ChemicalBook > CAS DataBase List > trans-1,2-Cyclohexanedicarboxylic acid

trans-1,2-Cyclohexanedicarboxylic acid

Product Name
trans-1,2-Cyclohexanedicarboxylic acid
CAS No.
2305-32-0
Chemical Name
trans-1,2-Cyclohexanedicarboxylic acid
Synonyms
TRANS-HEXAHYDRO-PHTHALIC ACID;TRANS-CYCLOHEXANE-1,2-DICARBOXYLIC ACID;trans-Cyclohexane-1,2-dicarboxylic acid, trans-Hexahydrophthalic acid;Lura;trans-CycL;REMAINDER CIS;RSYY（Avanafil)-15;ohexane-1,2-dicarboxyL;Lurasidone InterMediate(1);1,2-cyclohexanedicarboxylic
CBNumber
CB0376262
Molecular Formula
C8H12O4
Formula Weight
172.18
MOL File
2305-32-0.mol
More
Less

trans-1,2-Cyclohexanedicarboxylic acid Property

Melting point:
228-230 °C (lit.)
Boiling point:
262.49°C (rough estimate)
Density 
1.2104 (rough estimate)
refractive index 
1.4450 (estimate)
storage temp. 
Store below +30°C.
solubility 
Acetone (Slightly), DMSO (Slightly)
form 
Solid
pka
pK1:4.18;pK2: 5.93 (20°C)
color 
White
Water Solubility 
2g/L(20 ºC)
BRN 
3200609
InChIKey
QSAWQNUELGIYBC-WDSKDSINSA-N
CAS DataBase Reference
2305-32-0(CAS DataBase Reference)
NIST Chemistry Reference
1,2-Cyclohexanedicarboxylic acid, trans-(2305-32-0)
EPA Substance Registry System
1,2-Cyclohexanedicarboxylic acid, (1R,2R)-rel- (2305-32-0)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
GU9065000
TSCA 
Yes
HS Code 
29172000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.41088
Product name
trans-Cyclohexane-1,2-dicarboxylic acid
Purity
for synthesis
Packaging
5G
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
147516
Product name
trans-1,2-Cyclohexanedicarboxylic acid
Purity
95%
Packaging
25g
Price
$311
Updated
2023/01/07
TCI Chemical
Product number
C0474
Product name
trans-1,2-Cyclohexanedicarboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$129
Updated
2024/03/01
TCI Chemical
Product number
C0474
Product name
trans-1,2-Cyclohexanedicarboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
500g
Price
$1217
Updated
2024/03/01
Alfa Aesar
Product number
L11288
Product name
trans-1,2-Cyclohexanedicarboxylic acid
Purity
98%
Packaging
5g
Price
$56.65
Updated
2024/03/01
More
Less

trans-1,2-Cyclohexanedicarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

trans-1,2-cyclohexanedicarboxylic acid be used as organic intermediates.

Uses

trans-1,2-Cyclohexanedicarboxylic Acid is used as a reagent in the synthesis of enantiopure (α-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and its analogs as selective cathepsin K inhibitors for the treatment of osteoarthritis. Also used as a reagent in the synthesis of novel cyclopentanedicarboxamide sodium channel blockers as a potential treatment for chronic pain.

Purification Methods

It is purified by recrystallisation from EtOH or H2O. It is formed by hydrolyzing the anhydride with water. The dimethyl ester has m 95-96o (from *C6H6/pet ether). [Abell J Org Chem 22 769 1957, Smith & Byrne J Am Chem Soc 72 4406 1950, Linstead et al. J Am Chem Soc 64 2093 1942, Beilstein 9 III 3812, 9 IV 2801.] The 1R,2R-(-)-trans-cyclohexane-1,2-acid [46022-05-3] has m 171-182o and [ ] D -20o (c 1, Me2CO). cis-Cyclohexane-1,2-dicarboxylic anhydride (cis-hexahydrophthalic anhydride) [85-42-7, 13149-00-3] M 154.2, m 32-34o, b 158o/17mm. It has been obtained by heating the trans-acid or anhydride at 200o. Crystallise it from *C6H6/Et2O or distil it. [Kohler & Jansen J Am Chem Soc 60 2145 1938, Abell J Org Chem 22 769 1957, Beilstein 17 II 452, 17 III/IV 5931.]

trans-1,2-Cyclohexanedicarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

trans-1,2-Cyclohexanedicarboxylic acid Suppliers

Americas 1 Belgium 2 China 242 Europe 1 Germany 7 India 11 Japan 2 Norway 1 South Korea 1 Switzerland 1 United Kingdom 9 United States 26 Global 304
Loudi Xinjiyuan Chemistry Co., Ltd.
Tel
0738-8280700 18073853168
Email
1613791657@qq.com
Country
China
ProdList
19
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12443
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9510
Advantage
66
Suzhou Zehou Biotechnology Co. , Ltd.
Tel
0512-68716880 19984816880
Fax
18075373931
Email
sales@growingchem.com
Country
China
ProdList
194
Advantage
64
Shanghai Boc Chemical Co.,Ltd
Tel
021-34975603-808 18721111801
Fax
+86-21-34975602-805
Email
sales@bocpharma.com
Country
China
ProdList
998
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9810
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8835
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4001
Advantage
55
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18021050169
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Qingdao Kingway Pharmtech Co., Ltd.
Tel
0532-87118899
Fax
0532-84117788
Email
sales@kingwaypharm.com
Country
China
ProdList
119
Advantage
56
Wuxi Zhangkun Biochemical Technology Co., Ltd.
Tel
+86 0510-85629785
Fax
+86 0510-85625359
Country
China
ProdList
2327
Advantage
58
Shanghai Huikai Chemical Technology Co., Ltd.
Tel
021-61995394 18916691159
Email
chemicalsea@163.com
Country
China
ProdList
1972
Advantage
58
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3930
Advantage
58
Beijing Universal Century Technology Co., Ltd.
Tel
400-8706899
Fax
400-8706899
Email
hysj_bj.com
Country
China
ProdList
3583
Advantage
55
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3120
Advantage
55
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4526
Advantage
56
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Chengdu Firster Pharmaceutical Co., Ltd.
Tel
028-87078428 028-87074958
Fax
8772-8116
Email
chengzhenyong@cdfirster.com
Country
China
ProdList
2677
Advantage
60
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Shanghai CanSpecsci Instrument Co., Ltd.
Tel
400-6087598 15021221957
Fax
4006087598-8012
Email
order@canspecsci.com
Country
China
ProdList
2045
Advantage
56
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4943
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10274
Advantage
55
Shanghai Na Qian Chemical Technology Co. Ltd.
Tel
0373-7129549; 13598610367
Fax
QQ:2468833170
Email
2841375912@qq.com
Country
China
ProdList
2727
Advantage
52
LUCKY PHARMA CO., LIMITED
Tel
0571-86403260 86403970
Fax
0571-86403970
Email
lucky@lkbiology.com
Country
China
ProdList
243
Advantage
58
Lanzhou HuaHao Pharmaceutical Co., Ltd.
Tel
18189674620
Email
761137152@qq.com
Country
China
ProdList
489
Advantage
55
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Giant chemicals
Tel
028-85434334 18108076537
Fax
QQ：245797092
Email
market@gianthx.com
Country
China
ProdList
4505
Advantage
56
Shanghai WeiNie Chemical Technology Co., Ltd.
Tel
15902145085
Fax
-
Email
657990292@qq.com
Country
China
ProdList
668
Advantage
50
More
Less

View Lastest Price from trans-1,2-Cyclohexanedicarboxylic acid manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
trans-1,2-Cyclohexanedicarboxylic acid 2305-32-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-30
Hebei Weibang Biotechnology Co., Ltd
Product
trans-1,2-Cyclohexanedicarboxylic acid 2305-32-0
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-06-15
Zhuozhou Wenxi import and Export Co., Ltd
Product
trans-1,2-Cyclohexanedicarboxylic acid 2305-32-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

2305-32-0, trans-1,2-Cyclohexanedicarboxylic acidRelated Search:

Potassium hydrogen phthalate Dimethyl phthalate CYCLOHEXANE-1,1-DICARBOXYLIC ACID Phthalic acid Bis(2-ethylhexyl) phthalate Isophthalic acid trans,trans-2,4-Undecadienal Cyclohexane (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione (1R,2R)-1,2-CYCLOHEXANEDIMETHANOL TRANS-CYCLOBUTANE-1,2-DICARBOXYLIC ACID Cyclobutane-1α,3β-dicarboxylic acid CIS/TRANS-1,4-CYCLOHEXANEDICARBOXYLIC ACID TRANS-1,4-CYCLOHEXANEDICARBOXYLIC ACID MONOMETHYL ESTER 1,2,3,4,5,6-Cyclohexanehexacarboxylic acid TRANS-1,4-CYCLOHEXANEDICARBOXYLIC ACID 1,2-CYCLOHEXANEDICARBOXYLIC ACID TRANS-2-CARBOMETHOXYCYCLOHEXANE-1-CARBOXYLIC ACID

  • trans-Cyclohexane-1,2-dicarboxylic acid for synthesis
  • TRANS-HEXAHYDRO-PHTHALIC ACID
  • TRANS-CYCLOHEXANE-1,2-DICARBOXYLIC ACID
  • TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACID
  • trans-Cyclohexane-1,2-dicarboxylic acid, trans-Hexahydrophthalic acid
  • TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACID, 95%, REMAINDER CIS
  • rel-(1R*)-1β*,2α*-Cyclohexanedicarboxylic acid
  • rel-(1R*,2R*)-1,2-Cyclohexanedicarboxylic acid
  • rel-Cyclohexane-1β*,2α*-dicarboxylic acid
  • trans-1,2-Cyclohexanedicarboxylic acid, remainder cis, 95%
  • TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACDI
  • Trans-1,2-cyclohexane carboxylic acid
  • 1,2-cyclohexanedicarboxylic
  • 1,2-Cyclohexanedicarboxylicacid, (1R,2R)-rel-
  • trans-1,2-Cyclohexanedicarboxylic acid ,98%
  • Lurasidone InterMediate(1)
  • Lura
  • REMAINDER CIS
  • trans-1,2-Cyclohexanedicarboxylic acid, reMainder cis TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACDI
  • <i>trans</i>-1,2-Cyclohexanedicarboxylic acid
  • trans-1,2-Cyclohexanedicarboxylic acid 95%
  • (1S,2S)-2-Carbamoyl-cyclohexanecarboxylic acid
  • trans-1,2-Cyclohexanedicarboxylic Acid &gt
  • ohexane-1,2-dicarboxyL
  • trans-CycL
  • rans-1,2-Cyclohexanedicarboxylicaci
  • Trans-1,2-Cyclohexanedicarboxylic acid(For export only)
  • Tans-1,2-Cyclohexanedicarboxylic acid
  • RSYY（Avanafil)-15
  • Trans racemic 1,2-cyclohexanedicarboxylic acid
  • Trans-1, 2-cyclohexandicarboxylic acid
  • 2305-32-0
  • CARBOXYLIC ACID
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts