ChemicalBook > CAS DataBase List > 1,3,5-Trimethoxybenzene

1,3,5-Trimethoxybenzene

Product Name
1,3,5-Trimethoxybenzene
CAS No.
621-23-8
Chemical Name
1,3,5-Trimethoxybenzene
Synonyms
Benzene, 1,3,5-trimethoxy-;1,3,5-Trimethyoxybenzene;PHLOROGLUCINOL TRIMETHYL ETHER;1,3,5-Methoxybenzene;2,4,6-Trimethoxybenzene;1,3,5-Trimethoxybenzene Vetec(TM) reagent grade, 98%;Phloroglucinol trimethyl ether, 3,5-Dimethoxyanisole;1,3,5-TriMetho;TRISMETHOXYBENZENE;5-TriMethoxybenzene
CBNumber
CB0371005
Molecular Formula
C9H12O3
Formula Weight
168.19
MOL File
621-23-8.mol
More
Less

1,3,5-Trimethoxybenzene Property

Melting point:
50-53 °C (lit.)
Boiling point:
255 °C (lit.)
Density 
1,126g/cm
refractive index 
1,533
Flash point:
186 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
methanol: 0.1 g/mL, clear, colorless
form 
Crystalline Powder
color 
White to cream
Water Solubility 
insoluble
BRN 
1307993
InChIKey
LKUDPHPHKOZXCD-UHFFFAOYSA-N
LogP
1.605 (est)
CAS DataBase Reference
621-23-8(CAS DataBase Reference)
NIST Chemistry Reference
1,3,5-Trimethoxybenzene(621-23-8)
EPA Substance Registry System
1,3,5-Trimethoxybenzene (621-23-8)
More
Less

Safety

Hazard Codes 
Xn,F
Risk Statements 
22-20/21/22
Safety Statements 
24/25-36-26
RIDADR 
1325
WGK Germany 
3
RTECS 
DC2810000
Hazard Note 
Flammable Solid/Harmful
TSCA 
Yes
HazardClass 
4.1
PackingGroup 
III
HS Code 
29093090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
138827
Product name
1,3,5-Trimethoxybenzene
Purity
ReagentPlus , ≥99%
Packaging
10g
Price
$37.1
Updated
2025/07/31
Sigma-Aldrich
Product number
138827
Product name
1,3,5-Trimethoxybenzene
Purity
ReagentPlus , ≥99%
Packaging
50g
Price
$113
Updated
2025/07/31
TCI Chemical
Product number
P0250
Product name
1,3,5-Trimethoxybenzene
Purity
>98.0%(GC)
Packaging
25g
Price
$42
Updated
2025/07/31
TCI Chemical
Product number
P0250
Product name
1,3,5-Trimethoxybenzene
Purity
>98.0%(GC)
Packaging
100g
Price
$125
Updated
2025/07/31
Sigma-Aldrich
Product number
74599
Product name
1,3,5-Trimethoxybenzene
Purity
Standard for quantitative NMR, TraceCERT
Packaging
1g
Price
$181
Updated
2025/07/31
More
Less

1,3,5-Trimethoxybenzene Chemical Properties,Usage,Production

Chemical Properties

white to cream crystalline powder. Insoluble in water.

Uses

1,3,5-Trimethoxybenzene is a major scent component of the Chinese rose odour. 1,3,5-Trimethoxybenzene is also a useful synthetic intermediate and is used to synthesize triaryl- and triheteroarylmethanes.

Definition

ChEBI: 1,3,5-trimethoxybenzene is a methoxybenzene carrying methoxy groups at positions 1, 3 and 5. It has been found to be a biomarker of flavonoid consumption in humans. It has a role as a biomarker and a human xenobiotic metabolite.

Reactions

1,3,5-Trimethoxybenzene is the main component of the Leaf Oil of Eugenia confusa and is also a commonly used chemical reagent in organic synthesis. It can be used in the following reactions:
(1) Friedel–Crafts reaction: In this reaction, 4,5-dichlorocyclopent-4-ene-1,3-dione reacts with 1,3,5-trimethoxybenzene to synthesize 5-(2,4,6-trimethoxyphenyl)-4-chlorocyclopent-4-ene-1,3-dione, and also generates the disubstituted product 3,4-bis-(2,4,6-trimethoxyphenyl)-2-chlorocyclopent-2-ene-1-one[1].
(2) Addition reaction: Using trifluoromethanesulfonic acid as a catalyst, 1,3,5-trimethoxybenzene can react with maleimide to undergo a 1,4-addition reaction to synthesize 3-(2,4,6-trimethoxyphenyl) succinimide. It can also undergo a 1,4-addition reaction with acrylates[2].
(3) Nitration reaction: 1,3,5-Trimethoxybenzene can be nitrated with N2O5 in an organic solvent to prepare 1,3,5-trimethoxy-2,4,6-trinitrobenzene. However, this method is not very practical due to the side reactions of oxidation and coupling[3].

General Description

1,3,5-Trimethoxybenzene effectively cleaves p-methoxybenzyl protecting group on various alcohols and acids. It is the major scent compound present in Chinese rose species.

Synthesis

A solution of anhydrous phloroglucinol (6.3 g，0.05 mole) in dryacetone (100 ml) is refluxed for 6 hr under anhydrous conditions withdimethyl sulphate (15. 6 ml，20.8 g, 0.165 mole) in presence of ignitedpotassium carbonate (40 g).The mixture is filtered, and the inorganic saltswashed with hot acetone (2 × 20 ml). The combined acetone solution isdistilled and the residue macerated with crushed ice. It is extracted withether, the ether extracts washed with sodium hydroxide solution (5%),water，dried (sodium sulphate) and distilled. Yield 1,3,5-Trimethoxybenzene 6 g (71.4 %).M.p 52-3° (lit. m.p.52-53°).

Solubility in organics

Soluble in Methanol, Ether, Ethanol, Benzene.

Solubility in water

Insoluble

Purification Methods

Sublime it under vacuum. [Beilstein 6 III 635, 6 IV 7362.]

References

[1] V. A. EGOROV. Double Acylation Product in the SnCl4-promoted Reaction of 4,5-Dichlorocyclopent-4-en-1,3-dione with 1,3,5-Trimethoxybenzene[J]. Russian Journal of Organic Chemistry, 2023, 59 8: 1449-1452. DOI:10.1134/S1070428023080201.
[2] SEANGHAI HOR . Br?nsted acid-catalyzed 1,4-addition of 1,3,5-trimethoxybenzene to maleimides and acrylates[J]. Tetrahedron Letters, 2021, 74: Article 153100. DOI:10.1016/j.tetlet.2021.153100.
[3] A. J. BELLAMY. Nitration of 1,3,5-Trimethoxybenzene[J]. Journal of Chemical Research-s, 2002, 109 3 1: 412-413. DOI:10.3184/030823402103172662.

1,3,5-Trimethoxybenzene Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1,3,5-Trimethoxybenzene Suppliers

Americas 1 Belgium 3 Canada 4 China 485 Europe 3 France 3 Germany 10 India 28 Japan 5 Slovakia 1 South Korea 3 Switzerland 4 Ukraine 2 United Kingdom 18 United States 53 USA 1 Global 624
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
Alfa Chemistry
Tel
+1-5166625404;
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
20405
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Redox Scientific
Tel
--
Fax
--
Email
info@redoxsci.com
Country
United States
ProdList
2380
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
Lab Express International
Tel
--
Fax
--
Email
@labexpress.com
Country
United States
ProdList
307
Advantage
58
Penta Manufacturing Company (a division of Penta International Corporation)
Tel
--
Fax
--
Email
@pentamfg.com
Country
United States
ProdList
901
Advantage
58
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
Penta International Corporation
Tel
--
Fax
--
Email
lisaa@pentamfg.com
Country
United States
ProdList
5042
Advantage
58
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Penta Manufacturing Company
Tel
--
Fax
--
Email
sales@pentamfg.com
Country
United States
ProdList
5076
Advantage
65
Parish Chemical Company
Tel
--
Fax
--
Country
United States
ProdList
1248
Advantage
47
Sinova Inc.
Tel
--
Fax
--
Email
sales@sinovainc.com
Country
United States
ProdList
4009
Advantage
58
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Pharnorcia Inc. US
Tel
--
Fax
--
Email
info@pharnorcia.com
Country
United States
ProdList
112
Advantage
34
NetQem
Tel
--
Fax
--
Email
sales@netqem.us
Country
United States
ProdList
1641
Advantage
38
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Aagile Labs Division of Tyger Scientific
Tel
--
Fax
--
Email
tygersci@yahoo.com
Country
United States
ProdList
6568
Advantage
68
TimTec Corporation
Tel
--
Fax
--
Country
United States
ProdList
1945
Advantage
58
Sisco Research Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
srlmarketing@dishnetdsl.net
Country
United States
ProdList
1905
Advantage
64
Dishman Europe Ltd
Tel
--
Fax
--
Email
info@dishman-europe.com
Country
United States
ProdList
622
Advantage
58
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
Davos Chemical Corporation
Tel
--
Fax
--
Email
info@davos.com
Country
United States
ProdList
1640
Advantage
65
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
ChemSampCo, Inc.
Tel
--
Fax
--
Email
sales@chemsampco.com
Country
United States
ProdList
3585
Advantage
60
DSM Fine Chemicals Inc.
Tel
--
Fax
--
Country
United States
ProdList
151
Advantage
46
Eastern Chemical Corp.
Tel
--
Fax
--
Email
eastern@u-g.com
Country
United States
ProdList
2786
Advantage
34
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
AB Chem Technologies, LLC
Tel
--
Fax
--
Email
sales@abchemtech.com
Country
United States
ProdList
1101
Advantage
46
More
Less

View Lastest Price from 1,3,5-Trimethoxybenzene manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
1,3,5-Trimethoxybenzene 621-23-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 TON
Release date
2024-11-01
Hebei Chuanghai Biotechnology Co., Ltd
Product
1,3,5-Trimethoxybenzene 621-23-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-04
Henan Aochuang Chemical Co.,Ltd.
Product
1,3,5-Trimethoxybenzene 621-23-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29

621-23-8, 1,3,5-TrimethoxybenzeneRelated Search:

Anisole Ethylbenzene PETROLEUM ETHER o-Anisaldehyde Trimethyl phosphite 3,4,5-Trimethoxyphenol (3-Methoxyphenyl)acetonitrile 4-Methoxyphenylacetic acid 2-Butoxyethanol m-Anisyl alcohol (Trifluoromethoxy)benzene Phloroglucinol p-Anisaldehyde 3-(METHOXYMETHOXY)BENZALDEHYDE Trimethyl borate 3,4,5-Trimethoxy benzoic acid Dimethyl ether Trimethylphloroglucinol

  • 1,3,5-Trimethoxybenzene Vetec(TM) reagent grade, 98%
  • PHLOROGLUCINOL TRIMETHYL ETHER
  • TRISMETHOXYBENZENE
  • 1,3,5-TriMethoxybenzene ReagentPlus(R), >=99%
  • 1,3,5-Methoxybenzene
  • 1,3,5-TriMetho
  • 1,3,5-trimethoxy-benzen
  • 1,3,5-Trimethyoxybenzene
  • Benzene, 1,3,5-trimethoxy-
  • 3,5-DIMETHOXYANISOLE
  • 1,3,5-TRIMETHOXYBENZENE
  • 1,3,5-Trimethoxybenzene/Phloroglucinol trimethyl ether
  • O,O,O-1,3,5-trimethylresorcinol
  • 1,3,5-TRIMETHOXYBENZENE, 99+%
  • 1,3,5-TrimethoxybenzeneC9H12O3
  • 1,3,5-TRIMETHOXYBENZENE pure
  • 1,3,5-Trimethoxybenzene (TMB)
  • 1,3,5-Trimethoxybenz
  • 5-TriMethoxybenzene
  • Phloroglucinol trimethyl ether, 3,5-Dimethoxyanisole
  • 1,3,5-TriMethoxybenzene, 99% 10GR
  • sym-Trimethoxybenzene
  • 2,4,6-Trimethoxybenzene
  • 1,3,5-Trimethoxybenzene&gt
  • 1,3,5-Trimethoxybenzene Standard
  • O,O,O-1,3,5-Trimethylresorcin
  • 1,3,5-Trimethoxybenzene ISO 9001：2015 REACH
  • Trimethy phloroglucinol
  • 1,3,5-Trimethoxybenzene, 10 mM in DMSO
  • 1,3,5-Trimethoxybenzene, 98%
  • l,3,5-Trimethoxy-Benzene
  • 621-23-8
  • 621-23-08
  • 621-2308
  • C9H12O3
  • Organic Building Blocks
  • Building Blocks
  • Oxygen Compounds
  • Ethers
  • Benzene derivates
  • Aromatic Ethers
  • ACTIVE PHARMACEUTICAL INGREDIENTS
  • 621-23-8
  • API