Ethyl 2-bromobenzoate
- Product Name
- Ethyl 2-bromobenzoate
- CAS No.
- 6091-64-1
- Chemical Name
- Ethyl 2-bromobenzoate
- Synonyms
- RARECHEM AL BI 0014;ETHYL 2-BROMOBENZOATE;Ethyl 2-Bromobenzoate >Ethyl 2-bromobenzoate, 98+%;2-Bromobezoic acid, ethyl ester;2-BROMOBENZOIC ACID ETHYL ESTER;Ethyl 2-broMobenzoate, 98% 25GR;ETHYL 2-BROMOBENZOATE FOR SYNTHESIS
- CBNumber
- CB1183081
- Molecular Formula
- C9H9BrO2
- Formula Weight
- 229.07
- MOL File
- 6091-64-1.mol
Ethyl 2-bromobenzoate Property
- Boiling point:
- 117 °C/17 mmHg (lit.)
- Density
- 1.443 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.544(lit.)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Dichloromethane, Ethyl Acetate
- form
- Liquid
- color
- Clear yellow
- BRN
- 2207360
- CAS DataBase Reference
- 6091-64-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethyl 2-bromobenzoate(6091-64-1)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 335800
- Product name
- Ethyl 2-bromobenzoate
- Purity
- 98%
- Packaging
- 25g
- Price
- $96.5
- Updated
- 2023/01/07
- Product number
- B1514
- Product name
- Ethyl 2-Bromobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- 448876
- Product name
- Ethyl 2-Bromobenzoate
- Packaging
- 10g
- Price
- $312
- Updated
- 2021/12/16
- Product number
- JK206637
- Product name
- Ethyl 2-bromobenzoate
- Purity
- 98%
- Packaging
- 100g
- Price
- $213
- Updated
- 2021/12/16
- Product number
- 2623-9-15
- Product name
- Ethyl 2-bromobenzoate
- Packaging
- 25g
- Price
- $31
- Updated
- 2021/12/16
Ethyl 2-bromobenzoate Chemical Properties,Usage,Production
Chemical Properties
clear yellow liquid
Uses
Ethyl 2-bromobenzoate is an intermediate of 7H-Benzo[c]fluorene, which is a polycyclic aomatic hydrocarbon (PAH) with mutagenic activity. 7H-Benzo[c]fluorene is a major DNA adduct-forming component of coal tar. Recent studies suggest that 7H-Benzo[c]fluorene may be capable of inducing lung tumors.
General Description
Ethyl 2-bromobenzoate is an halobenzoic acid ethyl ester. Silylation and hydrolysis of ethyl 2-bromobenzoate has been reported.
Synthesis
64-17-5
88-65-3
6091-64-1
O-bromobenzoic acid (5 g, 24.87 mmol) was dissolved in anhydrous ethanol (100 mL). Concentrated sulfuric acid (5 mL) was slowly added as a catalyst, a reflux condensing unit was installed, and the system was heated to reflux temperature in an oil bath with continuous stirring for 24 hours. After the reaction was completed, the reaction system was cooled to room temperature. Most of the ethanol solvent was removed by concentration under reduced pressure by rotary evaporator. The residue was transferred to a partition funnel, washed with deionized water to remove acidic impurities, and subsequently extracted with ethyl acetate (3 x 50 mL). The organic phases were combined and dried with anhydrous magnesium sulfate for 30 min. The desiccant was removed by filtration and the filtrate was concentrated by rotary evaporation to obtain the crude product. Finally, the crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=10:1) to afford ethyl 2-bromobenzoate (4.9 g, 86% yield) as a colorless oily liquid.
References
[1] Journal of Organic Chemistry, 2007, vol. 72, # 5, p. 1803 - 1806
[2] Patent: CN105555761, 2016, A. Location in patent: Paragraph 0344; 0345; 0346
[3] Patent: US9896467, 2018, B1. Location in patent: Page/Page column 32; 33
[4] Patent: CN108164532, 2018, A. Location in patent: Paragraph 0076; 0078; 0079
[5] Journal of the American Chemical Society, 1944, vol. 66, p. 914,917
Ethyl 2-bromobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 2-bromobenzoate manufacturers
- Product
- Ethyl 2-bromobenzoate 6091-64-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Ethyl 2-bromobenzoate 6091-64-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-02