ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE
Application- Product Name
- ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE
- CAS No.
- 43088-42-2
- Chemical Name
- ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE
- Synonyms
- methyl 2-amino-4-methylthiophene-3-carboxylate;BUTTPARK 29\08-49;2-aMino-4-Methylthiophene-3-carboxylate;2-Amino-3-(ethoxycarbonyl)-4-methylthiophene;thyl 2-amino-4-methylthiophene-3-carboxylate;Ethyl 2-amino-4-methyl-3-thiophenecarboxylate;ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE;Eethyl 2-amino-4-methylthiophene-3-carboxylate;2-aMino-5-ethyl-4-Methylthiophene-3-carboxylate;Ethyl 2-Amino-4-methylthiophene-3-carboxylate >
- CBNumber
- CB1241998
- Molecular Formula
- C8H11NO2S
- Formula Weight
- 185.24
- MOL File
- 43088-42-2.mol
ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE Property
- Melting point:
- 80 °C
- Boiling point:
- 279℃
- Density
- 1.219
- Flash point:
- 123℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Water Solubility
- Soluble in water
- form
- powder to crystal
- pka
- 0.24±0.10(Predicted)
- color
- Light yellow to Yellow to Orange
- BRN
- 1366073
- InChI
- InChI=1S/C8H11NO2S/c1-3-11-8(10)6-5(2)4-12-7(6)9/h4H,3,9H2,1-2H3
- InChIKey
- ILYCZKOBLRJJSW-UHFFFAOYSA-N
- SMILES
- C1(N)SC=C(C)C=1C(OCC)=O
- CAS DataBase Reference
- 43088-42-2(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- HazardClass
- IRRITANT
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E1103
- Product name
- Ethyl 2-Amino-4-methylthiophene-3-carboxylate
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- E1103
- Product name
- Ethyl 2-Amino-4-methylthiophene-3-carboxylate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $150
- Updated
- 2025/07/31
- Product number
- E899578
- Product name
- Ethyl 2-Amino-4-methylthiophene-3-carboxylate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 062874
- Product name
- Ethyl 2-amino-4-methylthiophene-3-carboxylate
- Packaging
- 5g
- Price
- $78
- Updated
- 2021/12/16
- Product number
- X0323
- Product name
- Ethyl 2-Amino-4-methylthiophene-3-carboxylate
- Packaging
- 10g
- Price
- $86
- Updated
- 2021/12/16
ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE Chemical Properties,Usage,Production
Application
2-Amino-4-methyl-thiophene-3-carboxylic acid ethyl ester is an ester organic compound that can be used as a pharmaceutical intermediate.
Chemical Properties
Yellow solid
Synthesis
105-56-6
67-64-1
43088-42-2
GENERAL METHOD: Cyclohexanone (1.06 mL, 10 mmol), ethyl cyanoacetate (1.15 mL, 10 mmol), morpholine (0.90 mL, 10 mmol), and sulfur powder (0.32 g, 10 mmol) were dissolved in ethanol (10 mL), and the reaction was stirred and refluxed overnight. After completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by distillation under reduced pressure. The resulting crude product was washed with cold ethanol, filtered through a sintered funnel and dried under vacuum. The dried crude product was dissolved in dichloromethane and washed with saturated saline. The organic layer was separated and concentrated under reduced pressure to afford the target compound ethyl 2-amino-4-methylthiophene-3-carboxylate (2a) in 73% yield (1.83 g).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 13, p. 4418 - 4427
[2] European Journal of Medicinal Chemistry, 2014, vol. 86, p. 270 - 278
[3] Patent: CN107151251, 2017, A. Location in patent: Paragraph 0006; 0010
[4] Organic and Biomolecular Chemistry, 2014, vol. 12, # 24, p. 4233 - 4242
[5] Journal of Molecular Catalysis B: Enzymatic, 2013, vol. 95, p. 29 - 35
ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE Suppliers
- Tel
- --
- Fax
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- nfo@matrix-fine-chemicals.com
- Country
- Switzerland
- ProdList
- 6968
- Advantage
- 58
View Lastest Price from ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE manufacturers
- Product
- ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE 43088-42-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE 43088-42-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2019-08-05