a solution of N-methylpyrrolidone (100 mL, Sure Seal; Aldrich) containing 1-bromo-4-fluoro-2-methoxybenzene (9.0 g) was added cuprous cyanide (6.6 g, 73.7 mmol, 1.8 equiv. Aldrich). The reaction mixture was stirred at 180 °C for 5.5 h in an anhydrous nitrogen atmosphere. After completion of the reaction, it was cooled to room temperature, a 14% aqueous ammonia solution (330 mL) was added, and stirring was continued at room temperature for 45 min. The reaction mixture was extracted with ether (100 mL x 3), and the organic phases were combined, washed sequentially with dilute ammonia, dilute hydrochloric acid and brine, and then dried with anhydrous magnesium sulfate, and concentrated to give 2-methoxy-4-fluorobenzonitrile (5.2 g, 85% yield in two steps). The product was a white solid with the following 1H NMR (CDCl3,500MHz) data: δ 3.91 (3H, s, OMe), 6.69 (1H, dd, J = 2.3Hz, J = 10.5Hz, Ar-H), 6.72 (1H, dt, J = 2.5Hz, J = 8.0Hz, Ar-H), 7.55 (1H, dd, J = 6.5 Hz, J = 8.5 Hz, Ar-H); 13C NMR (CDCl3,125.8 Hz) data as follows: δ 56.49, 98.16, 100.06, 100.27, 108.31, 108.50, 115.83, 135.37, 135.46, 163.25, 163.34, 165.47, 167.50. 167.50. analytical samples were obtained by ether milling. Calculated values for elemental analysis (C8H6FNO): C, 63.57; H, 4.00; N, 9.26; measured values: C, 63.36; H, 3.91; N, 9.16.
References
[1] Patent: US2005/267105, 2005, A1. Location in patent: Page/Page column 67
[2] Patent: EP1510516, 2005, A1. Location in patent: Page/Page column 88
[3] Patent: US2007/111984, 2007, A1. Location in patent: Page/Page column 32-33
[4] Patent: US2007/129379, 2007, A1. Location in patent: Page/Page column 26
[5] Patent: WO2007/64316, 2007, A1. Location in patent: Page/Page column 152
4-Fluoro-2-methoxybenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluoro-2-methoxybenzonitrile manufacturers
- Product
- 4-Fluoro-2-methoxybenzonitrile 191014-55-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-06
- Product
- 4-Fluoro-2-methoxybenzonitrile 191014-55-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2025-03-14
- Product
- 4-Fluoro-2-methoxybenzonitrile 191014-55-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11