6-Chloropicolinic acid
- Product Name
- 6-Chloropicolinic acid
- CAS No.
- 4684-94-0
- Chemical Name
- 6-Chloropicolinic acid
- Synonyms
- 6-CPA;2-CHLORO-6-PYRIDINECARBOXYLIC ACID;6-CHLOROPIC;6-Chloro-2-pic;6-chloropicolinic;OTAVA-BB BB5110090024;nitrapyrin metabolite;6-chloro-picolinicaci;Farnesane Impurity 43;6-CHLOROPICOLINIC ACID
- CBNumber
- CB1207534
- Molecular Formula
- C6H4ClNO2
- Formula Weight
- 157.55
- MOL File
- 4684-94-0.mol
6-Chloropicolinic acid Property
- Melting point:
- 190-191°C
- Boiling point:
- 241.15°C (rough estimate)
- Density
- 1.3768 (rough estimate)
- refractive index
- 1.5870 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol
- pka
- 3.27±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to cream to tan
- Water Solubility
- 3.40g/L(temperature not stated)
- λmax
- 294nm(EtOH)(lit.)
- BRN
- 115849
- InChIKey
- ZLKMOIHCHCMSFW-UHFFFAOYSA-N
- CAS DataBase Reference
- 4684-94-0(CAS DataBase Reference)
- EPA Substance Registry System
- 6-Chloropicolinic acid (4684-94-0)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H303May be harmfulif swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H401Toxic to aquatic life
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C1896
- Product name
- 6-Chloro-2-pyridinecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $40
- Updated
- 2025/07/31
- Product number
- C1896
- Product name
- 6-Chloro-2-pyridinecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $120
- Updated
- 2025/07/31
- Product number
- C380615
- Product name
- 6-Chloropyridine-2-carboxylic acid
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- C380615
- Product name
- 6-Chloropyridine-2-carboxylic acid
- Packaging
- 5g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- C380615
- Product name
- 6-Chloropyridine-2-carboxylic acid
- Packaging
- 100g
- Price
- $250
- Updated
- 2021/12/16
6-Chloropicolinic acid Chemical Properties,Usage,Production
Chemical Properties
Off-white Plates
Uses
6-Chloropyridine-2-carboxylic Acid is an intermediate of Sorafenib b(S676850), a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Antineoplastic.
Synthesis
1929-82-4
4684-94-0
General procedure for the synthesis of 6-chloropyridine-2-carboxylic acid from 2-chloro-6-trichloromethylpyridine: 2-chloro-6-trichloromethylpyridine (115.5 g, 0.5 mol) and 98% concentrated sulfuric acid (60 g, 0.6 mol) were added sequentially to a 500 mL three-neck flask equipped with a thermometer. The reaction mixture was heated to 100 °C and maintained at this temperature for 8 hours. Upon completion of the reaction, the reaction solution was cooled to 60 °C and neutralized by slow dropwise addition of 27% ammonia until the pH reached 7. Subsequently, the reaction mixture was cooled to room temperature with continuous stirring to precipitate the solid. The white solid product was collected by diafiltration in 90% yield with a melting point of 192-193 °C.
References
[1] Patent: CN108530351, 2018, A. Location in patent: Paragraph 0011; 0026; 0027
6-Chloropicolinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
6-Chloropicolinic acid Suppliers
- Tel
- --
- Fax
- --
- info@specs.net
- Country
- The Netherlands
- ProdList
- 6833
- Advantage
- 70
View Lastest Price from 6-Chloropicolinic acid manufacturers
- Product
- 6-Chloropicolinic acid 4684-94-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
- Product
- 6-Chloropicolinic acid 4684-94-0
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- 6-Chloropicolinic acid 4684-94-0
- Price
- US $1.00-22.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-08-06