2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID

Product Name: 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID
CAS No.: 302964-02-9
Chemical Name: 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID
Synonyms: 2-Boc-aminothiazole-5-carboxylic acid;2-N-Boc-Amino-thiazole-5-carboxylic acid, CAS 302964-02-9;2-Amino-1,3-thiazole-5-carboxylic acid, N-BOC protected 97%;2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic Acid;2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic acid;2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic aci...;5-Thiazolecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-;2-N-Boc-AMino-thiazole-5-carboxylicacid/2-(tert-butoxycarbonylaMino)thiazole-5-carboxylicacid
CBNumber: CB11119481
Molecular Formula: C9H12N2O4S
Formula Weight: 244.27
MOL File: 302964-02-9.mol

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2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID Property

Melting point:: 220-222°(dec)
Density: 1.406±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: powder to crystal
pka: 5.53±0.70(Predicted)
color: White to Almost white
CAS DataBase Reference: 302964-02-9

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Safety

Hazard Codes: Xi
Risk Statements: 43-36/37/38
Safety Statements: 36/37-36-26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H317May cause an allergic skin reaction
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00310
Product name: 2-(N-BOC)-Aminothiazole-5-carboxylic acid
Packaging: 1g
Price: $185
Updated: 2025/07/31

TCI Chemical

Product number: B4552
Product name: 2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $463
Updated: 2025/07/31

TCI Chemical

Product number: B4552
Product name: 2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 200mg
Price: $154
Updated: 2025/07/31

TRC

Product number: B693690
Product name: 2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic Acid
Packaging: 1g
Price: $125
Updated: 2021/12/16

AK Scientific

Product number: B303
Product name: 2-(N-BOC)-Aminothiazole-5-carboxylic acid
Packaging: 1g
Price: $41
Updated: 2021/12/16

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2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

A reactant used in the preparation of 2-aminocarboxamidothiazoles as inhibitors of Src-family kinase.

Synthesis

302964-01-8

302964-02-9

General procedure for the synthesis of 2-(tert-butoxycarbonylamino)thiazole-5-carboxylic acid from ethyl 2-(tert-butoxycarbonylamino)thiazole-5-carboxylate: To a vigorously stirred suspension of ethyl 2-(tert-butoxycarbonylamino)thiazole-5-carboxylate (4.2 g, 15 mmol) in methanol (11 mL) was slowly added an aqueous 2 M NaOH solution (22 mL, 44.0 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was concentrated under vacuum by rotary evaporator to remove methanol. The pH was adjusted to 1-2 by adding aqueous 6 N HCl dropwise to the residual aqueous suspension. the mixture was stirred for 1 h, during which time it was occasionally sonicated to promote precipitation. The resulting white solid was collected by filtration, washed thoroughly with deionized water and dried in a vacuum drying oven to afford 2-(tert-butoxycarbonylamino)thiazole-5-carboxylic acid (3.7 g, 100% yield). Mass spectrometry analysis showed (M + H-Boc)+ = 145.

References

[1] Patent: WO2009/100171, 2009, A1. Location in patent: Page/Page column 109
[2] Patent: CN106674150, 2017, A. Location in patent: Paragraph 0022-0026
[3] Patent: US2004/54186, 2004, A1. Location in patent: Page 23
[4] Synthetic Communications, 2017, vol. 47, # 17, p. 1610 - 1621
[5] Asian Journal of Chemistry, 2018, vol. 30, # 7, p. 1621 - 1628

2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID Suppliers

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View Lastest Price from 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID 302964-02-9
Price: US $150.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2018-07-30

302964-02-9, 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID Related Search:

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2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic acid

2-Boc-aminothiazole-5-carboxylic acid

2-N-Boc-AMino-thiazole-5-carboxylicacid/2-(tert-butoxycarbonylaMino)thiazole-5-carboxylicacid

5-Thiazolecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-

2-(<i>tert</i>-Butoxycarbonylamino)thiazole-5-carboxylic Acid

2-Amino-1,3-thiazole-5-carboxylic acid, N-BOC protected 97%

2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic aci...

2-N-Boc-Amino-thiazole-5-carboxylic acid, CAS 302964-02-9

302964-02-9

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