3-Hydroxyazetidine hydrochloride

Product Name: 3-Hydroxyazetidine hydrochloride
CAS No.: 18621-18-6
Chemical Name: 3-Hydroxyazetidine hydrochloride
Synonyms: AZETIDIN-3-OL HYDROCHLORIDE;3-AZETIDINOL HYDROCHLORIDE;3-HYDROXYAZETIDINE HCL;Azetidin-3-ol hydrochloride, 3-Hydroxyazetane hydrochloride;AZETAN-2-ONE;BUTTPARK 75\04-67;Azetidine-3-ol.Hcl;Baricitinib-009-HCl;3-hydroxyazatidine HCl;3-Hydroxyl-azetidine HCl
CBNumber: CB0455455
Molecular Formula: C3H8ClNO
Formula Weight: 109.55
MOL File: 18621-18-6.mol

More

Less

3-Hydroxyazetidine hydrochloride Property

Melting point:: 85-90 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
Water Solubility: Soluble in water, DMSO, methanol.
Sensitive: Hygroscopic
Stability:: Hygroscopic
InChI: InChI=1S/C3H7NO.ClH/c5-3-1-4-2-3;/h3-5H,1-2H2;1H
InChIKey: UQUPQEUNHVVNKW-UHFFFAOYSA-N
SMILES: C1(O)CNC1.Cl
CAS DataBase Reference: 18621-18-6(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: C,Xi,Xn
Risk Statements: 36/37/38-41-37/38-22
Safety Statements: 26-36/37/39
RIDADR: UN1759
WGK Germany: 3
Hazard Note: Harmful/Corrosive
HazardClass: IRRITANT
HS Code: 29339900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 680079
Product name: 3-Hydroxyazetidine hydrochloride
Purity: 97%
Packaging: 1g
Price: $53.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 680079
Product name: 3-Hydroxyazetidine hydrochloride
Purity: 97%
Packaging: 5g
Price: $117.6
Updated: 2024/03/01

TCI Chemical

Product number: H1264
Product name: 3-Hydroxyazetidine Hydrochloride
Purity: >98.0%(N)
Packaging: 1g
Price: $46
Updated: 2024/03/01

TCI Chemical

Product number: H1264
Product name: 3-Hydroxyazetidine Hydrochloride
Purity: >98.0%(N)
Packaging: 5g
Price: $137
Updated: 2024/03/01

Alfa Aesar

Product number: H25842
Product name: 3-Hydroxyazetidine hydrochloride, 97%
Packaging: 1g
Price: $84.65
Updated: 2024/03/01

More

Less

3-Hydroxyazetidine hydrochloride Chemical Properties,Usage,Production

Description

3-hydroxyazaecyclobutane hydrochloride is an azaecyclobutane compound that is an important intermediate in the synthesis of Brectinib, which is obtained through a multi-step reaction. Brectinib was approved by the European Union. The monotherapy or in combination with methotrexate for the treatment of adult patients with moderate to severe active rheumatoid arthritis with inadequate or intolerant relief from one or more antirheumatic drugs. It is also the first JAK inhibitor approved in the European Union for the treatment of rheumatoid arthritis.

Chemical Properties

white crystal

Uses

3-Hydroxyazetidine hydrochloride is an building block used in a recent synthesis of a fluoroquinolone antibiotic and a useful intermediate in the synthesis of polypeptides.

Synthesis

A solution of l-(diphenylmethyl)-3-hydroxy azetidine hydrochloride (11.8 g) in absolute ethanol (700 mL) was hydrogenated at room temperature over Pd(OH)2/C in a Parr shaker (4 atm). After 12 hr the catalyst was filtered off and the filtrate evaporated to dryness to give3-hydroxyazetidine hydrochloride (4.20 g, 94%).

3-Hydroxyazetidine hydrochloride Preparation Products And Raw materials

Raw materials

Ethanol Palladium Ethyl acetate Benzhydrylamine Hydrochloric acid Methanol Epichlorohydrin Isopropyl alcohol Sodium carbonate

Preparation Products

1-N-Boc-3-hydroxyazetidine 1-Boc-3-(Amino)azetidine

More

Less

3-Hydroxyazetidine hydrochloride Suppliers

Americas 1 Austria 1 Canada 1 China 410 Europe 2 France 1 Germany 7 India 23 Italy 1 Japan 2 Russia 1 Switzerland 1 United Kingdom 17 United States 55 Global 523

Cenik Chemicals

Tel: --
Fax: --
Email: lo@cenikchemicals.com
Country: United Kingdom
ProdList: 1681
Advantage: 58

Melrob Ltd (part of Nordmann)

Tel: --
Fax: --
Email: nquiries@melrob.com
Country: United Kingdom
ProdList: 3065
Advantage: 58

CMS Chemicals Limited

Tel: --
Fax: --
Email: cms.marketing@cms-chemicals.com
Country: United Kingdom
ProdList: 3708
Advantage: 60

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

Carbosynth Limited

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6581
Advantage: 61

Leancare Ltd.

Tel: --
Fax: --
Email: enquiry@leancare.co.uk
Country: United Kingdom
ProdList: 6446
Advantage: 42

Hawks Scientific Ltd

Tel: --
Fax: --
Email: pete@hawks-scientific.com
Country: United Kingdom
ProdList: 2221
Advantage: 43

MOLEKULA Ltd.

Tel: --
Fax: --
Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
Advantage: 66

CARBONE SCIENTIFIC CO.,LTD

Tel: --
Fax: --
Email: sales@carbonesci.com
Country: United Kingdom
ProdList: 6666
Advantage: 30

Manchester Organics

Tel: --
Fax: --
Email: info@manchesterorganics.com
Country: United Kingdom
ProdList: 6834
Advantage: 67

ETA SCIENTIFIC Co.,Ltd

Tel: --
Fax: --
Email: sales@etascientific.com
Country: United Kingdom
ProdList: 6090
Advantage: 34

UK GREEN SCIENTIFIC CO.,LIMITED

Tel: --
Fax: --
Email: sales@gs-chem.com
Country: United Kingdom
ProdList: 6098
Advantage: 47

Fluorochem Ltd

Tel: --
Fax: --
Email: vernam@fluorochem.co.uk
Country: United Kingdom
ProdList: 6375
Advantage: 65

Eurolabs Limited

Tel: --
Fax: --
Country: United Kingdom
ProdList: 6309
Advantage: 46

Fulcrum Scientific Ltd.

Tel: --
Fax: --
Country: United Kingdom
ProdList: 6565
Advantage: 38

Butt Park Ltd.

Tel: --
Fax: --
Email: 113707.50@compuserve.com
Country: United Kingdom
ProdList: 6078
Advantage: 30

Fluorochem Ltd.

Tel: --
Fax: --
Email: enquiries@fluorochem.co.uk
Country: United Kingdom
ProdList: 6401
Advantage: 74

More

Less

View Lastest Price from 3-Hydroxyazetidine hydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 3-Hydroxyazetidine hydrochloride 18621-18-6
Price: US $200.00-95.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-22

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3-Hydroxyazetidine hydrochloride 18621-18-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-02

Hebei Yanxi Chemical Co., Ltd.

Product: 3-Hydroxyazetidine hydrochloride 18621-18-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-08

18621-18-6, 3-Hydroxyazetidine hydrochlorideRelated Search:

1-Chloro-2-methylpropane ISOBUTANE 4-Hydroxyaniline hydrochloride n-Butane Azetidine TRIMETHYLENE OXIDE Azetidine hydrochloride Topotecan hydrochloride Methyl 52,2-difluoroethoxy)-3methyl-2-pyrazinecarboxylate Papain Mosapride citrate 1-(DIPHENYLMETHYL)-3-HYDROXYAZETIDINE HYDROCHLORIDE 3-AZETIDINOL 3-Methoxyazetidine hydrochloride 3-PROPOXY-AZETIDINE HYDROCHLORIDE 1-(Diphenylmethyl)-3-methyl-3-azetidinol hydrochloride 3-ETHOXY-AZETIDINE HYDROCHLORIDE 3-ISOPROPOXY-AZETIDINE HYDROCHLORIDE

3-AZETIDINOL HYDROCHLORIDE

3-HYDROXYAZETIDINE HCL

3-HYDROXYAZETIDINE HYDROCHLORIDE

BUTTPARK 75\04-67

AZETIDIN-3-OL HYDROCHLORIDE

AZETIDIN-3-OL, HYDROCHLORIDE SALT

3-hydroxyazacyclobutane hydrochloride

AZETAN-2-ONE

3-hydroxyazatidine HCl

3-Hydroxyazetidine hydroc...

Azetidin-3-ol hydrochloride, 3-Hydroxyazetane hydrochloride

3-hydroxy-1-azetidine hydrochloride

3-Hydroxyazetidine Hydrochloride, 95+%

3 - hydroxy nitrogen heterocyclic butadiene hydrochloride

3-Azetidinol, hydrochloride (1:1)

-Hydroxyazetidine hydrochloride

3-Hydroxyazetidine Hcl Salt

3-HydroxyazetidineHydrochloride&gt

3-Hydroxyazetidine HydrochL

Baricitinib-009-HCl

Azetidine-3-ol.Hcl

3-Hydroxyl-azetidine HCl

Baricitinib Impurity 11 HCl

Baricitinib Impurity 2 HCl

18621-18-6

8621-18-6

C3H7ClNO

C3H8NOCl

C3H7NOHCl

C3H7NOClH

Azetidines

Amino Acids & Derivatives

Heterocyclic Building Blocks

N-Containing

Others

B-Amino

Amino Acids 13C, 2H, 15N

pharmacetical

Azetidine

Alcohols and Derivatives

Heterocycles