2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name: 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 170491-63-1
Chemical Name: 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: AKOS 92835;BOC-DL-PRO-AL;Boc-DL-Pro-OL;N-Boc-Prolinol;Boc-DL-Prolinol;CAS:170491-63-1;N-Boc-DL-prolinol;1-Boc-2-pyrrolidineMethanol;N-Boc-2-pyrrolidineMethanol;(±)-1-Boc-pyrrolidine-2-Methanol
CBNumber: CB0476463
Molecular Formula: C10H19NO3
Formula Weight: 201.26
MOL File: 170491-63-1.mol

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2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Melting point:: 52-54℃
Boiling point:: 290℃
Density: 1.084
Flash point:: 129℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Methanol
form: powder to crystal
pka: 14.77±0.10(Predicted)
color: White to Almost white
InChIKey: BFFLLBPMZCIGRM-UHFFFAOYSA-N
CAS DataBase Reference: 170491-63-1

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-37
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3273
Product name: N-(tert-Butoxycarbonyl)-DL-prolinol
Purity: >98.0%(GC)
Packaging: 1g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: B3273
Product name: N-(tert-Butoxycarbonyl)-DL-prolinol
Purity: >98.0%(GC)
Packaging: 5g
Price: $86
Updated: 2025/07/31

TRC

Product number: B689485
Product name: N-(tert-Butoxycarbonyl)pyrrolidine-2-methanol
Packaging: 25g
Price: $745
Updated: 2021/12/16

AK Scientific

Product number: W3719
Product name: 1-Boc-(2-Hydroxymethyl)pyrrolidine
Packaging: 1g
Price: $26
Updated: 2021/12/16

Chem-Impex

Product number: 43814
Product name: N-(tert-Butoxycarbonyl)-DL-prolinol,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 1G
Price: $26.58
Updated: 2021/12/16

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2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Uses

N-(tert-Butoxycarbonyl)pyrrolidine-2-methanol is used to prepare 1,3-thiazolidin-2-imines derivatives as inhibitors of nitric oxide synthase.

Synthesis

24424-99-5

498-63-5

170491-63-1

Step 1. Synthesis of tert-butyl 2-hydroxymethylpyrrolidine-1-carboxylate Pyrrolidine-2-methanol (0.300 g, 1.98 mmol) was dissolved in dichloromethane (5.0 mL) and di-tert-butyl dicarbonate (0.650 g, 1.98 mmol) was added. The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the residue was purified by post-processing using Isco Combi-Flash Companion column chromatography (eluent: dichloromethane solution in 0-10% methanol) to afford tert-butyl 2-hydroxymethylpyrrolidine-1-carboxylate (0.590 g, 98% yield). 1H NMR (CDCl3, 300 MHz) δ 4.78 (br d, 1H), 4.05-3.90 (br, 1H), 3.67-3.53 (m, 2H), 3.49-3.41 (m, 1H), 3.34-3.26 (m, 1H), 2.00 (dddd, 1H), 1.85-1.72 (m, 2H). 1.60-1.50 (m, 1H), 1.46 (s, 9H).

References

[1] Patent: US2017/253569, 2017, A1. Location in patent: Paragraph 0994-0995
[2] Tetrahedron, 2005, vol. 61, # 10, p. 2631 - 2643
[3] Patent: US2016/168090, 2016, A1. Location in patent: Paragraph 0823-0824
[4] Patent: WO2011/22508, 2011, A2. Location in patent: Page/Page column 59; 60
[5] Patent: EP2202223, 2010, A1. Location in patent: Page/Page column 72-73

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-Boc-2-pyrrolidinemethanol 170491-63-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

Hebei Yanxi Chemical Co., Ltd.

Product: 1-Boc-2-pyrrolidinemethanol 170491-63-1
Price: US $100.00-2.00/kgkg
Min. Order: 1kgkg
Purity: 99%
Supply Ability: 20tons
Release date: 2023-09-05

Wuhan Monad Medicine Tech Co.,LTD

Product: 1-BOC-(2-HYDROXYMETHYL)PYRROLIDINE 170491-63-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.99%
Supply Ability: 20 tons/month
Release date: 2020-12-24

170491-63-1, 2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

1-N-Boc-2-(hydroxymethyl)piperazine BOC-PRO-OSU BOC-L-Proline BOC-HYP(BZL)-OH N-Boc-cis-4-Hydroxy-L-proline methyl ester N-Boc-D-proline BOC-D-PRO-OME Boc-Hyp-OH BOC-L-Prolinol (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid N-Boc-trans-4-Hydroxy-L-proline methyl ester BOC-OIC-OH BOC-D-PRO-OSU 3(S)-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER,(S)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER,3(R)-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER BOC-HYP-OH DCHA

AKOS 92835

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-N-BOC-2-HYDROXYMETHYLPYRROLIDINE

tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate

(±)-1-Boc-pyrrolidine-2-Methanol

1-Boc-(2-HydroxyMethyl)pyrrolidine

N-(tert-Butoxycarbonyl)pyrrolidine-2-methanol

N-Boc-2-pyrrolidineMethanol

(S)-2-(hydroxyMethyl)-1-pyrrolidinecarboxylic acid,1,1-diMethylethyl ester

N-(tert-Butoxycarbonyl)-DL-prolinol

1-Boc-2-pyrrolidineMethanol

Boc-DL-Prolinol

1-Boc-(2-HydroxyMethyl)pyrrolidine/Boc-DL-Pro-ol

(^+)-1-Boc-pyrrolidine-2-methanol,98%

1-N-Boc-pyrrolidin-2-yl-methanol

N-Boc-Prolinol

BOC-DL-PRO-AL

1-Pyrrolidinecarboxylicacid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester

Boc-DL-Pro-OL

(^+)-1-Boc-pyrrolidine-2-methanol, 98% white powder

N-(tert-Butoxycarbonyl)-DL-prolinol &gt

1-(tert-Butoxycarbonyl)-2-pyrrolidinemethanol

N-Boc-DL-prolinol

2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER USP/EP/BP

CAS:170491-63-1

170491-63-1

17049-63-1

pharmacetical