ChemicalBook > CAS DataBase List > 5-Fluoro-2-methylbenzoic acid
5-Fluoro-2-methylbenzoic acid
- Product Name
- 5-Fluoro-2-methylbenzoic acid
- CAS No.
- 33184-16-6
- Chemical Name
- 5-Fluoro-2-methylbenzoic acid
- Synonyms
- 5-fluoro-2-met;RARECHEM AL BO 0443;5-FLUORO-O-TOLUIC ACID;5-Fluoro-2-methylbenzoic;JVBLXLBINTYFPR-UHFFFAOYSA-N;2-METHYL-5-FLUOROBENZOIC ACID;5-FLUORO-2-METHYLBENZOIC ACID;5-Fluoro-2-methylbenzoicacid99%;5-Fluoro-2-methylbenzoicAcid>Benzoic acid, 5-fluoro-2-Methyl-
- CBNumber
- CB0753120
- Molecular Formula
- C8H7FO2
- Formula Weight
- 154.14
- MOL File
- 33184-16-6.mol
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5-Fluoro-2-methylbenzoic acid Property
- Melting point:
- 130-132 °C (lit.)
- Boiling point:
- 262.1±20.0 °C(Predicted)
- Density
- 1.258±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- pka
- 3.53±0.25(Predicted)
- form
- Crystalline Powder
- color
- Beige to light gray
- BRN
- 2249813
- InChI
- InChI=1S/C8H7FO2/c1-5-2-3-6(9)4-7(5)8(10)11/h2-4H,1H3,(H,10,11)
- InChIKey
- JVBLXLBINTYFPR-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(F)=CC=C1C
- CAS DataBase Reference
- 33184-16-6(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 366625
- Product name
- 5-Fluoro-2-methylbenzoic acid
- Purity
- 99%
- Packaging
- 1g
- Price
- $33.3
- Updated
- 2023/06/20
TCI Chemical
- Product number
- F0844
- Product name
- 5-Fluoro-2-methylbenzoic Acid
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $44
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0844
- Product name
- 5-Fluoro-2-methylbenzoic Acid
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $176
- Updated
- 2025/07/31
TRC
- Product number
- F595260
- Product name
- 5-Fluoro-2-methylbenzoic acid
- Packaging
- 50g
- Price
- $1230
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0024056
- Product name
- 5-FLUORO-2-METHYLBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 100G
- Price
- $2639.18
- Updated
- 2021/12/16
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5-Fluoro-2-methylbenzoic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
5-Fluoro-2-methylbenzoic acid may be used in the preparation of:
- 5-fluoro-3-hydroxy-2-methylbenzoic acid
- 5-fluoro-2-methyl-3-nitrobenzoic acid methyl ester
- 5-fluoro-N,2-dimethylbenzamide
Uses
5-Fluoro-2-methylbenzoic acid is used in preparation of novel iminothiazole derivatives as cannabinoid receptor ligands.
Synthesis
124-38-9
33184-16-6
General procedure for the synthesis of 2-methyl-5-fluorobenzoic acid from carbon dioxide: Commercially available 2-bromo-4-fluorotoluene (5 g) was dissolved in ether (appropriate amount). About 1/3 of this solution was taken and magnesium shavings (761 mg) were added and covered with ether (25 ml). Once the reaction was initiated, the remaining 2-bromo-4-fluorotoluene solution was added slowly and dropwise. The reaction mixture was kept at reflux for 2 hours. The resulting Grignard reagent was poured into a mixture of ether (750 ml) containing crushed dry ice. The reaction mixture was allowed to warm up gradually to room temperature. Subsequently, the solvent was removed by evaporation and the resulting residue was dissolved in ethyl acetate (100 ml) and extracted with 1N aqueous hydrochloric acid (100 ml). The organic phase was dried with magnesium sulfate, filtered and concentrated to give 2-methyl-5-fluorobenzoic acid (2.3 g; 56% yield).1H-NMR (CDCl3) δ: 2.5 (s, 3H), 7.0-7.2 (m, 2H), 7.7 (m, 1H).
References
[1] Patent: WO2006/116157, 2006, A2. Location in patent: Page/Page column 83
5-Fluoro-2-methylbenzoic acid Preparation Products And Raw materials
Raw materials
2-Bromo-4-fluorotoluene
N,N-Dimethylformamide
Sodium chloride
Sodium perborate
Tetrahydrofuran
Ethyl acetate
Acetic acid
Magnesium sulfate
n-Butyllithium
Preparation Products
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View Lastest Price from 5-Fluoro-2-methylbenzoic acid manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 5-Fluoro-2-methylbenzoic acid 33184-16-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 5-Fluoro-2-methylbenzoic acid 33184-16-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
Career Henan Chemical Co
- Product
- 5-Fluoro-2-methylbenzoic acid 33184-16-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-19
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