Acetamidine hydrochloride

ChemicalBook > CAS DataBase List > Acetamidine hydrochloride

Acetamidine hydrochloride

Uses

Product Name: Acetamidine hydrochloride
CAS No.: 124-42-5
Chemical Name: Acetamidine hydrochloride
Synonyms: Acetamidine;ACETAMIDINE HCL;Acetoamidine hydrochloride;ETHANIMIDAMIDE HYDROCHLORIDE;ethanamidine;Acetamine HCl;Acetamidine hydrochl;ACETAMIDINIUM CHLORIDE;ACEDIAMINE HYDROCHLORIDE;Ethylamidinehydrochloride
CBNumber: CB0399289
Molecular Formula: C2H7ClN2
Formula Weight: 94.54
MOL File: 124-42-5.mol

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Acetamidine hydrochloride Property

Melting point:: 165-170 °C(lit.)
Boiling point:: 129.78°C (rough estimate)
Density: 1.0596 (rough estimate)
refractive index: 1.5500 (estimate)
storage temp.: Inert atmosphere,Room Temperature
pka: pK1: 1.60(+1) (25°C)
form: Crystalline Powder, Crystals and/or Chunks
color: White to cream
Water Solubility: 1 g/mL
Sensitive: Hygroscopic
Merck: 14,44
BRN: 3591762
InChIKey: WCQOBLXWLRDEQA-UHFFFAOYSA-N
CAS DataBase Reference: 124-42-5(CAS DataBase Reference)
EPA Substance Registry System: Ethanimidamide, monohydrochloride (124-42-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-36/38
Safety Statements: 26-37/39
WGK Germany: 3
F: 3
TSCA: Yes
HS Code: 29252000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 159158
Product name: Acetamidine hydrochloride
Purity: 95%
Packaging: 100g
Price: $84.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 159158
Product name: Acetamidine hydrochloride
Purity: 95%
Packaging: 500g
Price: $108.8
Updated: 2024/03/01

TCI Chemical

Product number: A0008
Product name: Acetamidine Hydrochloride
Purity: >95.0%(T)
Packaging: 25g
Price: $33
Updated: 2024/03/01

TCI Chemical

Product number: A0008
Product name: Acetamidine Hydrochloride
Purity: >95.0%(T)
Packaging: 500g
Price: $159
Updated: 2024/03/01

Alfa Aesar

Product number: A16091
Product name: Acetamidine hydrochloride, 97%
Packaging: 25g
Price: $26.65
Updated: 2024/03/01

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Acetamidine hydrochloride Chemical Properties,Usage,Production

Uses

Acetamidine Hydrochloride is a compound useful in organic synthesis.

Chemical Properties

WHITE FINE CRYSTALLINE POWDER

Uses

Acetamidine hydrochloride was used in the preparation of decarboxyectoine. It was also used in the synthesis of ethyl 4-(4-hydroxyphenyl)methylidene-2-methyl-5-oxo-1-imidazolacetate.

Application

Acetamidine hydrochloride can be used as an organic synthesis reactant for the preparation of other compounds such as 2-aminopyridine derivatives. Nucleophilic substitution and hydrolysis of 2-fluoropyridine and acetamidine hydrochloride can be used to synthesise 2-aminopyridine derivatives under catalyst-free conditions^[1]. This amination reaction has the advantages of high yield, high chemoselectivity and wide substrate adaptability using acetamidine hydrochloride as the ammonia source. In addition, an efficient heterogeneous copper-catalysed cascade reaction of aryl iodides with acetamidine hydrochloride produces primary amines^[2].

General Description

Acetamidine hydrochloride is an amidine salt and its conversion to 2,4,6-trimethyl-sym-triazine has been studied.

Purification Methods

The hydrochlorde can be recrystallised from small volumes of EtOH. Alternatively it is dissolved in EtOH, filtered, Et2O is added; filter the crystalline salt off under N2 and dry it in a vacuum desiccator over H2SO4. The salt is deliquescent and should be stored in a tightly stoppered container. Its solubility in H2O is 10% at room temperature and it is soluble in Me2CO. The free base reacts strongly alkaline in H2O. It has max 224nm ( 4000) in H2O. The picrate has m 252o (sintering at ~245o). [Dox Org Synth Coll Vol I 5 1941, Davies & Parsons Chem Ind (London) 628 1958, Barnes et al. J Am Chem Soc 62 1286 1940 give m 177-178o, Beilstein 2 H 185, 2 I 85, 2 II 183, 2 III 416, 2 IV 428.]

References

[1] YIBIAO LI . Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride1[J]. Organic & Biomolecular Chemistry, 2018, 16 41: Pages 7564-7567. DOI:10.1039/c8ob02129e.
[2] XUE HUANG. A highly efficient heterogeneous copper-catalysed cascade reaction of aryl iodides with acetamidine hydrochloride leading to primary arylamines[J]. Journal of Chemical Research-s, 2017, 46 1: 315-320. DOI:10.3184/174751917X14931195075580.

Acetamidine hydrochloride Preparation Products And Raw materials

Raw materials

ETHYL METHYL ETHER Acetonitrile Phosphoric acid Imine Chlorosulfonic acid Hydrogen chloride methanol solution Ammonium chloride Hydrochloric acid Methanol Ammonia

Preparation Products

5-Acetamidomethyl-4-Amino-2-Methyl pyrimidine 2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID Acetamiprid Thiamine nitrate 5-BROMO-4-HYDROXY-2-METHYLPYRIMIDINE 4-HYDROXY-2-METHYLPYRIMIDINE 4-AMINO-2-METHYLPYRIMIDINE-5-CARBONITRILE 4-(TRIFLUOROMETHYL)-2-METHYLPYRIMIDINE-5-CARBOXYLIC ACID Phosazetim 4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE 4-AMINO-2-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID 4-CHLORO-2-METHYLPYRIMIDINE 4(1H)-Pyrimidinone, 2-methyl- (8CI,9CI) 4,6-DIHYDROXY-2-METHYL-PYRIMIDINE-5-CARBALDEHYDE 4,6-Dihydroxy-2-methylpyrimidine Thiamine hydrochloride 4-HYDROXY-2-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER 4-HYDROXY-2-METHYL-6-TRIFLUOROMETHYLPYRIMIDINE

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View Lastest Price from Acetamidine hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Acetamidine hydrochloride 124-42-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2025-03-13

Hebei Mujin Biotechnology Co.,Ltd

Product: Acetamidine hydrochloride 124-42-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-18

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Acetamidine hydrochloride 124-42-5
Price: US $99.00-80.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-21

124-42-5, Acetamidine hydrochlorideRelated Search:

Benzamidine hydrochloride Eperisone hydrochloride Methoxyammonium chloride N-(1-Naphthyl)ethylenediamine dihydrochloride FORMAMIDINE HYDROCHLORIDE Phenformin hydrochloride Triethylamine hydrochloride A-AMINO-A-IMINOETHANE ACETATE Methylamine hydrochloride 2-Aminoethylammonium chloride Cysteamine hydrochloride Pyridine hydrochloride Ethylamine hydrochloride Trifluoroacetamidine Cyclopropane-1-carboximidamide hydrochloride D-Glucosamine hydrochloride Topotecan hydrochloride Butyramidine hydrochloride

ACETAMIDINIUM CHLORIDE

ACEDIAMINE HYDROCHLORIDE

Ethaneamidinehydrochloride

ethanimidamide,monohydrochloride

Ethylamidinehydrochloride

Acetalmidine hydrochioride

Acetamidine

ACECAMIDINE HYDROCHLORIDE

Acetamidine hydrochloride, 98+%

ETHANIMIDAMIDE HYDROCHLORIDE

ETHENYLAMIDINE HYDROCHLORIDE

ETHANAMIDINE HYDROCHLORIDE

A-AMINO-A-IMINOETHANE HYDROCHLORIDE

ACETAMIDINE HCL

ACETAMIDINE HYDROCHLORIDE

ethanamidine

Acetoamidine hydrochloride

Acetamidine hydrochloride,95%

Acetamidine hydrochloride ,97%

Acetamidine hydrochl

Methylamidine hydrochloride

Acetamine HCl

EthaniMidaMide, hydrochloride (1:1)

AcetaMidine hydrochloride, 98+% 100GR

AcetaMidine Hydrochloride , 95.0%(T)

AcetaMidine hydrochloride 95%

Acetamidine Hydrochloride &gt

Acetamidine hydrochloride 13C

Inorganic Chemicals, Inorganic Salts

124-42-5

C2H7CIN2

C2H6N2

C2H7ClN2

CH3CNHNH2HCl

CH3CNHNH2

C2H6N2HCl

C2H6N2ClH

Organic Building Blocks

Imines/Amidines

Nitrogen Compounds

Building Blocks

straight chain compounds

Miscellaneous Reagents

Fatty & Aliphatic Acids, Esters, Alcohols & Derivatives

pharmacetical

Aliphatics

Imines/Amidines

Nitrogen Compounds

Organic Building Blocks

Pharmaceutical Intermediates

124-42-5