4-Methylmorpholine

Product Name: 4-Methylmorpholine
CAS No.: 109-02-4
Chemical Name: 4-Methylmorpholine
Synonyms: NMM;N-METHYLMORPHOLINE;Methylmorpholine;N-Methyl morphofine;1-Methylmorpholine;Morpholine,4-methyl-;AKOS 89985;Texacat NMM;Lupragen N105;N-Methylmorphol
CBNumber: CB1170931
Molecular Formula: C5H11NO
Formula Weight: 101.15
MOL File: 109-02-4.mol

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4-Methylmorpholine Property

Melting point:: −66 °C(lit.)
Boiling point:: 115-116 °C750 mm Hg(lit.)
Density: 0.92 g/mL at 25 °C(lit.)
vapor density: >1 (vs air)
vapor pressure: 18 mm Hg ( 20 °C)
refractive index: n20/D 1.435(lit.)
Flash point:: 75 °F
storage temp.: Store below +30°C.
solubility: Chloroform (Soluble), Ethyl Acetate, Methanol (Slightly)
form: Liquid
pka: 7.38(at 25℃)
color: Clear
Specific Gravity: 0.920 (20/4℃)
PH: 10.6 (50g/l, H2O, 20℃)
explosive limit: 2.1%(V)
Water Solubility: >500 g/L (20 ºC)
Merck: 14,6277
BRN: 102719
Stability:: Volatile
InChIKey: SJRJJKPEHAURKC-UHFFFAOYSA-N
LogP: -0.32 at 25℃
CAS DataBase Reference: 109-02-4(CAS DataBase Reference)
NIST Chemistry Reference: Morpholine, 4-methyl-(109-02-4)
EPA Substance Registry System: 4-Methylmorpholine (109-02-4)

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Safety

Hazard Codes: F,C
Risk Statements: 11-20/21/22-34-10-22
Safety Statements: 16-26-36/37/39-45-25
RIDADR: UN 2535 3/PG 2
WGK Germany: 1
RTECS: QE5775000
F: 10-23
Autoignition Temperature: 165 °C DIN 51794
TSCA: Yes
HazardClass: 3
PackingGroup: II
HS Code: 29349990
Toxicity: LD50 orally in Rabbit: 1960 mg/kg LD50 dermal Rabbit 1240 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.05894
Product name: 4-Methylmorpholine
Purity: for synthesis
Packaging: 5ml
Price: $25.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.05894
Product name: 4-Methylmorpholine
Purity: for synthesis
Packaging: 250ML
Price: $33.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.05894
Product name: 4-Methylmorpholine
Purity: for synthesis
Packaging: 1L
Price: $129
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.05894
Product name: 4-Methylmorpholine
Purity: for synthesis
Packaging: 2.5L
Price: $240
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.05894
Product name: 4-Methylmorpholine
Purity: for synthesis
Packaging: 25kg
Price: $913
Updated: 2024/03/01

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4-Methylmorpholine Chemical Properties,Usage,Production

Chemical Properties

colorless and transparent liquid. with characteristic odor. soluble in organic solvents, miscible with water and ethanol.

Uses

4-Methylmorpholine is an excellent solvent, emulsifier, corrosion inhibitor, Catalyst in polyurethane foamsextraction solvent, stabilizing agent for chlorinated hydrocarbons, and also can be used as pesticide intermediates. 4-Methylmorpholine is widely used in the synthesis of pesticide compounds such as insecticide, fungicide, plant growth regulator, etc. It is also used in the synthesis of fine chemicals such as surfactant, lubricant coolant, metal antirust agent, fiber treatment agent, etc.

Preparation

4-Methylmorpholine preparation method is to slowly add formaldehyde in morpholine drop by drop, under stirring add formic acid reaction, automatic reflux, and release carbon dioxide. After adding formic acid, heating reflux 4 ~ 5h, cooling and adding sodium hydroxide immediately distillation, collect all the fraction before the boiling point of 99 ℃, and then add sodium hydroxide in the fraction to saturation, cooling the oil layer, drying, fractional distillation, to obtain N-methylmorpholine.

Synthesis Reference(s)

Tetrahedron Letters, 36, p. 4881, 1995 DOI: 10.1016/0040-4039(95)00875-D

General Description

4-Methylmorpholine is a water-white liquid with an ammonia-like odor. Less dense than water and insoluble in water. Flash point 75°F. May be moderately toxic by ingestion, inhalation and skin absorption. Very irritating to skin, eyes, and mucous membranes. Used as a solvent and to make pharmaceuticals.

Air & Water Reactions

Highly flammable. Insoluble in water.

Reactivity Profile

Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Flammable

Purification Methods

Dry it by refluxing with BaO or sodium, then fractionally distil it through a helices-packed column. The picrate has m 227o, the thiocyanate salt has m 103o (from butanone). [Hall J Phys Chem 60 63 1956, Beilstein 27 I 203, 27 III/IV 22.]

4-Methylmorpholine Preparation Products And Raw materials

Raw materials

Diethylene glycol Methylamine Formaldehyde Formic acid 2,2'-Dichlorodiethyl ether Morpholine Glyoxylic acid Ammonia

Preparation Products

Tenidap Fosinopril Cefpiramide acid Benazepril 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl morpholinium chloride Azasetron hydrochloride 3-Amino-5-fluoropyridine 1-Boc-4-(aminomethyl)piperidine 3-Aminomethyl-1-N-Boc-piperidine 4-Methylmorpholine N-oxide monohydrate Zafirlukast 1-Hydroxybenzotriazole hydrate Alacepril

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4-Methylmorpholine Suppliers

Americas 1 Belgium 2 Canada 2 China 369 Europe 4 France 4 Germany 18 India 55 Ireland 1 Italy 1 Japan 10 Malaysia 1 New Zealand 1 Singapore 1 Slovakia 1 South Korea 1 Switzerland 3 Turkey 1 Ukraine 1 United Kingdom 15 United States 55 Global 547

Huntsman Advanced Materials (UK) Ltd.

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Tennants Distribution Limited

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Cenik Chemicals

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Molekula Limited

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Melrob Ltd (part of Nordmann)

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LEHVOSS UK / Gee Lawson Chemical Division

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Manchester Organics

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CARBONE SCIENTIFIC CO.,LTD

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MOLEKULA Ltd.

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Fluorochem Ltd

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Huntsman Tioxide

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VWR International

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Eurolabs Limited

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View Lastest Price from 4-Methylmorpholine manufacturers

Yancheng Green Chemicals Co.,Ltd

Product: 4-Methylmorpholine 109-02-4
Price: US $1.00/kg
Min. Order: 1000kg
Purity: 99
Supply Ability: 10000
Release date: 2022-12-13

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Methylmorpho line 109-02-4
Price: US $9.10/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 10000
Release date: 2024-08-23

Hebei Weibang Biotechnology Co., Ltd

Product: 4-Methylmorpholine 109-02-4
Price: US $25.00/KG
Min. Order: 100ASSAYS
Purity: 99.5%
Supply Ability: 100 mt
Release date: 2021-08-04

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Dapagliflozin Impurity 162

Englenet Impurity 23

Empagliflozin Impurity 65

Dapagliflozin Impurity 52

Cetilistat Impurity 17

Engel net impurity 65

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109-02-4

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CH3NCH2CH2OCH2CH2

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