ChemicalBook > CAS DataBase List > trans-1,2-Cyclohexanedicarboxylic acid

trans-1,2-Cyclohexanedicarboxylic acid

Product Name
trans-1,2-Cyclohexanedicarboxylic acid
CAS No.
2305-32-0
Chemical Name
trans-1,2-Cyclohexanedicarboxylic acid
Synonyms
TRANS-HEXAHYDRO-PHTHALIC ACID;TRANS-CYCLOHEXANE-1,2-DICARBOXYLIC ACID;trans-Cyclohexane-1,2-dicarboxylic acid, trans-Hexahydrophthalic acid;Lura;trans-CycL;REMAINDER CIS;RSYY（Avanafil)-15;ohexane-1,2-dicarboxyL;Lurasidone InterMediate(1);1,2-cyclohexanedicarboxylic
CBNumber
CB0376262
Molecular Formula
C8H12O4
Formula Weight
172.18
MOL File
2305-32-0.mol
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trans-1,2-Cyclohexanedicarboxylic acid Property

Melting point:
228-230 °C (lit.)
Boiling point:
262.49°C (rough estimate)
Density 
1.2104 (rough estimate)
refractive index 
1.4450 (estimate)
storage temp. 
Store below +30°C.
solubility 
Acetone (Slightly), DMSO (Slightly)
form 
Solid
pka
pK1:4.18;pK2: 5.93 (20°C)
color 
White
Water Solubility 
2g/L(20 ºC)
BRN 
3200609
InChIKey
QSAWQNUELGIYBC-WDSKDSINSA-N
CAS DataBase Reference
2305-32-0(CAS DataBase Reference)
NIST Chemistry Reference
1,2-Cyclohexanedicarboxylic acid, trans-(2305-32-0)
EPA Substance Registry System
1,2-Cyclohexanedicarboxylic acid, (1R,2R)-rel- (2305-32-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
GU9065000
TSCA 
Yes
HS Code 
29172000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.41088
Product name
trans-Cyclohexane-1,2-dicarboxylic acid
Purity
for synthesis
Packaging
5G
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
147516
Product name
trans-1,2-Cyclohexanedicarboxylic acid
Purity
95%
Packaging
25g
Price
$311
Updated
2023/01/07
TCI Chemical
Product number
C0474
Product name
trans-1,2-Cyclohexanedicarboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$129
Updated
2024/03/01
TCI Chemical
Product number
C0474
Product name
trans-1,2-Cyclohexanedicarboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
500g
Price
$1217
Updated
2024/03/01
Alfa Aesar
Product number
L11288
Product name
trans-1,2-Cyclohexanedicarboxylic acid
Purity
98%
Packaging
5g
Price
$56.65
Updated
2024/03/01
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trans-1,2-Cyclohexanedicarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

trans-1,2-cyclohexanedicarboxylic acid be used as organic intermediates.

Uses

trans-1,2-Cyclohexanedicarboxylic Acid is used as a reagent in the synthesis of enantiopure (α-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and its analogs as selective cathepsin K inhibitors for the treatment of osteoarthritis. Also used as a reagent in the synthesis of novel cyclopentanedicarboxamide sodium channel blockers as a potential treatment for chronic pain.

Purification Methods

It is purified by recrystallisation from EtOH or H2O. It is formed by hydrolyzing the anhydride with water. The dimethyl ester has m 95-96o (from *C6H6/pet ether). [Abell J Org Chem 22 769 1957, Smith & Byrne J Am Chem Soc 72 4406 1950, Linstead et al. J Am Chem Soc 64 2093 1942, Beilstein 9 III 3812, 9 IV 2801.] The 1R,2R-(-)-trans-cyclohexane-1,2-acid [46022-05-3] has m 171-182o and [ ] D -20o (c 1, Me2CO). cis-Cyclohexane-1,2-dicarboxylic anhydride (cis-hexahydrophthalic anhydride) [85-42-7, 13149-00-3] M 154.2, m 32-34o, b 158o/17mm. It has been obtained by heating the trans-acid or anhydride at 200o. Crystallise it from *C6H6/Et2O or distil it. [Kohler & Jansen J Am Chem Soc 60 2145 1938, Abell J Org Chem 22 769 1957, Beilstein 17 II 452, 17 III/IV 5931.]

trans-1,2-Cyclohexanedicarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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trans-1,2-Cyclohexanedicarboxylic acid Suppliers

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View Lastest Price from trans-1,2-Cyclohexanedicarboxylic acid manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
trans-1,2-Cyclohexanedicarboxylic acid 2305-32-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-30
Hebei Guanlang Biotechnology Co., Ltd.
Product
trans-1,2-Cyclohexanedicarboxylic acid 2305-32-0
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-06-15
Zhuozhou Wenxi import and Export Co., Ltd
Product
trans-1,2-Cyclohexanedicarboxylic acid 2305-32-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

2305-32-0, trans-1,2-Cyclohexanedicarboxylic acidRelated Search:

Potassium hydrogen phthalate Dimethyl phthalate CYCLOHEXANE-1,1-DICARBOXYLIC ACID Phthalic acid Bis(2-ethylhexyl) phthalate Isophthalic acid trans,trans-2,4-Undecadienal Cyclohexane (3aR,4S,7R,7aS) 4,7-Methano-1H-isoindole-1,3(2H)-dione (1R,2R)-1,2-CYCLOHEXANEDIMETHANOL TRANS-CYCLOBUTANE-1,2-DICARBOXYLIC ACID Cyclobutane-1α,3β-dicarboxylic acid CIS/TRANS-1,4-CYCLOHEXANEDICARBOXYLIC ACID TRANS-1,4-CYCLOHEXANEDICARBOXYLIC ACID MONOMETHYL ESTER 1,2,3,4,5,6-Cyclohexanehexacarboxylic acid TRANS-1,4-CYCLOHEXANEDICARBOXYLIC ACID 1,2-CYCLOHEXANEDICARBOXYLIC ACID TRANS-2-CARBOMETHOXYCYCLOHEXANE-1-CARBOXYLIC ACID

  • trans-Cyclohexane-1,2-dicarboxylic acid for synthesis
  • TRANS-HEXAHYDRO-PHTHALIC ACID
  • TRANS-CYCLOHEXANE-1,2-DICARBOXYLIC ACID
  • TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACID
  • trans-Cyclohexane-1,2-dicarboxylic acid, trans-Hexahydrophthalic acid
  • TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACID, 95%, REMAINDER CIS
  • rel-(1R*)-1β*,2α*-Cyclohexanedicarboxylic acid
  • rel-(1R*,2R*)-1,2-Cyclohexanedicarboxylic acid
  • rel-Cyclohexane-1β*,2α*-dicarboxylic acid
  • trans-1,2-Cyclohexanedicarboxylic acid, remainder cis, 95%
  • TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACDI
  • Trans-1,2-cyclohexane carboxylic acid
  • 1,2-cyclohexanedicarboxylic
  • 1,2-Cyclohexanedicarboxylicacid, (1R,2R)-rel-
  • trans-1,2-Cyclohexanedicarboxylic acid ,98%
  • Lurasidone InterMediate(1)
  • Lura
  • REMAINDER CIS
  • trans-1,2-Cyclohexanedicarboxylic acid, reMainder cis TRANS-1,2-CYCLOHEXANEDICARBOXYLIC ACDI
  • <i>trans</i>-1,2-Cyclohexanedicarboxylic acid
  • trans-1,2-Cyclohexanedicarboxylic acid 95%
  • (1S,2S)-2-Carbamoyl-cyclohexanecarboxylic acid
  • trans-1,2-Cyclohexanedicarboxylic Acid &gt
  • ohexane-1,2-dicarboxyL
  • trans-CycL
  • rans-1,2-Cyclohexanedicarboxylicaci
  • Trans-1,2-Cyclohexanedicarboxylic acid(For export only)
  • Tans-1,2-Cyclohexanedicarboxylic acid
  • RSYY（Avanafil)-15
  • 2305-32-0
  • CARBOXYLIC ACID
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts