agrimol B

Product Name: agrimol B
CAS No.: 55576-66-4
Chemical Name: agrimol B
Synonyms: agrimol B;AGRIMOL B(P);(S)-(+)-Agrimol B;Agrimol B (-)-Agrimol B;Agrimol B, 10 mM in DMSO;1-Butanone, 1-(3,5-bis((2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl)methyl)-2,4,6-trihydroxyphe;(2S)-1-[3,5-Bis[[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-2,4,6-trihydroxyphenyl]-2-methyl-1-butanone;1-Butanone,1-[3,5-bis[[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-2,4,6-trihydroxyphenyl]-2-methyl-,(2S)-;1-Butanone, 1-(3,5-bis((2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl)methyl)-2,4,6-trihydroxyphenyl)-2-methyl-, (S)-;(S)-1,1'-(((2,4,6-Trihydroxy-5-(2-methylbutanoyl)-1,3-phenylene)bis(methylene))bis(2,4-dihydroxy-6-methoxy-5-methyl-3,1-phenylene))bis(butan-1-one)
CBNumber: CB11354390
Molecular Formula: C37H46O12
Formula Weight: 682.75
MOL File: 55576-66-4.mol

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agrimol B Property

Boiling point:: 922.6±65.0 °C(Predicted)
Density: 1.292
storage temp.: 2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 7.09±0.50(Predicted)
color: White to yellow
InChIKey: BVLHMPZMQVWDGX-INIZCTEOSA-N
SMILES: C(C1=C(O)C(CC2=C(O)C(C(=O)CCC)=C(OC)C(C)=C2O)=C(O)C(CC2=C(O)C(C(=O)CCC)=C(OC)C(C)=C2O)=C1O)(=O)[C@@H](C)CC

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FA73989
Product name: Agrimol B
Packaging: 5mg
Price: $148
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA73989
Product name: Agrimol B
Packaging: 10mg
Price: $236.8
Updated: 2021/12/16

ApexBio Technology

Product number: N2476
Product name: AgrimolB
Packaging: 10mg
Price: $400
Updated: 2021/12/16

ChemScene

Product number: CS-0009720
Product name: AgrimolB
Purity: 99.72%
Packaging: 5mg
Price: $403
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA73989
Product name: Agrimol B
Packaging: 25mg
Price: $473.5
Updated: 2021/12/16

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agrimol B Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, easily soluble in methanol and ethyl acetate, almost insoluble in water, derived from Agrimony.

Uses

Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27[1][2][3].

Biological Activity

Agrimol B, a polyphenol derivative isolated from Agrimony, inhibits adipogenesis, induces the translocation and expression of SIRT1, and reduces the expression of PPARγ.

in vivo

Agrimol B (10 mg/kg, Orally, daily) reduces growth of prostate cancer cell xenograft in mice^[2].

Animal Model:	BALB/c nude mice (6-week-old, male, injected with PC-3 cells in 0.2 mL PBS subcutaneously)^[2]
Dosage:	10 mg/kg
Administration:	Orally, daily, after 15 days of cancer cell implantation
Result:	Inhibited tumor growth in a mouse model of human prostate cancer, reduced the tumor volume at day 31 and day 32.

target

PPAR | Antifection

IC 50

SIRT1; PPARγ

References

[1] Agrimol B, et al. Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway. Biochem Biophys Res Commun. 2016 Aug 26;477(3):454-60. DOI:10.1016/j.bbrc.2016.06.078
[2] Hnit SST, et al. Agrimol B present in Agrimonia pilosa Ledeb impedes cell cycle progression of cancer cells through G0 state arrest. Biomed Pharmacother. 2021 Sep;141:111795. DOI:10.1016/j.biopha.2021.111795
[3] Chun S B, et al. Antibacterial Activities against Plant Pathogens and Identification of Agrimol B from Agrimonia pilosa LEDEB[J]. ?????? ?10? 3?, 2006, 10(3):230-236.

agrimol B Preparation Products And Raw materials

Raw materials

Preparation Products

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agrimol B Suppliers

China 160 India 1 United Kingdom 1 United States 11 Global 173

cjbscvictory

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Sichuan Kulinan Technology Co., Ltd

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Shenzhen Sungening Bio-Tech Co., Ltd

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Chengdu Biopurify Phytochemicals Ltd.

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Beijing HuaMeiHuLiBiological Chemical

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Shanghai Ruji Biology Technology Co., Ltd.

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AdooQ BioScience, LLC

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TargetMol Chemicals Inc.

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View Lastest Price from agrimol B manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Agrimol B 55576-66-4
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-02-26

Career Henan Chemical Co

Product: agrimol B 55576-66-4
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

55576-66-4, agrimol BRelated Search:

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agrimol B

(2S)-1-[3,5-Bis[[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-2,4,6-trihydroxyphenyl]-2-methyl-1-butanone

(S)-(+)-Agrimol B

AGRIMOL B(P)

1-Butanone, 1-(3,5-bis((2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl)methyl)-2,4,6-trihydroxyphenyl)-2-methyl-, (S)-

1-Butanone,1-[3,5-bis[[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-2,4,6-trihydroxyphenyl]-2-methyl-,(2S)-

Agrimol B (-)-Agrimol B

1-Butanone, 1-(3,5-bis((2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl)methyl)-2,4,6-trihydroxyphe

(S)-1,1'-(((2,4,6-Trihydroxy-5-(2-methylbutanoyl)-1,3-phenylene)bis(methylene))bis(2,4-dihydroxy-6-methoxy-5-methyl-3,1-phenylene))bis(butan-1-one)

Agrimol B, 10 mM in DMSO

(S)-1,1'-(((2,4,6-Trihydroxy-5-(2-methylbutanoyl)-1,3-phenylene)bis(methylene))bis(2,4-dihydroxy-6-methoxy-5-methyl-3,1-phenylene))bis(butan-1-one)

55576-66-4

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract