ChemicalBook > CAS DataBase List > 4-Chloroanisole

4-Chloroanisole

Product Name
4-Chloroanisole
CAS No.
623-12-1
Chemical Name
4-Chloroanisole
Synonyms
1-CHLORO-4-METHOXYBENZENE;P-CHLOROANISOLE;para-Chloroanisole;4-Methoxyphenyl chloride;p-chloroanisol;4-Chloroanisol;Chloro anisole;4-CHLOROANISOLE;3 4-Chloroanisole;Anisole, p-chloro-
CBNumber
CB1312283
Molecular Formula
C7H7ClO
Formula Weight
142.58
MOL File
623-12-1.mol
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4-Chloroanisole Property

Melting point:
-18 °C (lit.)
Boiling point:
198-202 °C (lit.)
Density 
1.164 g/mL at 25 °C (lit.)
vapor pressure 
1.08hPa at 25℃
refractive index 
n20/D 1.535(lit.)
Flash point:
173 °F
storage temp. 
Sealed in dry,Room Temperature
form 
Liquid
color 
Clear colorless to yellow
Water Solubility 
immiscible
BRN 
1858901
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
LogP
2.78 at 25℃
CAS DataBase Reference
623-12-1(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 1-chloro-4-methoxy-(623-12-1)
EPA Substance Registry System
Benzene, 1-chloro-4-methoxy- (623-12-1)
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Safety

Hazard Codes 
Xn
Safety Statements 
23-24/25
RIDADR 
UN 2810
WGK Germany 
3
TSCA 
Yes
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
159069
Product name
4-Chloroanisole
Purity
99%
Packaging
25g
Price
$102
Updated
2024/03/01
Sigma-Aldrich
Product number
159069
Product name
4-Chloroanisole
Purity
99%
Packaging
100g
Price
$286
Updated
2023/06/20
TCI Chemical
Product number
C0122
Product name
4-Chloroanisole
Purity
>98.0%(GC)
Packaging
25g
Price
$44
Updated
2024/03/01
TCI Chemical
Product number
C0122
Product name
4-Chloroanisole
Purity
>98.0%(GC)
Packaging
500g
Price
$252
Updated
2024/03/01
Alfa Aesar
Product number
A11377
Product name
4-Chloroanisole, 99%
Packaging
50g
Price
$57.65
Updated
2024/03/01
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4-Chloroanisole Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Uses

4-Chloroanisole was found to react with Cu (II)-smectite forming a blue clay-organic complex. 4-Chloroanisole was chosen as the main test substrate for the optimisation studies as it is electronically deactivated and thus resistant to oxidative addition and consequently very reluctant to enter a catalytic manifold.

Synthesis Reference(s)

Chemistry Letters, 16, p. 1901, 1987
The Journal of Organic Chemistry, 35, p. 528, 1970 DOI: 10.1021/jo00827a060

General Description

4-Chloroanisole is an electron-rich chloroarene. It undergoes Ullmann-type homocoupling catalyzed by in situ generated Pd colloids. Reaction of 4-chloroanisole with Cu(II)-smectite in n-hexane, carbon tetrachloride or dichloromethane has been studied. The nucleophilic photosubstitution reactions, photocyanation and photohydrolysis of 4-chloroanisole has been studied by time resolved spectroscopy.

Purification Methods

Wash the anisole with 10% (by volume) aqueous H2SO4 (three times), 10% aqueous KOH (three times), and then with water until neutral. Dry it (MgSO4), and fractionally distil it from CaH2 through a glass helices-packed column under reduced pressure. [Beilstein 16 IV 822.]

4-Chloroanisole Preparation Products And Raw materials

Raw materials

Disulfur dichloride o-Cresol

Preparation Products

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4-Chloroanisole Suppliers

Americas 1 Belgium 2 Canada 1 China 236 Europe 3 Germany 8 India 24 Japan 4 Slovakia 1 South Korea 1 Switzerland 3 United Kingdom 16 United States 31 Global 331
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28398
Advantage
80
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View Lastest Price from 4-Chloroanisole manufacturers

Hebei Duling International Trade Co. LTD
Product
4-Chloroanisole 623-12-1
Price
US $65.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 tons
Release date
2023-04-24
Hebei Mojin Biotechnology Co., Ltd
Product
4-Chloroanisole 623-12-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-07
Hebei Guanlang Biotechnology Co,.LTD
Product
4-Chloroanisole 623-12-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2021-06-28

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